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Dual electrical stimulation at spinal-muscular interface reconstructs spinal sensorimotor circuits after spinal cord injury
The neural signals produced by varying electrical stimulation parameters lead to characteristic neural circuit responses. However, the...
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CHIT1-positive microglia drive motor neuron ageing in the primate spinal cord
Ageing is a critical factor in spinal-cord-associated disorders
1 , yet the ageing-specific mechanisms underlying this relationship remain poorly...
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Early decompression promotes motor recovery after cervical spinal cord injury in rats with chronic cervical spinal cord compression
The number of elderly patients with spinal cord injury without radiographic abnormalities (SCIWORA) has been increasing in recent years and common of...
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Return to work after traumatic spinal fractures and spinal cord injuries: a retrospective cohort study
This study aimed to determine the factors associated with return to work (RTW) after traumatic spinal fracture and spinal cord injury. It provided a...
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Porous microneedle patch with sustained delivery of extracellular vesicles mitigates severe spinal cord injury
The transplantation of mesenchymal stem cells-derived secretome, particularly extracellular vesicles is a promising therapy to suppress spinal cord...
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Spinal cord tethering and syringomyelia after trauma: impact of age and surgical outcome
Posttraumatic spinal cord tethering and syringomyelia frequently lead to progressive neurological loss. Although several studies demonstrated...
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Walking naturally after spinal cord injury using a brain–spine interface
A spinal cord injury interrupts the communication between the brain and the region of the spinal cord that produces walking, leading to paralysis
1 ,2 ....
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Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer
Unlike adult mammals, zebrafish regenerate spinal cord tissue and recover locomotor ability after a paralyzing injury. Here, we find that ependymal...
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A transcriptome dataset for gonadectomy-induced changes in rat spinal cord
Circulating sex steroid hormones are critical for neural function and development of neuroplasticity in many regions of the central nervous system....
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Functional map** of the lower urinary tract by epidural electrical stimulation of the spinal cord in decerebrated cat model
Several neurologic diseases including spinal cord injury, Parkinson’s disease or multiple sclerosis are accompanied by disturbances of the lower...
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De novo aging-related NADPH diaphorase positive megaloneurites in the sacral spinal cord of aged dogs
We investigated aging-related changes in nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) in the spinal cord of aged dogs. At all...
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Association between functional outcomes and psychological variables in persons with spinal cord injury
We aimed to explore the association of functional outcomes with psychological variables, including depression, anxiety, sleep quality, and suicide...
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Neuroprotective gap-junction-mediated bystander transformations in the adult zebrafish spinal cord after injury
The adult zebrafish spinal cord displays an impressive innate ability to regenerate after traumatic insults, yet the underlying adaptive cellular...
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Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica
Here, we introduce the Tabulae Paralytica —a compilation of four atlases of spinal cord injury (SCI) comprising a single-nucleus transcriptome atlas...
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Prediction of isometric forces from combined epidural spinal cord and neuromuscular electrical stimulation in the rat lower limb
Although epidural spinal cord and muscle stimulation have each been separately used for restoration of movement after spinal cord injury, their...
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Topography of the GLP-1/GLP-1 receptor system in the spinal cord of male mice
Glucagon-like peptide-1 receptor (GLP-1R) agonists are now commonly used to treat type 2 diabetes and obesity. GLP-1R signaling in the spinal cord...
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Pharmacological management of acute spinal cord injury: a longitudinal multi-cohort observational study
Multiple types and classes of medications are administered in the acute management of traumatic spinal cord injury. Prior clinical studies and...
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Pontomedullary junction as a reference for spinal cord cross-sectional area: validation across neck positions
Spinal cord cross-sectional area (CSA) is an important MRI biomarker to assess spinal cord atrophy in various neurodegenerative and traumatic spinal...
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Assessment of spinal cord injury using ultrasound elastography in a rabbit model in vivo
The effect of the mechanical micro-environment on spinal cord injury (SCI) and treatment effectiveness remains unclear. Currently, there are limited...
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Inhibiting spinal cord-specific hsp90 isoforms reveals a novel strategy to improve the therapeutic index of opioid treatment
Opioids are the gold standard for the treatment of chronic pain but are limited by adverse side effects. In our earlier work, we showed that Heat...
