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Nano-Se exhibits limited protective effect against heat stress induced poor breast muscle meat quality of broilers compared with other selenium sources
BackgroundAt present, heat stress (HS) has become a key factor that impairs broiler breeding industry, which causes growth restriction and poor meat...
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Effects of Sex Steroids on Innate and Adaptive Immunity
Estrogens and androgens are classically recognized as reproductive sex steroid hormones because of their well-documented effects on reproductive...
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Effects of altering the ratio of C16:0 and cis-9 C18:1 in rumen bypass fat on growth performance, lipid metabolism, intestinal barrier, cecal microbiota, and inflammation in fattening bulls
BackgroundC16:0 and cis -9 C18:1 may have different effects on animal growth and health due to unique metabolism in vivo. This study was investigated...
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Unveiling novel genetic variants in 370 challenging medically relevant genes using the long read sequencing data of 41 samples from 19 global populations
Background: A large number of challenging medically relevant genes (CMRGs) are situated in complex or highly repetitive regions of the human genome,...
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TaqTth-hpRNA: a novel compact RNA-targeting tool for specific silencing of pathogenic mRNA
Pathogenic allele silencing is a promising treatment for genetic hereditary diseases. Here, we develop an RNA-cleaving tool, TaqTth-hpRNA, consisting...
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Transcriptomic responses of Mediterranean sponges upon encounter with symbiont microbial consortia
BackgroundSponges (phylum Porifera) constantly interact with microbes. They graze on microbes from the water column by filter-feeding and they harbor...
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Source and level of dietary iron influence semen quality by affecting inflammation, oxidative stress and iron utilization levels in boars
BackgroundBoars fed a mixed form of inorganic and organic iron in excess of the NRC recommended levels still develop anemia, which suggested that the...
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First trials exploring the potential of phytoseiid mites in managing lychee erinose mite, Aceria litchii (Keifer) (Acari: Eriophyidae), infestations on lychee plants
Phytoseiid mites have been frequently found in association with the lychee erinose mite, Aceria litchii , on lychee plants in Brazil, suggesting that...
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Molecular and immunological studies on Theileria equi and its vector in Egypt
Equine piroplasmosis is not fully understood regarding pathogenicity, prophylaxis, host immune response expression, and specific vectors. Accurately...
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Population genetic structure of Culex tritaeniorhynchus in different types of climatic zones in China
BackgroundCulex tritaeniorhynchus is widely distributed in China, from Hainan Island in the south to Heilongjiang in the north, covering tropical,...
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Saturation genome editing maps the functional spectrum of pathogenic VHL alleles
To maximize the impact of precision medicine approaches, it is critical to identify genetic variants underlying disease and to accurately quantify...
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Saturation genome editing of BAP1 functionally classifies somatic and germline variants
Many variants that we inherit from our parents or acquire de novo or somatically are rare, limiting the precision with which we can associate them...
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Sexually dimorphic oxytocin circuits drive intragroup social conflict and aggression in wild house mice
In nature, both males and females engage in competitive aggressive interactions to resolve social conflicts, yet the behavioral principles guiding...
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The Adaptive Role of Bark in the Diet of Budongo Chimpanzees (Pan troglodytes schweinfurthii)
The ingestion of bark has been observed across the animal kingdom and is well documented in free-ranging chimpanzees. Thus far, the best-supported...
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Expanding the genetic and phenotypic spectrum of Baker–Gordon syndrome: a new de novo SYT1 variant
We report the case of a Spanish pediatric patient with developmental delay, hypotonia, feeding difficulties, visual problems, and hyperkinetic...
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Heat stress affects mammary metabolism by influencing the plasma flow to the glands
BackgroundEnvironmental heat stress (HS) can have detrimental effects on milk production by compromising the mammary function. Mammary plasma flow...
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Functional and evolutionary comparative analysis of the DIR gene family in Nicotiana tabacum L. and Solanum tuberosum L.
BackgroundThe dirigent ( DIR ) genes encode proteins that act as crucial regulators of plant lignin biosynthesis. In Solanaceae species, members of...
