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A nanoscale MOF-based heterogeneous catalytic system for the polymerization of N-carboxyanhydrides enables direct routes toward both polypeptides and related hybrid materials
Synthetic polypeptides have emerged as versatile tools in both materials science and biomedical engineering due to their tunable properties and...
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Isolation of nucleic acids using liquid–liquid phase separation of pH-sensitive elastin-like polypeptides
Extraction of nucleic acids (NAs) is critical for many methods in molecular biology and bioanalytical chemistry. NA extraction has been extensively...
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Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis
Although several long noncoding RNAs (lncRNAs) have recently been shown to encode small polypeptides, those in testis remain largely uncharacterized....
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Programmable viscoelasticity in protein-RNA condensates with disordered sticker-spacer polypeptides
Liquid-liquid phase separation of multivalent proteins and RNAs drives the formation of biomolecular condensates that facilitate membrane-free...
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A moisture-tolerant route to unprotected α/β-amino acid N-carboxyanhydrides and facile synthesis of hyperbranched polypeptides
A great hurdle in the production of synthetic polypeptides lies in the access of N -carboxyanhydrides (NCA) monomers, which requires dry solvents,...
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4210 Da and 1866 Da polypeptides as potential biomarkers of liver disease progression in hepatitis B virus patients
HBV infection is recognized as a serious global health problem, and hepatitis B virus infection is a complicated chronic disease leading to liver...
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Ultra-strong bio-glue from genetically engineered polypeptides
The development of biomedical glues is an important, yet challenging task as seemingly mutually exclusive properties need to be combined in one...
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Cryo-EM structure of a Ca2+-bound photosynthetic LH1-RC complex containing multiple αβ-polypeptides
The light-harvesting-reaction center complex (LH1-RC) from the purple phototrophic bacterium Thiorhodovibrio strain 970 exhibits an LH1 absorption...
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Antimicrobial effects of syndiotactic polypeptides
We present design and antibacterial studies of stereochemically diversified antimicrobial peptides against multidrug-resistant bacterial pathogens....
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Modulating pro-adhesive nature of metallic surfaces through a polypeptide coupling via diazonium chemistry
The design of biomaterials able to facilitate cell adhesion is critical in the field of tissue engineering. Precise control of surface chemistry at...
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Intermolecular interactions underlie protein/peptide phase separation irrespective of sequence and structure at crowded milieu
Liquid-liquid phase separation (LLPS) has emerged as a crucial biological phenomenon underlying the sequestration of macromolecules (such as proteins...
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YTHDF2 facilitates aggresome formation via UPF1 in an m6A-independent manner
YTHDF2 has been extensively studied and typified as an RNA-binding protein that specifically recognizes and destabilizes RNAs harboring N 6 -methyladeno...
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Intestinal intermediate filament polypeptides in C. elegans: Common and isotype-specific contributions to intestinal ultrastructure and function
The abundance and diversity of intermediate filaments (IFs) in the C. elegans intestine indicate important contributions to intestinal function and...
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Noncoding translation mitigation
Translation is pervasive outside of canonical coding regions, occurring in long noncoding RNAs, canonical untranslated regions and introns
1 –4 ,...
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Protein degradation by human 20S proteasomes elucidates the interplay between peptide hydrolysis and splicing
If and how proteasomes catalyze not only peptide hydrolysis but also peptide splicing is an open question that has divided the scientific community....
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Rhodobacter capsulatus forms a compact crescent-shaped LH1–RC photocomplex
Rhodobacter ( Rba .) capsulatus has been a favored model for studies of all aspects of bacterial photosynthesis. This purple phototroph contains PufX,...
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Recognition of an Ala-rich C-degron by the E3 ligase Pirh2
The ribosome-associated quality-control (RQC) pathway degrades aberrant nascent polypeptides arising from ribosome stalling during translation. In...
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Remodeling of the ribosomal quality control and integrated stress response by viral ubiquitin deconjugases
The strategies adopted by viruses to reprogram the translation and protein quality control machinery and promote infection are poorly understood....
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Ageing exacerbates ribosome pausing to disrupt cotranslational proteostasis
Ageing is accompanied by a decline in cellular proteostasis, which underlies many age-related protein misfolding diseases
1 ,2 . Yet, how ageing impairs...
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Asymmetric structure of the native Rhodobacter sphaeroides dimeric LH1–RC complex
Rhodobacter sphaeroides is a model organism in bacterial photosynthesis, and its light-harvesting-reaction center (LH1–RC) complex contains both...
