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The Broad Spectrum of Responses to Oxidative Stress in Proliferating Cells
Proliferating mammalian cells exhibit a broad spectrum of responses to oxidative stress, depending on the stress level encountered. Very low levels...
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Low Molecular Weight Antioxidants
Low molecular weight antioxidants are an important part of the antioxidative defense mechanisms of cells and organisms. This chapter gives a short...
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Environmental Oxidative Stress – Environmental Sources of ROS
Environmental factors are known sources for oxidative stress. In consequence of the numerous influences that define our environment, environmental...
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Endogenous Oxidant-Generating Systems
Although organisms respiring air oxygen use their energy sources in an optimal way they are threatened by the compulsory formation of reactive oxygen...
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Glutathione
Glutathione is the most abundant non-protein thiol in cells. It is a tripeptide with two important structural features: the thiol group and the...
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Modulation of Cellular Signaling Processes by Reactive Oxygen Species
Exposure of cells to reactive oxygen species (ROS) may result not only in cell death by excessive oxidation of biomolecules but also cause the...
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Chemical Modifications of Biomolecules by Oxidants
There is strong evidence in support of the oxidation of biomolecules during normal physiology and under conditions of environmental or pathological...
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DNA Repair: Mechanisms and Measurements
The early findings that significant amounts of modifications are induced to the cellular DNA both spontaneously and as a consequence of metabolism...
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Mitochondrial Free Radical Production, Antioxidant Defenses and Cell Signaling
Mitochondria were classically recognized as the organelles that produce the energy required to drive the endergonic processes of cell life, but now...
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Protein Repair and Degradation
Protein oxidation is one of the important processes taking place during oxidative stress. Numerous amino acids can be modified within proteins...
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Superoxide Dismutases and Catalase
Superoxide dismutases (SODs) and catalase represent the primary enzymatic defense against reactive oxygen species. Both enzymes are present in...
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Independent and joint associations of multiple metals exposure with vital capacity index: a cross-sectional study in Chinese children and adolescents
ObjectiveThe current study aimed to explore the relationships between urinary metals and vital capacity index (VCI) in 380 children and adolescents...
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Exposure to heavy metals in utero and autism spectrum disorder at age 3: a meta-analysis of two longitudinal cohorts of siblings of children with autism
BackgroundAutism spectrum disorder (ASD) is a prevalent and heterogeneous neurodevelopmental disorder. Risk is attributed to genetic and prenatal...
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Musculoskeletal Health and Work: Development and Internal–External Cross-Validation of a Model to Predict Risk of Work Absence and Presenteeism in People Seeking Primary Healthcare
PurposeTo develop and validate prediction models for the risk of future work absence and level of presenteeism, in adults seeking primary healthcare...
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Evaluation of mortality among Marines, Navy personnel, and civilian workers exposed to contaminated drinking water at USMC base Camp Lejeune: a cohort study
BackgroundDrinking water at U.S. Marine Corps Base (MCB) Camp Lejeune, North Carolina was contaminated with trichloroethylene and other industrial...
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Double Trouble! Do Workplace Supports Mitigate Lost Productivity for Young Workers with Both Severe Rheumatic Diseases and Depressive Symptoms?
BackgroundThe objectives of this longitudinal study were to understand how comorbid rheumatic disease and depression symptoms were associated with...
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Machine learning predicts peak oxygen uptake and peak power output for customizing cardiopulmonary exercise testing using non-exercise features
PurposeCardiopulmonary exercise testing (CPET) is considered the gold standard for assessing cardiorespiratory fitness. To ensure consistent...
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Longitudinal changes in cardiovascular disease–related proteins in welders
ObjectiveOccupational exposure to welding fumes is linked to a higher risk of cardiovascular disease; however, the threshold exposure level is...
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Emergency room visits (ERVs) among occupational groups associated with ambient conditions in Taiwan
ObjectiveThis population-based study explored emergency room visits (ERVs) from all-causes, circulatory and respiratory diseases among different...
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Is informal telework a threat to work-family reconciliation? Comparing the implications of formal and informal telework for work-family conflicts
The study analyses the relationship between formal and informal telework and work-family conflicts using the job-demands and resources (JD-R) model....
