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Human genetics Oncology

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  2. Advanced Targeting Strategies for Murine Retroviral and Adeno-associated Viral Vectors

    Targeted gene delivery involves broadening viral tropism to infect previously nonpermissive cells, replacing viral tropism to infect a target cell...
    Julie H. Yu, David V. Schaffer in Gene Therapy and Gene Delivery Systems
    Chapter

  3. Nonviral Delivery of Cancer Genetic Vaccines

    The potential use of genetic vaccines to address numerous diseases including cancer is promising, but currently unrealized. Here, we review...
    Steven R. Little, Robert Langer in Gene Therapy and Gene Delivery Systems
    Chapter

  4. Production and Formulation of Adenovirus Vectors

    Adenovirus vectors have attracted considerable interest over the past decade, with ongoing clinical development programs for applications ranging...
    Nedim E. Altaras, John G. Aunins, ... Jayanthi J. Wolf in Gene Therapy and Gene Delivery Systems
    Chapter

  5. Molecular Conjugates

    Molecular conjugates are nanometer-sized entities consisting of synthetic materials (lipids, polycations, targeting agents, and so on) and nucleic...
    Jeremy Heidel, Swaroop Mishra, Mark E. Davis in Gene Therapy and Gene Delivery Systems
    Chapter

  6. Lentiviral Vectors

    We review the use of lentiviral vectors in current human gene therapy applications that involve genetic modification of nondividing tissues with...
    Nils Loewen, Eric M. Poeschla in Gene Therapy and Gene Delivery Systems
    Chapter

  7. Plasmid Vaccines and Therapeutics: From Design to Applications

    In the late 1980s, Vical and collaborators discovered that the injection into tissues of unformulated plasmid encoding various proteins resulted in...
    Marston Manthorpe, Peter Hobart, ... Alain Rolland in Gene Therapy and Gene Delivery Systems
    Chapter

  8. Adeno-associated Virus as a Gene Therapy Vector: Vector Development, Production and Clinical Applications

    Adeno-associated virus (AAV) has emerged as an attractive vector for gene therapy. AAV vectors have successfully been utilized to promote...
    Joshua C. Grieger, Richard J. Samulski in Gene Therapy and Gene Delivery Systems
    Chapter

  9. Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition

    SF3B1 mutations frequently occur in cancer yet lack targeted therapies. Clinical trials of XPO1 inhibitors, selinexor and eltanexor, in high-risk...

    Sana Chaudhry, Felipe Beckedorff, ... Justin Taylor in Leukemia
    Article Open access 13 July 2024

  10. Death anxiety among caregivers of patients with advanced cancer: a cross-sectional survey

    Purpose

    This study aimed to investigate death anxiety (DA) in caregivers of patients with advanced cancer and identify associated factors in the...

    Li Ying, Duan Yuyu, ... Zhou Zhihuan in Supportive Care in Cancer
    Article 13 July 2024

  12. Carbon-ion radiotherapy alone vs. standard dose photon radiation with carbon-ion radiotherapy boost for high-grade gliomas: a retrospective study

    Background

    This study aimed to compare the survival outcome and side effects in patients with primary high-grade glioma (HGG) who received carbon ion...

    **aoJun Li, YanShan Zhang, ... Faxin Wen in BMC Cancer
    Article Open access 13 July 2024

  13. Safety and Efficacy of Covered Self-Expandable Metallic Stent for Choledochojejunal Anastomotic Stricture: A Multi-Center Retrospective Cohort Study

    Background

    Benign choledochojejunal anastomotic stricture (CJS) is a complication of pancreaticoduodenectomy and choledochojejunostomy. Typically...

    Yuhei Iwasa, Takuji Iwashita, ... Masahito Shimizu in Digestive Diseases and Sciences
    Article 13 July 2024

  14. Deep learning model based on endoscopic images predicting treatment response in locally advanced rectal cancer undergo neoadjuvant chemoradiotherapy: a multicenter study

    Purpose

    Neoadjuvant chemoradiotherapy has been the standard practice for patients with locally advanced rectal cancer. However, the treatment response...

    Junhao Zhang, Ruiqing Liu, ... Yun Lu in Journal of Cancer Research and Clinical Oncology
    Article Open access 13 July 2024

  15. Psychological and ethical issues raised by genomic in paediatric care pathway, a qualitative analysis with parents and childhood cancer patients

    In paediatric oncology, genomics raises new ethical, legal and psychological issues, as somatic and constitutional situations intersect throughout...

    Marion Droin-Mollard, Sandrine de Montgolfier, ... Khadija Lahlou-Laforêt in European Journal of Human Genetics
    Article Open access 13 July 2024

  16. Peripheral blood immune parameters, response, and adverse events after neoadjuvant chemotherapy plus durvalumab in early-stage triple-negative breast cancer

    Purpose

    We evaluated T- and B-cell receptor (TCR and BCR) repertoire diversity and 38 serum cytokines in pre- and post-treatment peripheral blood of...

    Julia Foldi, Kim R. M. Blenman, ... Lajos Pusztai in Breast Cancer Research and Treatment
    Article 13 July 2024

  17. Association of oral mucositis induced by anthracycline-cyclophosphamide and subsequent docetaxel treatment for perioperative breast cancer

    Purpose

    Anthracycline-cyclophosphamide followed by docetaxel-containing chemotherapy is effective for perioperative breast cancer treatment. However,...

    Yoshitaka Saito, Yoh Takekuma, ... Mitsuru Sugawara in Supportive Care in Cancer
    Article 13 July 2024

  18. Hyponatremia Is Associated with Mortality in Acute Pancreatitis Patients

    Background

    Disorders of serum sodium are common among general patients and are associated with poor outcomes. The prognostic value of serum sodium...

    Liqing Song, Wen Tang, ... Ying Xu in Digestive Diseases and Sciences
    Article 13 July 2024

  20. An update to experimental and clinical aspects of tumor-associated macrophages in cancer development: hopes and pitfalls

    Tumor-associated macrophages (TAMs) represent one of the most abundant tumor-infiltrating stromal cells, and their normal function in tumor...

    Arash Salmaninejad, Sepideh Mehrpour Layeghi, ... Meysam Yousefi in Clinical and Experimental Medicine
    Article Open access 13 July 2024
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