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Spatial transcriptomics reveals molecular dysfunction associated with cortical Lewy pathology
A key hallmark of Parkinson’s disease (PD) is Lewy pathology. Composed of α-synuclein, Lewy pathology is found both in dopaminergic neurons that...
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A whole-slide foundation model for digital pathology from real-world data
Digital pathology poses unique computational challenges, as a standard gigapixel slide may comprise tens of thousands of image tiles
1 –3 . Prior models...
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Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein pathology
Lewy body (LB) diseases, characterized by the aggregation of misfolded α-synuclein proteins, exhibit notable clinical heterogeneity. This may be due...
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The aldehyde dehydrogenase 2 rs671 variant enhances amyloid β pathology
In the ALDH2 rs671 variant, a guanine changes to an adenine, resulting in a dramatic decrease in the catalytic activity of the enzyme....
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Disease-associated astrocyte epigenetic memory promotes CNS pathology
Disease-associated astrocyte subsets contribute to the pathology of neurologic diseases, including multiple sclerosis and experimental autoimmune...
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Regression-based Deep-Learning predicts molecular biomarkers from pathology slides
Deep Learning (DL) can predict biomarkers from cancer histopathology. Several clinically approved applications use this technology. Most approaches,...
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Gut inflammation associated with age and Alzheimer’s disease pathology: a human cohort study
Age-related disease may be mediated by low levels of chronic inflammation (“inflammaging”). Recent work suggests that gut microbes can contribute to...
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Native-state proteomics of Parvalbumin interneurons identifies unique molecular signatures and vulnerabilities to early Alzheimer’s pathology
Dysfunction in fast-spiking parvalbumin interneurons (PV-INs) may represent an early pathophysiological perturbation in Alzheimer’s Disease (AD)....
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Bridging clinic and wildlife care with AI-powered pan-species computational pathology
Cancers occur across species. Understanding what is consistent and varies across species can provide new insights into cancer initiation and...
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Three-dimensional identification of microvascular pathology and neurovascular inflammation in severe white matter hyperintensity: a case report
White matter hyperintensities (WMH) are the most prevalent markers of cerebral small vessel disease (SVD), which is the major vascular risk factor...
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An aging, pathology burden, and glial senescence build-up hypothesis for late onset Alzheimer’s disease
Alzheimer’s disease (AD) predominantly occurs as a late onset (LOAD) form involving neurodegeneration and cognitive decline with progressive memory...
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Adversarial attacks and adversarial robustness in computational pathology
Artificial Intelligence (AI) can support diagnostic workflows in oncology by aiding diagnosis and providing biomarkers directly from routine...
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A Multimodal Generative AI Copilot for Human Pathology
The field of computational pathology[1,2] has witnessed remarkable progress in the development of both task-specific predictive models and...
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The mediating role of synovitis in meniscus pathology and knee osteoarthritis radiographic progression
Meniscus pathologies (damage, extrusion) and synovitis are associated with knee osteoarthritis (KOA); however, whether synovitis mediates the...
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A generative adversarial network model alternative to animal studies for clinical pathology assessment
Animal studies are unavoidable in evaluating chemical and drug safety. Generative Adversarial Networks (GANs) can generate synthetic animal data by...
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Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice
A20 serves as a critical brake on NF-κB-dependent inflammation. In humans, polymorphisms in or near the TNFAIP3/A20 gene have been linked to various...
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Quantitative analysis of prion disease using an AI-powered digital pathology framework
Prion disease is a fatal neurodegenerative disorder characterized by accumulation of an abnormal prion protein (PrPSc) in the central nervous system....
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Association of triglyceride glucose-body mass index with Alzheimer’s disease pathology, cognition and brain structure in non-demented people
The relationship between the triglyceride glucose-body mass index (TyG-BMI) index and Alzheimer’s disease (AD) pathology, cognition, and brain...
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Critical evaluation of artificial intelligence as a digital twin of pathologists for prostate cancer pathology
Prostate cancer pathology plays a crucial role in clinical management but is time-consuming. Artificial intelligence (AI) shows promise in detecting...
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Disease pathology signatures in a mouse model of Mucopolysaccharidosis type IIIB
Mucopolysaccharidosis type IIIB (MPS IIIB) is a rare and devastating childhood-onset lysosomal storage disease caused by complete loss of function of...
