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SHR-A1811 (antibody-drug conjugate) in advanced HER2-mutant non-small cell lung cancer: a multicenter, open-label, phase 1/2 study
A dose-escalation and expansion, phase 1/2 study (ClinicalTrials.gov, NCT04818333) was conducted to assess the novel antibody-drug conjugate...
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Inexpensive and colorimetric RNA detection at ambient temperature with a cell-free protein synthesis platform
While many proposals of paper-based diagnostics utilize cell-free gene expression systems, these assays oftentimes suffer from the need for...
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Brominated Flame Retardants in the Great Lakes
Brominated flame retardants in the Great Lakes have not been as well studied as many of the polychlorinated pollutants, especially PCBs, but in the...
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Polycyclic Aromatic Hydrocarbons in the Great Lakes
Polycyclic aromatic hydrocarbons (PAHs) are produced during the incomplete combustion of organic material. They can also be produced through...
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Auxin Transport and Recycling of PIN Proteins in Plants
Polar transport of the phytohormone auxin is mediated by plasma-membrane and endosome localized carrier proteins. PIN proteins are the best...
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Environmental Design Considerationsfor Somatic Embryogenesis
In addition to the biomolecular, physiological, and biochemical aspects of somatic embryogenesis, careful design of environmental conditions is...
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Origin, Development and Structure of Somatic Embryosin Selected Bulbous Ornamentals: BAP as Inducer
Somatic embryogenesis in three important ornamentals is discussed in this chapter. Direct somatic embryo development on the explant tissues...
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Differential Gene Expression During Somatic Embryogenesis
Somatic embryogenesis is a complex developmental program in which somatic cells are induced for a commitment towards forming totipotent...
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Embryogenesis in Catharanthus roseus: Roles of Some External Factors in Proliferation, Maturation and Germination of Embryos
Catharanthus roseus is an important medicinal plant that contains two well-known anticancerous alkaloids, vincristine and vinblastine. Cell...
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Screening and Analysis of Pollen Tube Mutations
Although the cytology of the cellular aspects of male gametophytic development has been very well described for several species, molecular...
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Participation of Plant Hormones in Determination and Progression of Somatic Embryogenesis
In vitro culture protocols have been developed for many species, mainly using empirical approaches, to induce somatic embryogenesis from various...
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Pesticides in the Great Lakes
Pesticides have been widely and heavily used in agriculture in the Great Lakes Basin (approximately 93000 tons were used in 1995 alone). Herbicides...
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Polychlorinated Biphenyls in the Great Lakes
This chapter reviews the scientific understanding of the concentrations, trends, and cycling of polychlorinated biphenyls (PCBs) in the Great...
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Rab GTPases in Plant Endocytosis
The Rab family is part of the Ras superfamily of small GTPases. In eukaryotes Rab GTPases are present as members of gene families, and the...
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Why Somatic Plant Cells Start to form Embryos?
Embryogenesis in plants is not restricted to the fertilized egg cell but can be naturally or artificially induced in many different cell types,...
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Somatic and Zygotic Embryogenesis in Avocado
Avocado is a species widely cultivated for its highly nutritious fruit. Currently, soil-borne diseases such as Phytophthora root rot are severe...
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Protein Markers for Somatic Embryogenesis
The capacity for somatic embryogenesis is a remarkable property of plant cells. Somatic embryogenesis is the process by which somatic cells...
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MDR/PGP Auxin Transport Proteins and Endocytic Cycling
Auxin is an essential regulator of plant growth and development. Polarized transport of auxin is responsible for apical dominance, tropic growth,...
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Somatic Embryogenesis in Genera Medicago: an Overview
This chapter outlines the details of somatic embryogenesis in genera Medicago. Various factors that influence the process of somatic embryo...