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1. Lessons from the physiological role of guanosine in neurodegeneration and cancer: Toward a multimodal mechanism of action?

   Neurodegenerative diseases and brain tumours represent important health challenges due to their severe nature and debilitating consequences that...

   Carla Inês Tasca, Mariachiara Zuccarini, ... Francisco Ciruela in Purinergic Signalling

   Article 15 July 2024
   

2. Detection and characterization of autoreactive memory stem T-cells in children with acute immune thrombocytopenia

   Primary immune thrombocytopenia (ITP) is an acquired autoimmune disorder characterized by an isolated decrease in platelets below 100 × 10 ⁹ /l after...

   Asmaa M. Zahran, Omnia H. El-Badawy, ... Khalid I. Elsayh in Clinical and Experimental Medicine

   Article Open access 15 July 2024
   

3. Mavorixafor: First Approval

   Mavorixafor (XOLREMDI™) is an oral, selective C-X-C chemokine receptor 4 (CXCR4) antagonist developed by X4 Pharmaceuticals that blocks the binding...

   Sheridan M. Hoy in Drugs

   Article 15 July 2024
   

4. Evaluating [²²⁵Ac]Ac-FAPI-46 for the treatment of soft-tissue sarcoma in mice

   Purpose

   Fibroblast Activation Protein (FAP) is an emerging theranostic target that is highly expressed on cancer-associated fibroblasts and on certain...

   Marco F. Taddio, Suraj Doshi, ... Christine E. Mona in European Journal of Nuclear Medicine and Molecular Imaging

   Article Open access 15 July 2024
   

5. Efficacy and Safety of Salvage-line Nivolumab Monotherapy for Advanced Esophageal Squamous Cell Carcinoma: Comparison of 240 mg Versus 480 mg Doses

   Background

   Nivolumab monotherapy is the standard second-line treatment for advanced esophageal squamous cell carcinoma (ESCC) after failure of...

   Yuko Murashima, Shun Yamamoto, ... Ken Kato in Journal of Gastrointestinal Cancer

   Article Open access 15 July 2024
   

6. Disclosing tumor biology by means of molecular imaging in a patient with malignant melanoma and chronic lymphatic leukemia

   Alexander Gäble, Johanna S. Enke, ... Malte Kircher in European Journal of Nuclear Medicine and Molecular Imaging

   Article Open access 15 July 2024
   

7. Effect of dorsal capsular imbrication on intraoperative DRUJ instability following arthroscopic TFCC repair surgery

   Background

   To assess the clinical outcomes and identify the ideal indication for implementing dorsal distal radioulnar joint (DRUJ) capsular...

   Chen-Wei Yeh, Cheng-En Hsu, ... Yung-Cheng Chiu in BMC Musculoskeletal Disorders

   Article Open access 15 July 2024
   

8. DAP12 interacts with RER1 and is retained in the secretory pathway before assembly with TREM2

   DNAX-activating protein of 12 kDa (DAP12) is a transmembrane adapter protein expressed in lymphoid and myeloid lineage cells. It interacts with...

   Yanxia Liu, Sandra Theil, ... Jochen Walter in Cellular and Molecular Life Sciences

   Article Open access 15 July 2024
   

9. TOTEM: a multi-cancer detection and localization approach using circulating tumor DNA methylation markers

   Background

   Detection of cancer and identification of tumor origin at an early stage improve the survival and prognosis of patients. Herein, we...

   Dalin **ong, Tiancheng Han, ... Chunguang Li in BMC Cancer

   Article Open access 15 July 2024
   

10. Evaluation of the clinical efficacy of using an inverted triangular cannulated compression screw in combination with positive or negative buttress reduction for the healing of femoral neck fractures

    Objective

    We aimed to compare the clinical efficacy of inverted triangular cannulated compression screws combined with Gotfried positive or negative...

    Gang Wang, Cui Tang, ... Gaokai Li in BMC Musculoskeletal Disorders

    Article Open access 15 July 2024
    

11. SNCA is a potential therapeutic target for COVID-19 infection in diffuse large B-cell lymphoma patients

    Cuprotosis related genes (CRGs) have been proved to be potential therapeutic targets for coronavirus disease 2019 (COVID-19) and cancer, but their...

    Can Chen, Yun Li, ... Shenxian Qian in Apoptosis

    Article Open access 15 July 2024
    

12. Interrelationship between thyroid hormones and reduced renal function, a review article

    Background

    Understanding the relationship of thyroid hormones with the development of chronic kidney disease (CKD) has important clinical implications...

    Sadaf Agahi, Atieh Amouzegar, ... Ladan Mehran in Thyroid Research

    Article Open access 15 July 2024

13. SHR-A1811 (antibody-drug conjugate) in advanced HER2-mutant non-small cell lung cancer: a multicenter, open-label, phase 1/2 study

    A dose-escalation and expansion, phase 1/2 study (ClinicalTrials.gov, NCT04818333) was conducted to assess the novel antibody-drug conjugate...

    Ziming Li, Zhengbo Song, ... Shun Lu in Signal Transduction and Targeted Therapy

    Article Open access 15 July 2024
    

14. Map** alternative splicing events in colorectal cancer

    Although aberrant splicing events of genes are closely related to the development and progression of colorectal cancer (CRC), the map** of abnormal...

    Yifeng Zheng, Guoqiang Zhong, ... Mingsong Li in Discover Oncology

    Article Open access 15 July 2024
    

15. A Ratiometric Benzimidazole-Based Fluorescent Probe for The Recognition of Phosgene in Solution and Gaseous Phases

    Considering the high toxicity and widespread application of phosgene, there is an urgent need to develop a simple and sensitive method for detecting...

    Pandong Mao, Yufei Song, ... Yuan Wang in Journal of Fluorescence

    Article 15 July 2024
    

16. Assessing the suitability of video-assisted anal fistula treatment for obese patients compared to conventional surgery: a question worth investigating

    Background and aims

    Video-assisted anal fistula treatment (VAAFT) is an innovative surgical approach enabling the direct visualization of the fistula...

    **ao-Li Tang, Zi-Yang Xu, ... **g Yao in International Journal of Colorectal Disease

    Article Open access 15 July 2024

17. Autoantibodies Neutralizing GM-CSF in HIV-Negative Colombian Patients Infected with Cryptococcus gattii and C. neoformans

    Background

    Cryptococcosis is a life-threatening disease caused by Cryptococcus neoformans or C. gattii . Neutralizing autoantibodies (auto-Abs)...

    Carlos A. Arango-Franco, Julian Rojas, ... Andrés A. Arias in Journal of Clinical Immunology

    Article Open access 15 July 2024
    

18. Nonadherence to oral cancer chemotherapy in hepatocellular carcinoma: prevalence and predictive factors in Vietnam

    Purpose

    Standard oral cancer chemotherapy (OCT) or targeted therapy (OTT) has expanded the treatment methods for hepatocellular carcinoma (HCC)....

    Thai Doan Ky, Nguyen Thi Loan, ... Mai Thanh Binh in BMC Cancer

    Article Open access 15 July 2024
    

19. Association of cord blood Ang-1 and sCD105 levels with bronchopulmonary dysplasia in preterm infants

    Background

    To investigate the relationship between cord blood levels of Angiopoietin-1 (Ang-1) and S-endoglin (sCD105) and bronchopulmonary dysplasia...

    **gyun Yang, Yun Wang, ... Lizhen Wang in BMC Pediatrics

    Article Open access 15 July 2024
    

20. Pharmacodynamic Comparison of Two Aspirin Formulations in the Caribbean: The ARC Study

    Introduction

    This prospective, single-arm, crossover pharmacodynamic study assessed the effect of Bayer ^® low-dose enteric-coated aspirin 81 mg...

    Naveen Seecheran, Penelope McCallum, ... Sherry Sandy in Cardiology and Therapy

    Article Open access 15 July 2024