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Biosynthesis and function of 1-methyladenosine in transfer RNA
Determining the function of single nucleotide modifications in tRNA has been elusive because so many tRNA modification enzymes are not essential for... -
Transfer RNA modifications and modifying enzymes in Saccharomyces cerevisiae
Transfer RNAs are adaptor molecules, which decode mRNA into protein and, thereby, play a central role in gene expression. During the maturation of a... -
The biosynthesis and functional roles of methylated nucleosides in eukaryotic mRNA
Modified nucleosides are present in mRNA of all eukaryotes, albeit at much lower levels than in other RNA moieties such as rRNA, tRNA, and snRNA.... -
Adenosine to inosine RNA editing in animal cells
Major advances in the understanding of adenosine deaminases acting on RNA (ADARs) have come from the generation of ADAR mutant animals. In mice,... -
Conserved ribosomal RNA modification and their putative roles in ribosome biogenesis and translation
rRNA maturation requires extensive covalent modifications of riboses and bases. These modifications concern exclusively the most conserved regions of... -
Biosynthesis and function of tRNA wobble modifications
Post-transcriptional modifications at the first (wobble) position of the tRNA anticodon participate in the precise decoding of the genetic code that... -
Mechanisms and functions of RNA-guided RNA modification
RNA-guided 2’-O-methylations and pseudouridylations occur in several different types of RNAs and in a wide range of organisms. Hundreds of the RNAs... -
Role of the 5’-cap in the biogenesis of spliceosomal snRNPs
The biogenesis of spliceosomal UsnRNPs in higher eukaryotes involves a nucleocytoplasmic shuttling cycle. After transcription and processing in the... -
Um34 in selenocysteine tRNA is required for the expression of stress-related selenoproteins in mammals
Selenium is an essential micronutrient in the diet of mammals and has many health benefits. Selenium-containing proteins are responsible for most, if... -
Translational Recoding and RNA Modifications
During protein synthesis, codons in mRNA are translated sequentially in frame on the ribosome following strict decoding rules. This process is... -
Modification and editing of RNA: historical overview and important facts to remember
RNA plays a central role in many cellular processes and several peculiarities of RNAs are probably relics of an ancient primordial RNA World. To... -
Role of a conserved pseudouridine in U2 snRNA on the structural and electrostatic features of the spliceosomal pre-mRNA branch site
A pseudouridine (ψ) residue in a phylogenetically conserved position of U2 snRNA that pairs with the intron to form the pre-mRNA branch site helix of... -
Mammalian C to U editing
The sequencing of genomes from higher organisms demonstrated that the number and complexity of expressed mRNA sequences and proteins exceeds the... -
Transfer RNA modifications and DNA editing in HIV-1 reverse transcription
Reverse transcription is a central step in HIV-1 replication that represents a typical case of interplay between viral and cellular factors. HIV-1... -
Nucleotide methylations in rRNA that confer resistance to ribosome-targeting antibiotics
Methylation of rRNA nucleotides is an effective means of conferring resistance to antibiotics that target the bacterial ribosome. This type of... -
Editing and modification in trypanosomatids: the resha** of non-coding RNAs
Trypanosomatids include a number of protozoan parasites that infect over 27 million people worldwide. Besides their medical importance, these... -
Deep migration learning-based recognition of diseases and insect pests in Yunnan tea under complex environments
BackgroundThe occurrence, development, and outbreak of tea diseases and pests pose a significant challenge to the quality and yield of tea,...
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Molecular Characterization of Lineage-IV Peste Des Petits Ruminants Virus and the Development of In-House Indirect Enzyme-Linked Immunosorbent Assay (IELISA) for its Rapid Detection”
Peste des petits ruminants (PPRV), a highly contagious viral disease, causes significant economic losses concerning sheep and goats. Recently, PPR...
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EAF2 Downregulation Recruits Tumor-associated Macrophages in Prostate Cancer through Upregulation of MIF
BackgroundThe role of tumor inflammatory microenvironment in the advancement of cancer, particularly prostate cancer, is widely acknowledged....