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Endocytosis and Membrane Recycling in Pollen Tubes
In plants, tip-growing cells are an ideal system to investigate signal transduction mechanisms and, among these, pollen tubes are one of the...
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Diazo and Diazonium DNA Cleavage Agents: Studies on Model Systems and Natural Product Mechanisms of Action
Diazonium salts have been previously used to cleave DNA via generation of carbon centered radicals and cations. Efforts have been made in the...
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Marine Polyether Compounds
Due to their chemical complexity and potent biological activity, marine polyether compounds produced by marine unicellular algae are of interest to...
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Bioactive Heterocyclic Alkaloids of Marine Origin
Many kinds of alkaloids with extraordinary structures and significant biological activities have been isolated from marine organisms. This work...
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Predicting Pharmacological and Toxicological Activity of Heterocyclic Compounds Using QSAR and Molecular Modeling
Heterocyclic compounds are important as drugs, toxicants, and agrochemicals. In this review, we report the QSAR modeling of pharmacological...
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Plant Prevacuolar Compartments and Endocytosis
Prevacuolar compartments (PVCs) are membrane-bound organelles mediating protein traffic from both Golgi and plasma membrane to vacuoles in...
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Biological Organometallic Chemistry of B12
Vitamin B12, the “antipernicious anemia factor” required for human and animal metabolism, was discovered in the late 1940s. B12-derivatives are...
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The Roles of Chromatin Remodelling Factors in Replication
Dynamic changes of chromatin structure control DNA-dependent events, including DNA replication. Along with DNA, chromatin organization must be...
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The Generation and Recognition of Histone Methylation
The posttranslational modification of histone proteins via methylation has important functions in gene activation, transcriptional silencing,...
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Structure and Function of Protein Modules in Chromatin Biology
Chromatin-mediated gene transcription or silencing is a dynamic process in which binding of various proteins or protein complexes can displace...
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Histone Dynamics During Transcription: Exchange of H2A/H2B Dimers and H3/H4 Tetramers During Pol II Elongation
Chromatin within eukaryotic cell nuclei accommodates many complex activities that require at least partial disassembly and reassembly of...
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Mouse Models of Cell Cycle Regulators: New Paradigms
In yeast, a single cyclin-dependent kinase (Cdk) is able to regulate diverse cell cycle transitions (S and M phases) by associating with multiple...
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Folding of newly synthesised proteins in the endoplasmic reticulum
The endoplasmic reticulum (ER) is a membranous compartment that can be found within any nucleated eukaryotic cell. Its job is to oversee the...
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Structural features of fungal genomes
Eighteen fungal genomes have been sequenced to date from a variety of taxonomic groups, with fifteen Ascomycota, two Basidomycota and one...
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Histone Ubiquitylation and the Regulation of Transcription
The small (76 amino acids) and highly conserved ubiquitin protein plays key roles in the physiology of eukaryotic cells. Protein ubiquitylation...
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Medicinal Properties of Organometallic Compounds
Although organometallic compounds are ubiquitous in nature, synthetic organometallic compounds are generally considered to be toxic or...
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Comparative genomics and gene finding in fungi
In the spring of 2005, we had access to 18 fully sequenced fungal genomes, and more are coming rapidly. New approaches and methods are being...
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3. Lessons from the History of Life
The discussion of life on other worlds is inevitably qualified by the phrase, “life as we know it.” This customary and appropriate caution among...
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1. Introduction
Astrobiology studies the origin, evolution, distribution, and fate of life throughout the universe, with no direct evidence that life exists anywhere...
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8. Ideas of Exotic Forms of Life
Science and speculation have converged at the boundaries of human imagination to conceive of some very exotic states of matter and/or energy that...