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LCP1 correlates with immune infiltration: a prognostic marker for triple-negative breast cancer
ObjectiveTriple-Negative Breast Cancer (TNBC) is known for its aggressiveness and treatment challenges due to the absence of ER, PR, and HER2...
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Anti-IL-17 Inhibits PINK1/Parkin Autophagy and M1 Macrophage Polarization in Rheumatic Heart Disease
Rheumatic heart disease (RHD) is an important and preventable cause of cardiovascular death and disability, but the lack of clarity about its exact...
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Inhibition of PKC-δ retards kidney fibrosis via inhibiting cGAS-STING signaling pathway in mice
Kidney fibrosis is considered to be the ultimate aggregation pathway of chronic kidney disease (CKD), but its underlying mechanism remains elusive....
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GIS-based spatiotemporal map** of malaria prevalence and exploration of environmental inequalities
Malaria poses a significant threat to global health, with particular severity in Nigeria. Understanding key factors influencing health outcomes is...
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Association of HLA-G 3′UTR polymorphisms with hepatitis B virus infection in Tunisian population
Hepatitis B virus (HBV) infection is a major public health burden. The mechanisms of immune evasion during chronic HBV (CHB) infection are poorly...
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Origin recognition complex 6 overexpression promotes growth of glioma cells
The discovery of novel oncotargets for glioma is of immense significance. We here explored the expression patterns, biological functions, and...
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Yixin-Fumai granules modulate autophagy through the PI3K/AKT/FOXO pathway and lead to amelioration of aging mice with sick sinus syndrome
ObjectiveBy employing network pharmacology alongside molecular docking techniques, we can delve into the intricate workings of Yixin-Fumai granules...
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Demonstration for cold atmospheric pressure plasma jet operation and antibacterial action in microgravity
Cold atmospheric pressure plasma (ionized gas) is an innovative medical tool for the treatment of infected wounds thanks to its potential to...
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Alteration of β-glucan in the emerging fungal pathogen Candida auris leads to immune evasion and increased virulence
Candida auris is an emerging pathogenic yeast that has been categorized as a global public health threat and a critical priority among fungal...
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GSTO1 aggravates EGFR-TKIs resistance and tumor metastasis via deglutathionylation of NPM1 in lung adenocarcinoma
Despite significantly improved clinical outcomes in EGFR-mutant lung adenocarcinoma, all patients develop acquired resistance and malignancy on the...
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Long-term survivals of immune checkpoint inhibitors as neoadjuvant and adjuvant therapy in dMMR/MSI-H colorectal and gastric cancers
BackgroundThe long-term survival benefit of immune checkpoint inhibitors (ICIs) in neoadjuvant and adjuvant settings is unclear for colorectal...
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Role of ferroptosis in radiation-induced soft tissue injury
Ionizing radiation has been pivotal in cancer therapy since its discovery. Despite its therapeutic benefits, IR causes significant acute and chronic...
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A novel LGALS1-depended and immune-associated fatty acid metabolism risk model in acute myeloid leukemia stem cells
Leukemia stem cells (LSCs) are recognized as the root cause of leukemia initiation, relapse, and drug resistance. Lipid species are highly abundant...
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Positive feedback loop of c-myc/XTP6/NDH2/NF-κB to promote malignant progression in glioblastoma
BackgroundRecent studies have highlighted the significant role of the NF-κB signaling pathway in the initiation and progression of cancer....
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lncRNA FGD5-AS1 is required for gastric cancer proliferation by inhibiting cell senescence and ROS production via stabilizing YBX1
BackgroundThe vast majority of lncRNAs have low expression abundance, which greatly limits their functional range and impact. As a high expression...
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Gut-Derived Short-Chain Fatty Acids and Macrophage Modulation: Exploring Therapeutic Potentials in Pulmonary Fungal Infections
Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, modulate immune cell functions, particularly macrophages. This review...
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Phase separation of RNF214 promotes the progression of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, and the expression and function of an uncharacterized protein RNF214 in...
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Elastin-derived peptides (EDPs) as a potential pro-malignancy factor in human leukemia cell lines
AbstractThe extracellular matrix (ECM) is currently considered to be an important factor influencing the migration and progression of cancer cells....