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Phosphorylation of the PA subunit of influenza polymerase at Y393 prevents binding of the 5′-termini of RNA and polymerase function
The influenza A virus (IAV) polymerase is a multifunctional machine that can adopt alternative configurations to perform transcription and...
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Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family
Tilapia Lake Virus (TiLV), a recently discovered pathogen of tilapia fish, belongs to the Amnoonviridae family from the Articulavirales order. Its...
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The ubiquitination landscape of the influenza A virus polymerase
During influenza A virus (IAV) infections, viral proteins are targeted by cellular E3 ligases for modification with ubiquitin. Here, we decipher and...
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Raphe glucose-sensing serotonergic neurons stimulate KNDy neurons to enhance LH pulses via 5HT2CR: rat and goat studies
Dysfunction of central serotonergic neurons is known to cause depressive disorders in humans, who often show reproductive and/or glucose metabolism...
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The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome
The current model is that the influenza virus polymerase (FluPol) binds either to host RNA polymerase II (RNAP II) or to the acidic nuclear...
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Conditional Oprk1-dependent Kiss1 deletion in kisspeptin neurons caused estrogen-dependent LH pulse disruption and LH surge attenuation in female rats
The gonadotropin-releasing hormone (GnRH) pulse and surge are considered to be generated by arcuate kisspeptin/neurokinin B/dynorphin A (KNDy)...
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An Influenza A virus can evolve to use human ANP32E through altering polymerase dimerization
Human ANP32A and ANP32B are essential but redundant host factors for influenza virus genome replication. While most influenza viruses cannot...
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A CpG island-encoded mechanism protects genes from premature transcription termination
Transcription must be tightly controlled to regulate gene expression and development. However, our understanding of the molecular mechanisms that...
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Cryo-EM structures of Thogoto virus polymerase reveal unique RNA transcription and replication mechanisms among orthomyxoviruses
Influenza viruses and thogotoviruses account for most recognized orthomyxoviruses. Thogotoviruses, exemplified by Thogoto virus (THOV), are capable...
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Structures of H5N1 influenza polymerase with ANP32B reveal mechanisms of genome replication and host adaptation
Avian influenza A viruses (IAVs) pose a public health threat, as they are capable of triggering pandemics by crossing species barriers. Replication...
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Mutation in Smek2 regulating hepatic glucose metabolism causes hypersarcosinemia and hyperhomocysteinemia in rats
Suppressor of mek1 (Dictyostelium) homolog 2 ( Smek2 ), was identified as one of the responsible genes for diet-induced hypercholesterolemia (DIHC) of...
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Structures of influenza A virus RNA polymerase offer insight into viral genome replication
Influenza A viruses are responsible for seasonal epidemics, and pandemics can arise from the transmission of novel zoonotic influenza A viruses to...
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Spatiotemporal expression of IgLON family members in the develo** mouse nervous system
Differential expression of cell adhesion molecules in neuronal populations is one of the many mechanisms promoting the formation of functional neural...
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Map** inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies
Influenza A viruses cause seasonal epidemics and global pandemics, representing a considerable burden to healthcare systems. Central to the...
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Abundant extrasynaptic expression of α3β4-containing nicotinic acetylcholine receptors in the medial habenula–interpeduncular nucleus pathway in mice
Nicotinic acetylcholine receptors (nAChRs) in the medial habenula (MHb)–interpeduncular nucleus (IPN) pathway play critical roles in nicotine-related...
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BTN3A3 evasion promotes the zoonotic potential of influenza A viruses
Spillover events of avian influenza A viruses (IAVs) to humans could represent the first step in a future pandemic
1 . Several factors that limit the...
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Host ANP32A mediates the assembly of the influenza virus replicase
Aquatic birds represent a vast reservoir from which new pandemic influenza A viruses can emerge
1 . Influenza viruses contain a negative-sense...
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Neuromedin U-deficient rats do not lose body weight or food intake
Studies in genetically modified mice establish that essential roles of endogenous neuromedin U (NMU) are anorexigenic function and metabolic...
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Early parental deprivation during primate infancy has a lifelong impact on gene expression in the male marmoset brain
Adverse early life experiences are well-established risk factors for neurological disorders later in life. However, the molecular mechanisms...
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MicroRNA-141-regulated KLK10 and TNFSF-15 gene expression in hepatoblastoma cells as a novel mechanism in liver carcinogenesis
Liver cancer is one of the most pivotal global health problems, leading hepatocellular carcinoma (HCC) with a significant increase in cases...
