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The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
Since its discovery in 1986, as the first tumor suppressor gene, the retinoblastoma gene (Rb) has been extensively studied. Numerous biochemical and...
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Senescence and Cell Cycle Control
In response to various stresses, such as telomere shortening during continuous proliferation, oxidative stress, DNA damage and aberrant oncogene...
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Control of Cell Proliferation and Growth by Myc Proteins
Myc proteins act as signal transducers that alter cell proliferation in dependence on signals from the extracellular environment. In normal cells,...
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Checkpoint and Coordinated Cellular Responses to DNA Damage
The DNA damage and replication checkpoints are signaling mechanisms that regulate and coordinate cellular responses to genotoxic conditions. The...
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Regulation of S Phase
Regulation of DNA replication is critical for accurate and timely dissemination of genomic material to daughter cells. The cell uses a variety of...
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Mouse Models of Cell Cycle Regulators: New Paradigms
In yeast, a single cyclin-dependent kinase (Cdk) is able to regulate diverse cell cycle transitions (S and M phases) by associating with multiple...
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G1 Phase: Components, Conundrums, Context
A eukaryotic cell must coordinate DNA synthesis and chromosomal segregation to generate a faithful replica of itself. These events are confined to...
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The ubiquitin-proteasome pathway in cell cycle control
Ubiquitin-mediated proteolysis is one of the key mechanisms underlying cell cycle control. The removal of barriers posed by accumulation of...
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Protein Kinases Involved in Mitotic Spindle Checkpoint Regulation
A number of checkpoint controls function to preserve the genome by restraining cell cycle progression until prerequisite events have been properly...
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The Centrosome Cycle
Centrosomes are dynamic organelles involved in many aspects of cell function and growth. Centrosomes act as microtubule organizing centers, and...
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Cell Cycle Regulation in Mammalian Germ Cells
Meiosis is a unique form of cellular division by which a diploid cell produces genetically distinct haploid gametes. Initiation and regulation of...
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Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor
Cancer is a complex syndrome of diseases characterized by the increased abundance of cells that disrupts the normal tissue architecture within...
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USP8 promotes the tumorigenesis of intrahepatic cholangiocarcinoma via stabilizing OGT
Ubiquitination was considered to be a crucial factor in intrahepatic cholangiocarcinoma (iCCA) development. Herein, we identified Ubiquitin-specific...
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Enhanced cancer cell proliferation and aggressive phenotype counterbalance in breast cancer with high BRCA1 gene expression
PurposeWhile comprehensive research exists on the mutation of the DNA repair gene BRCA1 , limited information is available regarding the clinical...
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Endoscopic ultrasound-guided hepaticogastrostomy vs. antegrade metal stent placement kee** an access route in patients with malignant biliary obstruction
BackgroundFew studies have compared endoscopic ultrasound (EUS)-guided hepaticogastrostomy (HGS) with EUS-guided antegrade metal stent placement...
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Normal ovarian sizes on MRI in pediatric patients: a preliminary study
BackgroundOvarian enlargement is one of several findings of pathology, including ovarian torsion. With increasing use of MRI for acute abdominal pain...
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DNMT3A-R882: a mutation with many paradoxes
Understanding the underlying mechanism of acute myeloid leukemia (AML) has led to the discovery of novel biomarkers to help predict, treat and...
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Elemental Composition and Health Risk Assessment of Deep-Sea Teleost’s of the Levantine Basin
The determination of metal(loid) (As, Fe, Al, Sr, Zn, Pb, Mn, Cu, Cr, and Cd) levels in the muscle tissue of 23 different deep-sea bony fish sampled...
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Deciphering glutamine metabolism patterns for malignancy and tumor microenvironment in clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer characterized by metabolic reprogramming. Glutamine metabolism is...
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Factors related to accurate clinicians’ prediction of survival: an international multicenter study in East Asia
PurposeRecent guidelines for prognostic evaluation recommend clinicians’ prediction of survival (CPS) for survival prediction in patients with...