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Introduction
Genetic algorithms (GAs) are powerful search techniques based on principles of evolution. They are now widely applied to solve problems in many...
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Linkage Learning Genetic Algorithm
In order to handle linkage evolution and to tackle the ordering problem, Harik [47] took Holland’s call [53] for the evolution of tight linkage quite...
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Preliminaries: Assumptions and the Test Problem
After introducing the background and motivation of the linkage learning genetic algorithm, we will start to improve and understand the linkage...
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Content Based Image Compression in Biomedical High-Throughput Screening Using Artificial Neural Networks
Biomedical High-Throughput Screening (HTS) requires specific properties of image compression. Particularly especially when archiving a huge number of...
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Discriminative Clustering of Yeast Stress Response
When a yeast cell is challenged by a rapid change in the conditions, be it temperature, osmolarity, pH, nutrient or other, it starts a genome stress...
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Medical Bioinformatics: Detecting Molecular Diseases with Case-Based Reasoning
Based on the Human Genome Project, the new interdisciplinary subject of bioinformatics has become an important research topic during the last decade....
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Transcriptome analysis in abiotic stress conditions in higher plants
Drought, high salinity, and low temperature are major environmental factors that limit plant productivity. Plants respond and adapt to these stresses...
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Signal transduction in plant cold acclimation
Temperate plants respond to low temperature by activating a cold acclimation program leading to enhanced tolerance to freezing temperatures. This...
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Plant salt tolerance
Soil salinity adversely affects crop productivity and quality. The success of breeding programs aimed at salinity tolerant crop varieties is limited...
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Plant responses to heat stress
The heat stress response is characterized by inhibition of normal transcription and translation, higher expression of heat shock proteins (hsps) and...
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Sensors of abiotic stress in Synechocystis
Systematic mutagenesis of histidine kinases in combination with DNA microarray technology has allowed us to identify sensors for cold, hyperosmotic...
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Abscisic acid signalling
Signalling of abscisic acid (ABA) in plants is characterized by an amazing number of secondary messengers that are part of the pathway or modulate...
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12 Baker’s Yeast: a rising foundation for eukaryotic sphingolipid-mediated cell signaling
Saccharomyces cerevisiae has been an invaluable tool for the dissection of sphingolipid metabolic pathways and cloning of enzymes involved in...
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1 Phospholipid synthesis in mammalian cells
Phospholipids are the main components of biological membranes and as such act as the major permeability barrier between cells and the extracellular...
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2 Phospholipid synthesis and dynamics in plant cells
Phospholipids represent the second family of lipids after the galactolipids in photosynthetic tissues and the first in non-photosynthetic tissues....
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11 Plant sphingolipids
Plants contain a multiplicity of sphingolipid metabolites, such as long-chain bases, long-chain base phosphates, ceramides, glycosylceramides,...
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5 Sterol metabolism and functions in higher plants
Higher plants synthesize a bewildering array of sterols, with sitosterol, stigmasterol, and 24-methylcholesterol as major compounds. All plant...
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6 Sterol biochemistry and regulation in the yeast Saccharomyces cerevisiae
Saccharomyces cerevisiae has been a major model system for the study of sterol biosynthesis and function. All of the genes encoding the enzymes...
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7 Mammalian ACAT and DGAT2 gene families
Mammalian isozymes of ACAT, DGAT, and MGAT are encoded by the ACAT and DGAT2 gene families. These enzymes catalyze the synthesis of neutral lipid...