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GC × GC-HRMS with complementary ionization methods in the suspect screening analysis of fragrance allergens: overwhelming or justified?
Modern gas chromatography-mass spectrometry (GC–MS) allows for the analysis of complex samples, such as fragrances. However, identifying all the...
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Pipette-tip solid-phase extraction coupled with matrix-assisted laser desorption/ionization mass spectrometry enables rapid and high-throughput analysis of antidepressants in rat serum
Therapeutic drug monitoring is essential for ensuring the efficacy and safety of medications. This study introduces a streamlined approach that...
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Engineering for a clear image: a comparative focus on accommodation
The eye requires the ability to focus images near and far and throughout evolution numerous mechanisms have developed to allow this accommodation....
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Inter-zonal epithelial thickness differences for early keratoconus detection using optical coherence tomography
PurposeTo develop and test a parameter for early keratoconus screening by quantifying the localized epithelial thickness differences in keratoconic...
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Assessing large language models’ accuracy in providing patient support for choroidal melanoma
PurposeThis study aimed to evaluate the accuracy of information that patients can obtain from large language models (LLMs) when seeking answers to...
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Real world treatment outcomes in polypoidal choroidal vasculopathy in a Caucasian population of British ethnicity
PurposeTo assess treatment response of Polypoidal choroidal vasculopathy (PCV) in a Caucasian population of British ethnicity with intravitreal...
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Posterior corneal stability after small incision lenticule extraction with different optical zones
BackgroundTo assess the changes in the posterior corneal surface following small incision lenticule extraction (SMILE) with different optical zones.
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A stochastic approach for parameter optimization of feature detection algorithms for non-target screening in mass spectrometry
Feature detection plays a crucial role in non-target screening (NTS), requiring careful selection of algorithm parameters to minimize false positive...
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Development of a supramolecular solvent–based extraction method for application to quantitative analyses of a wide range of organic contaminants in indoor dust
This study investigates the efficacy of supramolecular solvent (SUPRAS) in extracting a diverse spectrum of organic contaminants from indoor dust....
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Progress, applications, and challenges in high-throughput effect-directed analysis for toxicity driver identification — is it time for HT-EDA?
The rapid increase in the production and global use of chemicals and their mixtures has raised concerns about their potential impact on human and...
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Quantitative comparison of bile acid glucuronides sub-metabolome between intrahepatic cholestasis and healthy pregnant women
Because of the pathological indication and the physiological functions, bile acids (BAs) have occupied the research hotspot in recent decades....
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Clinical Metagenomic Next-Generation Sequencing for Diagnosis of Central Nervous System Infections: Advances and Challenges
Central nervous system (CNS) infections carry a substantial burden of morbidity and mortality worldwide, and accurate and timely diagnosis is...
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Establishment of a multi-line immunochromatography based on magnetic nanoparticles for simultaneous screening of multiple biomarkers
Biomarkers screening is a benefit approach for early diagnosis of major diseases. In this study, magnetic nanoparticles (MNPs) have been utilized as...
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Rapid analysis of untreated food samples by gel loading tip spray ionization mass spectrometry
Rapid, efficient, versatile, easy-to-use, and non-expensive analytical approaches are globally demanded for food analysis. Many ambient ionization...
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Situs inversus partialis (levocardia): an incidental discovery of an extremely rare case during the autopsy of a female with suicidal poisoning
BackgroundSitus inversus is a rare congenital anomaly. In this condition, the abdominal and chest organs are positioned in reverse, a mirror image of...
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Identification of Immunodominant Epitopes of Dengue Virus 2 Envelope and NS1 Proteins: Evaluating the Diagnostic Potential of a Synthetic Peptide
Background and ObjectiveDengue is a major infectious disease with potential for outbreaks and epidemics. A specific and sensitive diagnosis is a...
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Combination of real-time and hyphenated mass spectrometry for improved characterisation of exhaled breath biomarkers in clinical research
Exhaled breath volatilomics is a powerful non-invasive tool for biomarker discovery in medical applications, but compound annotation is essential for...
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Optimizing open-angle glaucoma risk assessment in patients with retinal vein occlusions
PurposeTo evaluate factors associated with the diagnosis of open-angle glaucoma (OAG) after a retinal vein occlusion (RVO).
DesignRetrospective,...
