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Effects of Sex Steroids on Innate and Adaptive Immunity
Estrogens and androgens are classically recognized as reproductive sex steroid hormones because of their well-documented effects on reproductive...
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Sodium-Glucose Cotransporter 2 Inhibitors During Cancer Therapy: Benefits, Risks, and Ongoing Clinical Trials
Purpose of reviewThe goal of this paper is to summarize the data pertaining to the use of sodium-glucose cotransporter-2 inhibitors (SGLT-2i) for the...
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De-novo ATR-16 syndrome associated with inherited hemoglobin Evanston causing HbH phenotype: a rare occurrence
Abnormality of three α-globin genes, either deletion or point mutation results in symptomatic Hemoglobin H (HbH) phenotype. Most of such cases of...
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Fasting in combination with the cocktail Sorafenib:Metformin blunts cellular plasticity and promotes liver cancer cell death via poly-metabolic exhaustion
PurposeDual-Interventions targeting glucose and oxidative metabolism are receiving increasing attention in cancer therapy. Sorafenib (S) and...
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ESRP1-mediated biogenesis of circPTPN12 inhibits hepatocellular carcinoma progression by PDLIM2/ NF-κB pathway
BackgroundEmerging evidence indicates the pivotal involvement of circular RNAs (circRNAs) in cancer initiation and progression. Understanding the...
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Exploration of helpful elements contributing to engage in physical activity in patients with cancer
PurposeAlthough there are many reported benefits of physical activity for patients with cancer (e.g., improving quality of life), many patients with...
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The influence of the vaginal ecosystem on vaginitis, bacterial vaginosis, and sexually transmitted diseases: an epidemiological study and literature review
PurposeThis study aimed to demonstrate the correlation between altered balance of the vaginal ecosystem and increased risk of vaginitis, bacterial...
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N6-methyladenosine modification of circMARK2 enhances cytoplasmic export and stabilizes LIN28B, contributing to the progression of Wilms tumor
BackgroundThe potential involvement of circular RNAs (circRNAs) and N 6 -methyladenosine (m 6 A) modification in the progression of Wilms tumor (WT) has...
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Survival of advanced/recurrent gastrointestinal stromal tumors treated with tyrosine kinase inhibitors in Taiwan: a nationwide registry study
BackgroundMost gastrointestinal stromal tumors (GISTs) harbor c-KIT or PDGFRA mutations. Administration of tyrosine kinase inhibitors (TKIs) has...
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Prognostic value of surgical resection over biopsy in elderly patients with glioblastoma: a meta-analysis
PurposeMaximal-safe resection has been shown to improve overall survival in elderly patients with glioblastoma in observational studies, however, the...
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A systematic review on the effectiveness of robot-assisted minimally invasive gastrectomy
BackgroundRobot-assisted minimally invasive gastrectomy (RAMIG) is increasingly used as a surgical approach for gastric cancer. This study assessed...
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Impact of baseline body composition on prognostic outcomes in urological malignancies treated with immunotherapy: a pooled analysis of 10 retrospective studies
ObjectiveNumerous epidemiological investigations have explored the impact of body composition on the effectiveness of immune checkpoint inhibitors...
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Childhood asthma and mould in homes—A meta-analysis
Asthma is a multifaceted and multicausal disease. Childhood asthma is strongly influenced by genetic traits and is characterized by hyperreactivity...
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Sperm DNA fragmentation and infertility: a narrative review
PurposeThe purpose of this narrative review is to provide a practical understanding of sperm DNA fragmentation (SDF) in the management of male...
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Anti-cancer potential of casein and its derivatives: novel strategies for cancer treatment
Cancer is one of the leading causes of death worldwide, with over 10 million fatalities annually. While tumors can be surgically removed and treated...
