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  2. Charge Transport and Catalysis by Molecules Confined in Polymeric Materialsand Application to Future Nanodevices for Energy Conversion

    Polymeric materials confining functional molecules are one of the most promising materials for designing nanodevices for energy conversion, e.g.,...
    Masayuki Yagi, Masao Kaneko in Emissive Materials Nanomaterials
    Chapter

  3. Functions of Rab GTPases in organelle biogenesis

    Rab GTPases regulate diverse aspects of the biogenesis of secretory and endocytic organelles. The conformational changes that accompany GTP binding...
    Christopher G. Burd, Ruth N. Collins in Regulatory Mechanisms of Intracellular Membrane Transport
    Chapter

  4. Introduction: Regulatory processes, an emerging feature in intracellular membrane traffic

    The subject of this volume is the molecular mechanism of the intracellular membrane trafficking, a central eukaryotic cell biological process. In the...
    Sirkka Keränen, Jussi Jäntti in Regulatory Mechanisms of Intracellular Membrane Transport
    Chapter

  5. Biophysical characterization of the phase separation of TDP-43 devoid of the C-terminal domain

    Background

    Frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-TDP), amyotrophic lateral sclerosis (ALS) and limbic-predominant...

    Tommaso Staderini, Alessandra Bigi, ... Fabrizio Chiti in Cellular & Molecular Biology Letters
    Article Open access 13 July 2024

  6. Advanced Targeting Strategies for Murine Retroviral and Adeno-associated Viral Vectors

    Targeted gene delivery involves broadening viral tropism to infect previously nonpermissive cells, replacing viral tropism to infect a target cell...
    Julie H. Yu, David V. Schaffer in Gene Therapy and Gene Delivery Systems
    Chapter

  7. Nonviral Delivery of Cancer Genetic Vaccines

    The potential use of genetic vaccines to address numerous diseases including cancer is promising, but currently unrealized. Here, we review...
    Steven R. Little, Robert Langer in Gene Therapy and Gene Delivery Systems
    Chapter

  8. Production and Formulation of Adenovirus Vectors

    Adenovirus vectors have attracted considerable interest over the past decade, with ongoing clinical development programs for applications ranging...
    Nedim E. Altaras, John G. Aunins, ... Jayanthi J. Wolf in Gene Therapy and Gene Delivery Systems
    Chapter

  9. Molecular Conjugates

    Molecular conjugates are nanometer-sized entities consisting of synthetic materials (lipids, polycations, targeting agents, and so on) and nucleic...
    Jeremy Heidel, Swaroop Mishra, Mark E. Davis in Gene Therapy and Gene Delivery Systems
    Chapter

  10. Regulation of SNARE assembly by protein phosphorylation

    Protein phosphorylation is emerging as an important regulatory mechanism that controls the secretory pathway. It enables coupling between the...
    Adina Weinberger, Jeffrey E. Gerst in Regulatory Mechanisms of Intracellular Membrane Transport
    Chapter

  11. Molecular mechanisms in clathrin-mediated membrane budding

    Clathrin-coated vesicles (CCVs) form at the plasma membrane where they select cargo for endocytic entry into cells. CCVs also form at the trans-Golgi...
    Brigitte Ritter, Peter S. McPherson in Regulatory Mechanisms of Intracellular Membrane Transport
    Chapter

  12. Tethering proteins in membrane traffic

    In eukaryotic cells, protein secretion and the transport of materials between membrane-bounded organelles require efficient and accurate delivery of...
    Sarah Chu, Wei Guo in Regulatory Mechanisms of Intracellular Membrane Transport
    Chapter

  13. Regulation of exocytotic events by centrosome-analogous structures

    Centrosomes, spindle pole bodies, and related structures, generally termed microtubule organising centres (MTOCs; Pickett-Heaps 1969), are best...
    Christof Taxis, Michael Knop in Regulatory Mechanisms of Intracellular Membrane Transport
    Chapter

  14. Spiro Compounds for Organic Electroluminescence and Related Applications

    A comprehensive review about functional spiro compounds, their synthesis, physical properties and applications in optoelectronic devices is given.
    R. Pudzich, T. Fuhrmann-Lieker, J. Salbeck in Emissive Materials Nanomaterials
    Chapter

  15. Polyphenylene-type Emissive Materials: Poly(para-phenylene)s,Polyfluorenes, and Ladder Polymers

    This ‘chapter’ reviews the synthesis of the various classes of polyphenylene-based materials that have been investigated as active materials in...
    Andrew C. Grimsdale, Klaus Müllen in Emissive Materials Nanomaterials
    Chapter

  16. Conducting Polymer Nanomaterials and Their Applications

    A paradigm shift takes place in the fabrication of conducting polymers from bulky features with microsize to ultrafine features with nanometer range....
    Jyongsik Jang in Emissive Materials Nanomaterials
    Chapter

  17. Exploring the complexity of EEG patterns in Parkinson’s disease

    Parkinson’s disease (PD) is a progressive neurodegenerative disorder primarily associated with motor dysfunctions. By the time of definitive...

    Lorenzo Nucci, Francesca Miraglia, ... Fabrizio Vecchio in GeroScience
    Article 13 July 2024

  18. Progress and perspectives of metabolic biomarkers in human aortic dissection

    Background

    Aortic dissection (AD) significantly threated human cardiovascular health, extensive clinical-scientific research programs have been...

    Gaohang Mu, **angyu Cao, ... Zhenya Shen in Metabolomics
    Article 13 July 2024

  19. Adeno-associated Virus as a Gene Therapy Vector: Vector Development, Production and Clinical Applications

    Adeno-associated virus (AAV) has emerged as an attractive vector for gene therapy. AAV vectors have successfully been utilized to promote...
    Joshua C. Grieger, Richard J. Samulski in Gene Therapy and Gene Delivery Systems
    Chapter

  20. Lentiviral Vectors

    We review the use of lentiviral vectors in current human gene therapy applications that involve genetic modification of nondividing tissues with...
    Nils Loewen, Eric M. Poeschla in Gene Therapy and Gene Delivery Systems
    Chapter
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