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Effects of Sex Steroids on Innate and Adaptive Immunity
Estrogens and androgens are classically recognized as reproductive sex steroid hormones because of their well-documented effects on reproductive...
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Sex-specific role of high-fat diet and stress on behavior, energy metabolism, and the ventromedial hypothalamus
BackgroundScientific evidence highlights the influence of biological sex on the relationship between stress and metabolic dysfunctions. However,...
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Interrelationship between thyroid hormones and reduced renal function, a review article
BackgroundUnderstanding the relationship of thyroid hormones with the development of chronic kidney disease (CKD) has important clinical implications...
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Efficient leather spreading operations by dual-arm robotic systems
To achieve precise gras** and spreading of irregular sheet-like soft objects (such as leather) by robots, this study addresses several challenges,...
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Large-scale whole-exome sequencing analyses identified protein-coding variants associated with immune-mediated diseases in 350,770 adults
The genetic contribution of protein-coding variants to immune-mediated diseases (IMDs) remains underexplored. Through whole exome sequencing of 40...
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I/O-efficient iterative matrix inversion with photonic integrated circuits
Photonic integrated circuits have been extensively explored for optical processing with the aim of breaking the speed and energy...
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JWH-182: a safe and effective synthetic cannabinoid for chemotherapy-induced neuropathic pain in preclinical models
Chemotherapy-induced neuropathic pain (CINP), a condition with unmet treatment needs, affects over half of cancer patients treated with...
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Effect of recurrent severe insulin-induced hypoglycemia on the cognitive function and brain oxidative status in the rats
BackgroundEpisodes of recurrent or severe hypoglycemia can occur in patients with diabetes mellitus, insulinoma, neonatal hypoglycemia, and...
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Tirzepatide Improved Health-Related Quality of Life Compared with Insulin Lispro in Basal Insulin-Treated Adults with Type 2 Diabetes and Inadequate Glycaemic Control: A Randomised Controlled Phase 3b Trial (SURPASS-6)
IntroductionPatients with type 2 diabetes (T2D) who require intensification of basal insulin therapy need treatment options that can improve their...
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Efficient and reproducible generation of human iPSC-derived cardiomyocytes and cardiac organoids in stirred suspension systems
Human iPSC-derived cardiomyocytes (hiPSC-CMs) have proven invaluable for cardiac disease modeling and regeneration. Challenges with quality,...
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Diaph1 knockout inhibits mouse primordial germ cell proliferation and affects gonadal development
BackgroundExploring the molecular mechanisms of primordial germ cell (PGC) migration and the involvement of gonadal somatic cells in gonad...
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Laboratory infrared spectra and fragmentation chemistry of sulfur allotropes
Sulfur is one of six life-essential elements, but its path from interstellar clouds to planets and their atmospheres is not well known. Astronomical...
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Association of Changes in A1C Following Continuous Glucose Monitoring Acquisition in People with Sub-Optimally Treated Type 2 Diabetes Taking GLP-1 RA Therapy
IntroductionBoth glucagon-like peptide-1 receptor agonists (GLP-1 RA) and continuous glucose monitoring (CGM) improve glycemia in patients with type...
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A One Health framework for exploring zoonotic interactions demonstrated through a case study
The eco-epidemiology of zoonoses is often oversimplified to host-pathogen interactions while findings derived from global datasets are rarely...
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Safety and Psychological Outcomes of Tandem t:Slim X2 Insulin Pump with Control-IQ Technology in Children, Adolescents, and Young Adults with Type 1 Diabetes: A Systematic Review
The Tandem t:slim X2 insulin pump is a second-generation automated insulin delivery system with Control-IQ technology. It consists of an X2 insulin...
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Impact of bedaquiline regimen on the treatment success rates of multidrug-resistant tuberculosis patients in Egypt
Bedaquiline (BDQ), an innovative anti-tuberculous (TB) agent, has attracted attention for its potential effectiveness against drug-resistant TB. This...
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Temporal dynamics of climate change exposure and opportunities for global marine biodiversity
Climate change is exposing marine species to unsuitable temperatures while also creating new thermally suitable habitats of varying persistence....
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Predictors of response to Radioactive Iodine Therapy in Intermediate and high risk patients with papillary thyroid carcinoma
BackgroundRadioactive iodine (RAI) therapy is the standard treatment approach after total thyroidectomy in patients with papillary thyroid carcinoma...
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Assessment of glycemic susceptibility across multiple urological and reproductive disorders
ObjectiveTo test the glycemic susceptibility in three urological cancers and eight urological/reproductive diseases using the Mendelian randomization...
