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  1. Nonviral Delivery of Cancer Genetic Vaccines

    The potential use of genetic vaccines to address numerous diseases including cancer is promising, but currently unrealized. Here, we review...
    Steven R. Little, Robert Langer in Gene Therapy and Gene Delivery Systems
    Chapter

  2. Production and Formulation of Adenovirus Vectors

    Adenovirus vectors have attracted considerable interest over the past decade, with ongoing clinical development programs for applications ranging...
    Nedim E. Altaras, John G. Aunins, ... Jayanthi J. Wolf in Gene Therapy and Gene Delivery Systems
    Chapter

  3. Molecular Conjugates

    Molecular conjugates are nanometer-sized entities consisting of synthetic materials (lipids, polycations, targeting agents, and so on) and nucleic...
    Jeremy Heidel, Swaroop Mishra, Mark E. Davis in Gene Therapy and Gene Delivery Systems
    Chapter

  4. Lager brewing yeast

    Lager brewing yeast is a group of closely related strains of Saccharomyces pastorianus/S. carlsbergensis used for lager beer production all over the...
    Yukiko Kodama, Morten C. Kielland-Brandt, Jørgen Hansen in Comparative Genomics
    Chapter

  5. Lentiviral Vectors

    We review the use of lentiviral vectors in current human gene therapy applications that involve genetic modification of nondividing tissues with...
    Nils Loewen, Eric M. Poeschla in Gene Therapy and Gene Delivery Systems
    Chapter

  6. Plasmid Vaccines and Therapeutics: From Design to Applications

    In the late 1980s, Vical and collaborators discovered that the injection into tissues of unformulated plasmid encoding various proteins resulted in...
    Marston Manthorpe, Peter Hobart, ... Alain Rolland in Gene Therapy and Gene Delivery Systems
    Chapter

  7. Adeno-associated Virus as a Gene Therapy Vector: Vector Development, Production and Clinical Applications

    Adeno-associated virus (AAV) has emerged as an attractive vector for gene therapy. AAV vectors have successfully been utilized to promote...
    Joshua C. Grieger, Richard J. Samulski in Gene Therapy and Gene Delivery Systems
    Chapter

  8. Employing protein size in the functional analysis of orthologous proteins, as illustrated with the yeast HOG pathway

    Comparative genomics has provided us with a new handle on the interpretation of protein sequences. The sequencing of numerous fungal genomes has...
    Marcus Krantz, Stefan Hohmann in Comparative Genomics
    Chapter

  9. 3 Biogenesis and cellular dynamics of glycerophospholipids in the yeast Saccharomyces cerevisiae

    In the yeast Saccharomyces cerevisiae, as in other eukaryotes, glycerophospholipids are important cellular components required for growth and cell...
    Ruth Nebauer, Ruth Birner-Grünberger, Günther Daum in Lipid Metabolism and Membrane Biogenesis
    Chapter

  10. 9 Mechanisms and mediators of neutral lipid biosynthesis in eukaryotic cells

    The reactions leading to the biosynthesis of neutral lipids are excellent targets for therapeutic intervention in several disease states including...
    Peter M. Oelkers, Stephen L. Sturley in Lipid Metabolism and Membrane Biogenesis
    Chapter

  11. 4 Defects in cholesterol biosynthesis

    Defects in eight different enzymes of cholesterol biosynthesis that result in serious clinical consequences have been identified. Most of these were...
    Gene C. Ness in Lipid Metabolism and Membrane Biogenesis
    Chapter

  12. Duplication of genes and genomes in yeasts

    The molecular evolution of the group of yeasts closely related to Saccharomyces cerevisiae has been profoundly affected by an ancient polyploidy...
    Simon Wong, Kenneth H. Wolfe in Comparative Genomics
    Chapter

  13. Effects of Sex Steroids on Innate and Adaptive Immunity

    Estrogens and androgens are classically recognized as reproductive sex steroid hormones because of their well-documented effects on reproductive...
    S. Ansar Ahmed, Ebru Karpuzoglu, Deena Khan in Sex Hormones and Immunity to Infection
    Chapter

  14. Comprehensive and deep evaluation of structural variation detection pipelines with third-generation sequencing data

    Background

    Structural variation (SV) detection methods using third-generation sequencing data are widely employed, yet accurately detecting SVs...

    Zhi Liu, Zhi **e, Miaoxin Li in Genome Biology
    Article Open access 15 July 2024

  15. Redundancy in microbiota-mediated suppression of the soybean cyst nematode

    Background

    Soybean cyst nematodes (SCN) as animal parasites of plants are not usually interested in killing the host but are rather focused on...

    Muzammil Hussain, Peixue Xuan, ... Meichun **ang in Microbiome
    Article Open access 15 July 2024

  16. Coronary periarteritis and pericarditis are rare but distinct manifestations of heart involvement in IgG4-related disease: a retrospective cohort study

    Background

    The heart can be involved in immunoglobulin (Ig)-G4-related disease (IgG4-RD). This study aimed to summarize the clinical features and...

    Tianrui Hua, Juan Du, ... Wen Zhang in Orphanet Journal of Rare Diseases
    Article Open access 15 July 2024

  18. Long-term biotic homogenization in the East African Rift System over the last 6 million years of hominin evolution

    Eastern Africa preserves the most complete record of human evolution anywhere in the world but we have little knowledge of how long-term...

    John Rowan, Andrew Du, ... Jason M. Kamilar in Nature Ecology & Evolution
    Article 15 July 2024
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