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Association of gout with brain reserve and vulnerability to neurodegenerative disease
Studies of neurodegenerative disease risk in gout are contradictory. Relationships with neuroimaging markers of brain structure, which may offer...
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Disease stages and therapeutic hypotheses in two decades of neurodegenerative disease clinical trials
Neurodegenerative disease is increasingly prevalent and remains without disease-modifying therapies. Engaging the right target, at the right disease...
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Darier disease is associated with neurodegenerative disorders and epilepsy
Darier disease (DD) is a rare monogenetic skin disorder with limited data on its potential association with neurological disorders. This study aimed...
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Inflammatory and neurodegenerative serum protein biomarkers increase sensitivity to detect clinical and radiographic disease activity in multiple sclerosis
The multifaceted nature of multiple sclerosis requires quantitative biomarkers that can provide insights related to diverse physiological pathways....
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Neurotoxicity of diesel exhaust extracts in zebrafish and its implications for neurodegenerative disease
Long-term air pollution (AP) exposure, including diesel exhaust exposure, is increasingly being recognized as a major contributor to the development...
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Multi sequence average templates for aging and neurodegenerative disease populations
Magnetic resonance image (MRI) processing pipelines use average templates to enable standardization of individual MRIs in a common space. MNI-ICBM152...
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Temperature-related death burden of various neurodegenerative diseases under climate warming: a nationwide modelling study
Limited knowledge exists regarding the ramifications of climate warming on death burden from neurodegenerative diseases. Here, we conducted a...
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Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids
Abnormal assembly of tau, α-synuclein, TDP-43 and amyloid-β proteins into amyloid filaments defines most human neurodegenerative diseases. Genetics...
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PhagoStat a scalable and interpretable end to end framework for efficient quantification of cell phagocytosis in neurodegenerative disease studies
Quantifying the phagocytosis of dynamic, unstained cells is essential for evaluating neurodegenerative diseases. However, measuring rapid cell...
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Shared mechanisms across the major psychiatric and neurodegenerative diseases
Several common psychiatric and neurodegenerative diseases share epidemiologic risk; however, whether they share pathophysiology is unclear and is the...
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Neuropathogenesis-on-chips for neurodegenerative diseases
Develo** diagnostics and treatments for neurodegenerative diseases (NDs) is challenging due to multifactorial pathogenesis that progresses...
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Shared molecular signatures between coronavirus infection and neurodegenerative diseases provide targets for broad-spectrum drug development
Growing evidences have suggested the association between coronavirus infection and neurodegenerative diseases. However, the molecular mechanism...
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Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases
Microglial activation plays central roles in neuroinflammatory and neurodegenerative diseases. Positron emission tomography (PET) targeting 18 kDa...
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The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases
A positron emission tomography (PET) tracer detecting α-synuclein pathology will improve the diagnosis, and ultimately the treatment of...
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Blood biomarker-based classification study for neurodegenerative diseases
As the population ages, neurodegenerative diseases are becoming more prevalent, making it crucial to comprehend the underlying disease mechanisms and...
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Astrocytes’ innate role in neurodegenerative disorders
BackgroundCentral nervous system (CNS) astrocytes have various functions in the central nervous system (CNS). Many neurodegenerative diseases are...
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Effects of microbiome-based interventions on neurodegenerative diseases: a systematic review and meta-analysis
Neurodegenerative diseases (NDDs) are characterized by neuronal damage and progressive loss of neuron function. Microbiome-based interventions, such...
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Assessing causal relationship between circulating cytokines and age-related neurodegenerative diseases: a bidirectional two-sample Mendelian randomization analysis
Numerous studies have reported that circulating cytokines (CCs) are linked to age-related neurodegenerative diseases (ANDDs); however, there is a...
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Nonlocal models in the analysis of brain neurodegenerative protein dynamics with application to Alzheimer’s disease
It is well known that today nearly one in six of the world’s population has to deal with neurodegenerative disorders. While a number of medical...
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An infrared spectral biomarker accurately predicts neurodegenerative disease class in the absence of overt symptoms
Although some neurodegenerative diseases can be identified by behavioral characteristics relatively late in disease progression, we currently lack...
