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Precise prediction of phase-separation key residues by machine learning
Understanding intracellular phase separation is crucial for deciphering transcriptional control, cell fate transitions, and disease mechanisms....
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Phase-separation facilitated one-step fabrication of multiscale heterogeneous two-aqueous-phase gel
Engineering heterogeneous hydrogels with distinct phases at various lengths, which resemble biological tissues with high complexity, remains...
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Solutes unmask differences in clustering versus phase separation of FET proteins
Phase separation and percolation contribute to phase transitions of multivalent macromolecules. Contributions of percolation are evident through the...
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Vapor-induced phase-separation-enabled versatile direct ink writing
Versatile printing of polymers, metals, and composites always calls for simple, economic approaches. Here we present an approach to three-dimensional...
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Phase separation of FSP1 promotes ferroptosis
Ferroptosis is evolving as a highly promising approach to combat difficult-to-treat tumour entities including therapy-refractory and...
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Phase separation of protein mixtures is driven by the interplay of homotypic and heterotypic interactions
Prion-like low-complexity domains (PLCDs) are involved in the formation and regulation of distinct biomolecular condensates that form via phase...
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Ambient-conditions spinning of functional soft fibers via engineering molecular chain networks and phase separation
Producing functional soft fibers via existing spinning methods is environmentally and economically costly due to the complexity of spinning...
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Isolation of nucleic acids using liquid–liquid phase separation of pH-sensitive elastin-like polypeptides
Extraction of nucleic acids (NAs) is critical for many methods in molecular biology and bioanalytical chemistry. NA extraction has been extensively...
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Initiation and modulation of Tau protein phase separation by the drug suramin
Tau is an intrinsically disordered neuronal protein in the central nervous system. Aggregated Tau is the main component of neurofibrillary tangles...
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NuMA regulates mitotic spindle assembly, structural dynamics and function via phase separation
A functional mitotic spindle is essential for accurate chromosome congression and segregation during cell proliferation; however, the underlying...
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53BP1 regulates heterochromatin through liquid phase separation
Human 53BP1 is primarily known as a key player in regulating DNA double strand break (DSB) repair choice; however, its involvement in other...
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The first space-filling polyhedrons of polymer cubic cells originated from Weaire-Phelan structure created by polymerization induced phase separation
The Weaire–Phelan structure is a three-dimensional structure composed of two different polyhedra having the same volume, i.e., pyritohedron and...
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Rational design of phase separating peptides based on phase separating protein sequence of p53
Artificial phase-separating (PS) peptides can be used in various applications such as microreactors and drug delivery; however, the design of...
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Rationally designed nanotrap structures for efficient separation of rare earth elements over a single step
Extracting rare earth elements (REEs) from wastewater is essential for the growth and an eco-friendly sustainable economy. However, it is a daunting...
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Subtomographic imaging of a polarisation sensitive phase pattern localised in phase space
A transparent polarisation-sensitive phase pattern changes the phase of transmitted light without absorption, whereas this change of phase depends on...
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Covalent organic framework membranes for efficient separation of monovalent cations
Covalent organic frameworks (COF), with rigid, highly ordered and tunable structures, can actively manipulate the synergy of entropic selectivity and...
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Phase separation of Nur77 mediates celastrol-induced mitophagy by promoting the liquidity of p62/SQSTM1 condensates
Liquid-liquid phase separation promotes the formation of membraneless condensates that mediate diverse cellular functions, including autophagy of...
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Photo-tailored heterocrystalline covalent organic framework membranes for organics separation
Organics separation for purifying and recycling environment-detrimental solvents is essential to sustainable chemical industries. Covalent organic...
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Dual-bionic superwetting gears with liquid directional steering for oil-water separation
Develo** an effective and sustainable method for separating and purifying oily wastewater is a significant challenge. Conventional separation...
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Non-associative phase separation in an evaporating droplet as a model for prebiotic compartmentalization
The synthetic pathways of life’s building blocks are envisaged to be through a series of complex prebiotic reactions and processes. However, the...
