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Reciprocal modulation of ammonia and melanin production has implications for cryptococcal virulence
The fungus Cryptococcus neoformans is the causative agent of cryptococcosis, a disease that is uniformly lethal unless treated with antifungal drugs,...
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Decomposing virulence to understand bacterial clearance in persistent infections
Following an infection, hosts cannot always clear the pathogen, instead either dying or surviving with a persistent infection. Such variation is...
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Metabolism of l-arabinose converges with virulence regulation to promote enteric pathogen fitness
Virulence and metabolism are often interlinked to control the expression of essential colonisation factors in response to host-associated signals....
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Targeting bacterial nickel transport with aspergillomarasmine A suppresses virulence-associated Ni-dependent enzymes
Microbial Ni 2+ homeostasis underpins the virulence of several clinical pathogens. Ni 2+ is an essential cofactor in urease and [NiFe]-hydrogenases...
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Antimicrobial resistance and virulence of subgingival staphylococci isolated from periodontal health and diseases
The dysbiotic biofilm of periodontitis may function as a reservoir for opportunistic human pathogens of clinical relevance. This study explored the...
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Molecular and virulence characteristics of carbapenem-resistant Acinetobacter baumannii isolates: a prospective cohort study
This study aimed to characterize the molecular features and virulence profiles of carbapenem-resistant Acinetobacter baumannii (CRAB) isolates....
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LOV1 protein of Pseudomonas cichorii JBC1 modulates its virulence and lifestyles in response to blue light
Bacteria perceive light signals via photoreceptors and modulate many physiological and genetic processes. The impacts played by light, oxygen, or...
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Modulation of MRSA virulence gene expression by the wall teichoic acid enzyme TarO
Phenol-soluble modulins (PSMs) and Staphylococcal protein A (SpA) are key virulence determinants for community-associated methicillin-resistant Staphyl...
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Epistatic interactions between the high pathogenicity island and other iron uptake systems shape Escherichia coli extra-intestinal virulence
The intrinsic virulence of extra-intestinal pathogenic Escherichia coli is associated with numerous chromosomal and/or plasmid-borne genes, encoding...
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Klebsiella pneumoniae clinical isolates with features of both multidrug-resistance and hypervirulence have unexpectedly low virulence
Klebsiella pneumoniae has been classified into two types, classical K. pneumoniae (cKP) and hypervirulent K. pneumoniae (hvKP). cKP isolates are...
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Characterization of resistance and virulence factors in livestock-associated methicillin-resistant Staphylococcus aureus
The study investigated the economic concerns associated with livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) in livestock...
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Exploring the virulence potential of Staphylococcus aureus CC121 and CC152 lineages related to paediatric community-acquired bacteraemia in Manhiça, Mozambique
Staphylococcus aureus is a frequent agent of bacteraemia. This bacterium has a variety of virulence traits that allow the establishment and...
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TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence
Viruses, as opportunistic intracellular parasites, hijack the cellular machinery of host cells to support their survival and propagation. Numerous...
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Diffusible signal factors (DSFs) bind and repress VirF, the leading virulence activator of Shigella flexneri
Shigella , the aetiological agent of human bacillary dysentery, controls the expression of its virulence determinants through an environmentally...
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Species prevalence, virulence genes, and antibiotic resistance of enterococci from food-producing animals at a slaughterhouse in Turkey
Healthy cattle, sheep, and goats can be reservoirs for gastrointestinal pathogenic fecal enterococci, some of which could be multidrug-resistant to...
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Ustilago maydis PR-1-like protein has evolved two distinct domains for dual virulence activities
The diversification of effector function, driven by a co-evolutionary arms race, enables pathogens to establish compatible interactions with hosts....
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Differentiated extracts from freshwater and terrestrial mollusks inhibit virulence factor production in Cryptococcus neoformans
The human fungal pathogen, Cryptococcus neoformans , is responsible for deadly infections among immunocompromised individuals with the evolution of...
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Virulence and resistance profiling of Staphylococcus aureus isolated from subclinical bovine mastitis in the Pakistani Pothohar region
Mastitis is considered one of the most widespread infectious disease of cattle and buffaloes, affecting dairy herds. The current study aimed to...
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The virulence regulator VirB from Shigella flexneri uses a CTP-dependent switch mechanism to activate gene expression
The transcriptional antisilencer VirB acts as a master regulator of virulence gene expression in the human pathogen Shigella flexneri . It binds DNA...
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Limited impact of bacterial virulence on early mortality risk factors in Acinetobacter baumannii bacteremia observed in a Galleria mellonella model
Acinetobacter baumannii (AB) has emerged as a major pathogen in vulnerable and severely ill patients. It remains unclear whether early mortality (EM)...
