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Repeated passive visual experience modulates spontaneous and non-familiar stimuli-evoked neural activity
Familiarity creates subjective memory of repeated innocuous experiences, reduces neural and behavioral responsiveness to those experiences, and...
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Spontaneous persistent activity and inactivity in vivo reveals differential cortico-entorhinal functional connectivity
Understanding the functional connectivity between brain regions and its emergent dynamics is a central challenge. Here we present a theory-experiment...
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A synaptic corollary discharge signal suppresses midbrain visual processing during saccade-like locomotion
In motor control, the brain not only sends motor commands to the periphery, but also generates concurrent internal signals known as corollary...
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Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer’s disease
Calcium dynamics in astrocytes represent a fundamental signal that through gliotransmitter release regulates synaptic plasticity and behaviour. Here...
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Analog neuromorphic circuit for spontaneous Ca2+ oscillations
This study proposes an innovative analog neuromorphic circuit design to mimic spontaneous Ca 2+ oscillations observed in astrocytes. Unlike...
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Repetitive nociceptive stimulation increases spontaneous neural activation similar to nociception-induced activity in mouse insular cortex
Recent noninvasive neuroimaging technology has revealed that spatiotemporal patterns of cortical spontaneous activity observed in chronic pain...
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Synaptic mechanisms for associative learning in the cerebellar nuclei
Associative learning during delay eyeblink conditioning (EBC) depends on an intact cerebellum. However, the relative contribution of changes in the...
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CA3 hippocampal synaptic plasticity supports ripple physiology during memory consolidation
The consolidation of recent memories depends on memory replays, also called ripples, generated within the hippocampus during slow-wave sleep, and...
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Intrinsic and synaptic determinants of receptive field plasticity in Purkinje cells of the mouse cerebellum
Non-synaptic (intrinsic) plasticity of membrane excitability contributes to aspects of memory formation, but it remains unclear whether it merely...
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Noradrenaline depresses facial stimulation-evoked cerebellar MLI-PC synaptic transmission via α2-AR/PKA signaling cascade in vivo in mice
The noradrenergic fibers of the locus coeruleus, together with mossy fibers and climbing fibers, comprise the three types of cerebellar afferents...
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Self-organization of modular activity in immature cortical networks
During development, cortical activity is organized into distributed modular patterns that are a precursor of the mature columnar functional...
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Homeostatic synaptic plasticity rescues neural coding reliability
To survive, animals must recognize reoccurring stimuli. This necessitates a reliable stimulus representation by the neural code. While synaptic...
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NPY-mediated synaptic plasticity in the extended amygdala prioritizes feeding during starvation
Efficient control of feeding behavior requires the coordinated adjustment of complex motivational and affective neurocircuits. Neuropeptides from...
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mGluR5 is transiently confined in perisynaptic nanodomains to shape synaptic function
The unique perisynaptic distribution of postsynaptic metabotropic glutamate receptors (mGluRs) at excitatory synapses is predicted to directly shape...
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LPS induces microglial activation and GABAergic synaptic deficits in the hippocampus accompanied by prolonged cognitive impairment
Neuroinflammation impacts the brain and cognitive behavior through microglial activation. In this study, we determined the temporal sequence from...
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Structural determinants and regulation of spontaneous activity in GABAA receptors
GABA A receptors are vital for controlling neuronal excitability and can display significant levels of constitutive activity that contributes to tonic...
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Exposure to an enriched environment modulates the synaptic vesicle cycle in a mouse spinal cord injury model
Spinal cord injury (SCI) leads to motor and sensory impairment below the site of injury, thereby necessitating rehabilitation. An enriched...
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Tomosyns attenuate SNARE assembly and synaptic depression by binding to VAMP2-containing template complexes
Tomosyns are widely thought to attenuate membrane fusion by competing with synaptobrevin-2/VAMP2 for SNARE-complex assembly. Here, we present...
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Synaptic architecture of leg and wing premotor control networks in Drosophila
Animal movement is controlled by motor neurons (MNs), which project out of the central nervous system to activate muscles
1 . MN activity is...
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Loss of dysbindin-1 in excitatory neurons in mice impacts NMDAR-dependent behaviors, neuronal morphology and synaptic transmission in the ventral hippocampus
Dysbindin-1, a protein encoded by the schizophrenia susceptibility gene DTNBP1 , is reduced in the hippocampus of schizophrenia patients. It is...
