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Immunogenetic losses co-occurred with seahorse male pregnancy and mutation in tlx1 accompanied functional asplenia
In the highly derived syngnathid fishes (pipefishes, seadragons & seahorses), the evolution of sex-role reversed brooding behavior culminated in the...
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Conservation priorities in an endangered estuarine seahorse are informed by demographic history
Historical demographic events shape genetic diversity that remains evident in the genomes of contemporary populations. In the case of species that...
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Genome sequences reveal global dispersal routes and suggest convergent genetic adaptations in seahorse evolution
Seahorses have a circum-global distribution in tropical to temperate coastal waters. Yet, seahorses show many adaptations for a sedentary, cryptic...
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A novel non-invasive efficient photography-based technique for length measuring and individual identification of seahorses
This study aimed to develop a non-invasive and efficient method for measuring and identifying individual seahorses ( Hippocampus patagonicus ) in their...
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High concentrations of Maraviroc do not alter immunological and metabolic parameters of CD4 T cells
Maraviroc (MVC) is an antiretroviral drug capable of binding to CCR5 receptors and block HIV entry into target cells. Moreover, MVC can activate...
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Oxygen consumption rate of Caenorhabditis elegans as a high-throughput endpoint of toxicity testing using the Seahorse XFe96 Extracellular Flux Analyzer
Caenorhabditis elegans presents functioning, biologically relevant phenotypes and is frequently used as a bioindicator of toxicity. However, most C....
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Divergent molecular signatures in fish Bouncer proteins define cross-fertilization boundaries
Molecular compatibility between gametes is a prerequisite for successful fertilization. As long as a sperm and egg can recognize and bind each other...
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Impact of experimental colitis on mitochondrial bioenergetics in intestinal epithelial cells
Intestinal homeostasis is highly dependent on optimal epithelial barrier function and permeability. Intestinal epithelial cells (IEC) regulate these...
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Importance of Per2 in cardiac mitochondrial protection during stress
During myocardial injury, inflammatory mediators and oxidative stress significantly increase to impair cardiac mitochondria. Emerging evidence has...
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LncRNA TUG1 mediates microglial inflammatory activation by regulating glucose metabolic reprogramming
Microglia are natural immune cells in the central nervous system, and the activation of microglia is accompanied by a reprogramming of glucose...
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Morphine-induced modulation of Nrf2-antioxidant response element signaling pathway in primary human brain microvascular endothelial cells
Morphine is one of the most potent opioid analgesic used for pain treatment. Morphine action in the central nervous system requires crossing the...
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Pactacin is a novel digestive enzyme in teleosts
Generally, animals extract nutrients from food by degradation using digestive enzymes. Trypsin and chymotrypsin, one of the major digestive enzymes...
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The paradox of retained genetic diversity of Hippocampus guttulatus in the face of demographic decline
Genetic diversity is the raw foundation for evolutionary potential. When genetic diversity is significantly reduced, the risk of extinction is...
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Iron chelation increases beige fat differentiation and metabolic activity, preventing and treating obesity
Beige and brown fat consume glucose and lipids to produce heat, using uncoupling protein 1 (UCP1). It is thought that full activation of brown...
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l-Carnitine reduces reactive oxygen species/endoplasmic reticulum stress and maintains mitochondrial function during autophagy-mediated cell apoptosis in perfluorooctanesulfonate-treated renal tubular cells
We previously reported that perfluorooctanesulfonate (PFOS) causes autophagy-induced apoptosis in renal tubular cells (RTCs) through a mechanism...
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Structure and activation mechanism of the Makes caterpillars floppy 1 toxin
The bacterial Makes caterpillars floppy 1 (Mcf1) toxin promotes apoptosis in insects, leading to loss of body turgor and death. The molecular...
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Radiation-induced changes in energy metabolism result in mitochondrial dysfunction in salivary glands
Salivary glands are indirectly damaged during radiotherapy for head and neck cancer, resulting in acute and chronic hyposalivation. Current...
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Genetic variation in NDFIP1 modifies the metabolic patterns in immune cells of multiple sclerosis patients
One of the 233 polymorphisms associated with multiple sclerosis (MS) susceptibility lies within the NDFIP1 gene, and it was previously identified as...
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The follicle-stimulating hormone triggers rapid changes in mitochondrial structure and function in porcine cumulus cells
Oocyte maturation is a key process during which the female germ cell undergoes resumption of meiosis and completes its preparation for embryonic...
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Effect of hypoxia factors gene silencing on ROS production and metabolic status of A375 malignant melanoma cells
The innate response of melanocytes to exogenous or endogenous stress stimuli like extreme pH and temperature, metabolite and oxygen deficiency or a...
