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Inexpensive and colorimetric RNA detection at ambient temperature with a cell-free protein synthesis platform
While many proposals of paper-based diagnostics utilize cell-free gene expression systems, these assays oftentimes suffer from the need for...
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SHR-A1811 (antibody-drug conjugate) in advanced HER2-mutant non-small cell lung cancer: a multicenter, open-label, phase 1/2 study
A dose-escalation and expansion, phase 1/2 study (ClinicalTrials.gov, NCT04818333) was conducted to assess the novel antibody-drug conjugate...
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Introduction
Genetic algorithms (GAs) are powerful search techniques based on principles of evolution. They are now widely applied to solve problems in many... -
Linkage Learning Genetic Algorithm
In order to handle linkage evolution and to tackle the ordering problem, Harik [47] took Holland’s call [53] for the evolution of tight linkage quite... -
Preliminaries: Assumptions and the Test Problem
After introducing the background and motivation of the linkage learning genetic algorithm, we will start to improve and understand the linkage... -
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Content Based Image Compression in Biomedical High-Throughput Screening Using Artificial Neural Networks
Biomedical High-Throughput Screening (HTS) requires specific properties of image compression. Particularly especially when archiving a huge number of... -
Discriminative Clustering of Yeast Stress Response
When a yeast cell is challenged by a rapid change in the conditions, be it temperature, osmolarity, pH, nutrient or other, it starts a genome stress... -
Medical Bioinformatics: Detecting Molecular Diseases with Case-Based Reasoning
Based on the Human Genome Project, the new interdisciplinary subject of bioinformatics has become an important research topic during the last decade.... -
Transcriptome analysis in abiotic stress conditions in higher plants
Drought, high salinity, and low temperature are major environmental factors that limit plant productivity. Plants respond and adapt to these stresses... -
Signal transduction in plant cold acclimation
Temperate plants respond to low temperature by activating a cold acclimation program leading to enhanced tolerance to freezing temperatures. This... -
Plant salt tolerance
Soil salinity adversely affects crop productivity and quality. The success of breeding programs aimed at salinity tolerant crop varieties is limited... -
Plant responses to heat stress
The heat stress response is characterized by inhibition of normal transcription and translation, higher expression of heat shock proteins (hsps) and... -
Sensors of abiotic stress in Synechocystis
Systematic mutagenesis of histidine kinases in combination with DNA microarray technology has allowed us to identify sensors for cold, hyperosmotic... -
Abscisic acid signalling
Signalling of abscisic acid (ABA) in plants is characterized by an amazing number of secondary messengers that are part of the pathway or modulate... -
12 Baker’s Yeast: a rising foundation for eukaryotic sphingolipid-mediated cell signaling
Saccharomyces cerevisiae has been an invaluable tool for the dissection of sphingolipid metabolic pathways and cloning of enzymes involved in... -
1 Phospholipid synthesis in mammalian cells
Phospholipids are the main components of biological membranes and as such act as the major permeability barrier between cells and the extracellular... -
2 Phospholipid synthesis and dynamics in plant cells
Phospholipids represent the second family of lipids after the galactolipids in photosynthetic tissues and the first in non-photosynthetic tissues.... -
Modeling Calcium Waves
We present an introduction to the mathematics of calcium waves, both intracellular and intercellular. After a discussion of the earlier models I... -
Regulation of IP 3 Receptors by IP 3 and Ca 2+
Inositol 1,4,5-trisphosphate ( IP 3) receptors are intracellular Ca 2+ channels that mediate release of Ca 2+ from intracellular stores. The channels...