Search
Search Results
-
Cytotoxicity and genotoxicity of bioceramic root canal sealers compared to conventional resin-based sealer
The aim of this study was to evaluate cytotoxicity and genotoxicity of calcium-silicate based sealers and comparing them with a gold standard—an...
-
Cell-mediated cytotoxicity within CSF and brain parenchyma in spinal muscular atrophy unaltered by nusinersen treatment
5q-associated spinal muscular atrophy (SMA) is a motoneuron disease caused by mutations in the survival motor neuron 1 (SMN1) gene. Adaptive immunity...
-
The potential of phenothiazinium dyes as cytotoxicity markers in cisplatin-treated cells
Assessing the in vitro toxicity of compounds on cell cultures is an important step during the screening of candidate molecules for diverse...
-
Inter-continental variability in the relationship of oxidative potential and cytotoxicity with PM2.5 mass
Most fine ambient particulate matter (PM 2.5 )-based epidemiological models use globalized concentration-response (CR) functions assuming that the...
-
Bystander activated CD8+ T cells mediate neuropathology during viral infection via antigen-independent cytotoxicity
Although many viral infections are linked to the development of neurological disorders, the mechanism governing virus-induced neuropathology remains...
-
Variation in pentose phosphate pathway-associated metabolism dictates cytotoxicity outcomes determined by tetrazolium reduction assays
Tetrazolium reduction and resazurin assays are the mainstay of routine in vitro toxicity batteries. However, potentially erroneous characterization...
-
Copper pyrithione and zinc pyrithione induce cytotoxicity and neurotoxicity in neuronal/astrocytic co-cultured cells via oxidative stress
Previous studies on copper pyrithione (CPT) and zinc pyrithione (ZPT) as antifouling agents have mainly focused on marine organisms. Even though CPT...
-
Apolipoprotein L1 (APOL1) renal risk variant-mediated podocyte cytotoxicity depends on African haplotype and surface expression
Homozygous Apolipoprotein L1 (APOL1) variants G1 and G2 cause APOL1-mediated kidney disease, purportedly acting as surface cation channels in...
-
Cytotoxicity, mutagenicity and genotoxicity of electronic cigarettes emission aerosols compared to cigarette smoke: the REPLICA project
Concerns have recently increased that the integrity of some scientific research is questionable due to the inability to reproduce the claimed results...
-
Nanofibrous materials affect the reaction of cytotoxicity assays
Nanofibrous materials are widely investigated as a replacement for the extracellular matrix, the 3D foundation for cells in all tissues. However, as...
-
Functional non-parametric mixed effects models for cytotoxicity assessment and clustering
A multitude of natural and synthetic chemicals are present in our environment.Through the study of a compound’s cytotoxicity, researchers can...
-
CD46 protects the bladder cancer cells from cetuximab-mediated cytotoxicity
Epidermal growth factor receptor (EGFR) is an effective target for those patients with metastatic colorectal cancers that retain the wild-type RAS ...
-
Semisynthesis of 5-O-ester derivatives of renieramycin T and their cytotoxicity against non-small-cell lung cancer cell lines
The semisynthesis of 5- O -ester derivatives of renieramycin T was accomplished through the photoredox reaction of renieramycin M ( 1 ), a...
-
G9a/GLP inhibition during ex vivo lymphocyte expansion increases in vivo cytotoxicity of engineered T cells against hepatocellular carcinoma
Engineered T cells transiently expressing tumor-targeting receptors are an attractive form of engineered T cell therapy as they carry no risk of...
-
An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity
Human epidermal growth factor receptor 2 (HER2) is a receptor tyrosine kinase that plays an oncogenic role in breast, gastric and other solid tumors....
-
Peripheral T cell cytotoxicity predicts the efficacy of anti-PD-1 therapy for advanced non-small cell lung cancer patients
Anti-programmed cell death-1 (PD-1) therapy exerts beneficial effects in a limited population of cancer patients. Therefore, more accurate...
-
The chemical profiles and cytotoxicity of gaharu bouya oil from Borneo’s Gonystylus bancanus wood
Gaharu bouya oil obtained from distillation of the woods from Gonystylus genus has attracted essential oil industry interest. However, the...
-
Drug cytotoxicity screening using human intestinal organoids propagated with extensive cost-reduction strategies
Organoids are regarded as physiologically relevant cell models and useful for compound screening for drug development; however, their applications...
-
Development of a bispecific antibody targeting PD-L1 and TIGIT with optimal cytotoxicity
Programmed death-ligand 1 (PD-L1) and T cell immunoreceptor with Ig and ITIM domains (TIGIT) are two potential targets for cancer immunotherapy,...
-
Hemipiperazines as peptide-derived molecular photoswitches with low-nanomolar cytotoxicity
Molecular photoswitches transform light energy into reversible structural changes. Their combination with known pharmacophores often allows for...
