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Effects of Sex Steroids on Innate and Adaptive Immunity
Estrogens and androgens are classically recognized as reproductive sex steroid hormones because of their well-documented effects on reproductive... -
Methylprednisolone Modulates the Tfr/Tfh ratio in EAE-Induced Neuroinflammation through the PI3K/AKT/FoxO1 and PI3K/AKT/mTOR Signalling Pathways
Methylprednisolone (MP) is a potent glucocorticoid that can effectively inhibit immune system inflammation and brain tissue damage in Multiple...
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Efficacy of tibial cortex transverse transport in treating diabetic foot ulcer and its effect on serum omentin-1 and irisin levels
ObjectiveDiabetic foot ulcer (DFU) is a common and debilitating complication of diabetes that is associated with an increased risk of lower-limb...
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CYP24A1 Deficiency Mimicking Other Causes of Hypercalciuria and Nephrocalcinosis: A Case Report
In this report, we discuss the case of a 54-year-old patient attending our department with osteopenia, urolithiasis, significant hypercalciuria, and...
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Association between carpal height ratio and ulnar variance in normal wrist radiography
IntroductionThe wrist joint is a complex anatomical structure, and various radiographic parameters are utilized to assess its normal alignment and...
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Emodin alleviates intestinal ischemia–reperfusion injury through antioxidant stress, anti-inflammatory responses and anti-apoptosis effects via Akt-mediated HO-1 upregulation
BackgroundIntestinal ischemia–reperfusion (I/R) injury is a severe vascular emergency. Previous research indicated the protective effects of Emodin...
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The association between the neutrophil-to-lymphocyte ratio and type 2 diabetes mellitus: a cross-sectional study
BackgroundType 2 diabetes mellitus (T2DM) is a prevalent chronic disease often accompanied by low-grade inflammation. Recently, the...
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The incidence of fractures in children under two years of age: a systematic review
BackgroundEpidemiological research on fractures in children under the age of two is of great importance to help understand differences between...
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Effect of changes in motor skill induced by educational video program to decrease lower-limb joint load during cutting maneuvers: based on musculoskeletal modeling
BackgroundThis study investigated the effects of changes in motor skills from an educational video program on the kinematic and kinetic variables of...
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New studies with stable gastric pentadecapeptide protecting gastrointestinal tract. significance of counteraction of vascular and multiorgan failure of occlusion/occlusion-like syndrome in cytoprotection/organoprotection
Since the early 1990s, when Robert’s and Szabo’s cytoprotection concept had already been more than one decade old, but still not implemented in...
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Evaluation of fragility fracture risk using deep learning based on ultrasound radio frequency signal
BackgroundIt was essential to identify individuals at high risk of fragility fracture and prevented them due to the significant morbidity, mortality,...
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Experimental study on the biomechanical stability of complex acetabular fractures in the quadrilateral area: application of a dynamic anterior titanium-plate screw system
Background and objectiveComplex acetabular fractures involving quadrilateral areas are more challenging to treat during surgery. To date, there has...
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Operative treatment of isolated epiphyseal fracture of the distal fibula: 1 case report and literature review
Pediatric ankle injuries are common; ankle epiphyseal fractures are also common in children. But isolated distal epiphyseal fibular fractures of the...
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Protective effects of ginsenosides on ulcerative colitis: a meta-analysis and systematic review to reveal the mechanisms of action
BackgroundUlcerative colitis (UC) is a chronic inflammatory disease of the colon. Ginsenoside may be an ideal agent for UC treatment. However, its...
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Comparative effects of different treatments based on the levonorgestrel intrauterine system in endometrial carcinoma and endometrial hyperplasia patients: a network meta-analysis
ObjectiveLevonorgestrel intrauterine system (LNG-IUS) has been widely used in patients with endometrial carcinoma (EC), endometrial hyperplasia...
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INFLA score: a novel inflammatory marker for assessing cardiometabolic disease risk in obese individuals
BackgroundThe low-grade inflammation score (INFLA-score) is a composite index that assesses chronic inflammatory status using multiple inflammatory...
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Challenges in the management of patients with HNF1B MODY and multisystem manifestations: the cases of two adolescent boys
IntroductionHepatocyte nuclear factor-1 beta ( HNF1B ) encodes a homeodomain-containing transcription factor, which is expressed early in...