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  1. Interrelationship between thyroid hormones and reduced renal function, a review article

    Background

    Understanding the relationship of thyroid hormones with the development of chronic kidney disease (CKD) has important clinical implications...

    Sadaf Agahi, Atieh Amouzegar, ... Ladan Mehran in Thyroid Research
    Article Open access 15 July 2024

  2. SHR-A1811 (antibody-drug conjugate) in advanced HER2-mutant non-small cell lung cancer: a multicenter, open-label, phase 1/2 study

    A dose-escalation and expansion, phase 1/2 study (ClinicalTrials.gov, NCT04818333) was conducted to assess the novel antibody-drug conjugate...

    Ziming Li, Zhengbo Song, ... Shun Lu in Signal Transduction and Targeted Therapy
    Article Open access 15 July 2024

  3. Map** alternative splicing events in colorectal cancer

    Although aberrant splicing events of genes are closely related to the development and progression of colorectal cancer (CRC), the map** of abnormal...

    Yifeng Zheng, Guoqiang Zhong, ... Mingsong Li in Discover Oncology
    Article Open access 15 July 2024

  4. Lessons from the physiological role of guanosine in neurodegeneration and cancer: Toward a multimodal mechanism of action?

    Neurodegenerative diseases and brain tumours represent important health challenges due to their severe nature and debilitating consequences that...

    Carla Inês Tasca, Mariachiara Zuccarini, ... Francisco Ciruela in Purinergic Signalling
    Article 15 July 2024

  5. Detection and characterization of autoreactive memory stem T-cells in children with acute immune thrombocytopenia

    Primary immune thrombocytopenia (ITP) is an acquired autoimmune disorder characterized by an isolated decrease in platelets below 100 × 10 9 /l after...

    Asmaa M. Zahran, Omnia H. El-Badawy, ... Khalid I. Elsayh in Clinical and Experimental Medicine
    Article Open access 15 July 2024

  6. Efficacy and Safety of Salvage-line Nivolumab Monotherapy for Advanced Esophageal Squamous Cell Carcinoma: Comparison of 240 mg Versus 480 mg Doses

    Background

    Nivolumab monotherapy is the standard second-line treatment for advanced esophageal squamous cell carcinoma (ESCC) after failure of...

    Yuko Murashima, Shun Yamamoto, ... Ken Kato in Journal of Gastrointestinal Cancer
    Article Open access 15 July 2024

  7. Evaluating [225Ac]Ac-FAPI-46 for the treatment of soft-tissue sarcoma in mice

    Purpose

    Fibroblast Activation Protein (FAP) is an emerging theranostic target that is highly expressed on cancer-associated fibroblasts and on certain...

    Marco F. Taddio, Suraj Doshi, ... Christine E. Mona in European Journal of Nuclear Medicine and Molecular Imaging
    Article Open access 15 July 2024

  9. DAP12 interacts with RER1 and is retained in the secretory pathway before assembly with TREM2

    DNAX-activating protein of 12 kDa (DAP12) is a transmembrane adapter protein expressed in lymphoid and myeloid lineage cells. It interacts with...

    Yanxia Liu, Sandra Theil, ... Jochen Walter in Cellular and Molecular Life Sciences
    Article Open access 15 July 2024

  10. TOTEM: a multi-cancer detection and localization approach using circulating tumor DNA methylation markers

    Background

    Detection of cancer and identification of tumor origin at an early stage improve the survival and prognosis of patients. Herein, we...

    Dalin **ong, Tiancheng Han, ... Chunguang Li in BMC Cancer
    Article Open access 15 July 2024

  11. SNCA is a potential therapeutic target for COVID-19 infection in diffuse large B-cell lymphoma patients

    Cuprotosis related genes (CRGs) have been proved to be potential therapeutic targets for coronavirus disease 2019 (COVID-19) and cancer, but their...

    Can Chen, Yun Li, ... Shenxian Qian in Apoptosis
    Article Open access 15 July 2024

  12. A Ratiometric Benzimidazole-Based Fluorescent Probe for The Recognition of Phosgene in Solution and Gaseous Phases

    Considering the high toxicity and widespread application of phosgene, there is an urgent need to develop a simple and sensitive method for detecting...

    Pandong Mao, Yufei Song, ... Yuan Wang in Journal of Fluorescence
    Article 15 July 2024

  13. Checkpoint and Coordinated Cellular Responses to DNA Damage

    The DNA damage and replication checkpoints are signaling mechanisms that regulate and coordinate cellular responses to genotoxic conditions. The...
    **aohong H. Yang, Lee Zou in Cell Cycle Regulation
    Chapter

  14. Regulation of S Phase

    Regulation of DNA replication is critical for accurate and timely dissemination of genomic material to daughter cells. The cell uses a variety of...
    Jamie K. Teer, Anindya Dutta in Cell Cycle Regulation
    Chapter

  15. Control of Cell Proliferation and Growth by Myc Proteins

    Myc proteins act as signal transducers that alter cell proliferation in dependence on signals from the extracellular environment. In normal cells,...
    Sandra Bernard, Martin Eilers in Cell Cycle Regulation
    Chapter

  16. The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis

    Since its discovery in 1986, as the first tumor suppressor gene, the retinoblastoma gene (Rb) has been extensively studied. Numerous biochemical and...
    Jan-Hermen Dannenberg, Hein P. J. te Riele in Cell Cycle Regulation
    Chapter

  17. Senescence and Cell Cycle Control

    In response to various stresses, such as telomere shortening during continuous proliferation, oxidative stress, DNA damage and aberrant oncogene...
    Hiroaki Kiyokawa in Cell Cycle Regulation
    Chapter

  19. ACTH-producing adrenocortical carcinoma: an exceedingly rare diagnosis

    Background

    Adrenocortical carcinoma is a very rare endocrinopathy that has a poor prognosis and is frequently associated with ACTH-independent...

    Miguel Saraiva, Raquel da Inez Correia, ... Isabel Palma in Journal of the Egyptian National Cancer Institute
    Article Open access 15 July 2024

  20. Sex ratio at birth across 100 years in Sweden and risk of cardiovascular disease and all-cause mortality – a national register study

    The human sex ratio at birth (SRB) undergoes temporary changes around a mean proportion of 0.51 male births. SRB has been well studied for...

    Peter M. Nilsson, Kristina Sundquist, ... **njun Li in European Journal of Epidemiology
    Article Open access 15 July 2024
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