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Mucosal-associated invariant T cells contribute to suppression of inflammatory myeloid cells in immune-mediated kidney disease
Mucosal-associated invariant T (MAIT) cells have been implicated in various inflammatory diseases of barrier organs, but so far, their role in kidney...
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Characterization of the TCRβ repertoire of peripheral MR1-restricted MAIT cells in psoriasis vulgaris patients
Psoriasis vulgaris (PV) is an inflammatory skin disease largely driven by aberrant αβT cells. Mucosal-associated invariant T (MAIT) cells, which...
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MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming
Recent data have shown that liver fibrosis can regress even at later stages of cirrhosis and shifting the immune response from pro-inflammatory...
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Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy
Immune checkpoint inhibitors are used for treating patients with metastatic melanoma. Since the response to treatment is variable, biomarkers are...
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Mucosal-associated invariant T (MAIT) cells provide B-cell help in vaccinated and subsequently SIV-infected Rhesus Macaques
Mucosal-associated invariant T (MAIT) cells help combat opportunistic infections. Thus, MAIT cells are of interest in HIV/SIV vaccination and...
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Differential location of NKT and MAIT cells within lymphoid tissue
Natural Killer T (NKT) cells and Mucosal-Associated Invariant T (MAIT) cells are innate-like T cells that express semi-invariant αβ T cell receptors...
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Invariant γδTCR natural killer-like effector T cells in the naked mole-rat
The naked mole-rat ( Heterocephalus glaber ) is a long-lived rodent species showing resistance to the development of cancer. Although naked mole-rats...
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MAIT cells regulate NK cell-mediated tumor immunity
The function of MR1-restricted mucosal-associated invariant T (MAIT) cells in tumor immunity is unclear. Here we show that MAIT cell-deficient mice...
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Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity
Obesity is associated with low-grade chronic inflammation promoting insulin-resistance and diabetes. Gut microbiota dysbiosis is a consequence as...
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Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b
MHC class I-related protein 1 (MR1) is a metabolite-presenting molecule that restricts MR1-reactive T cells including mucosal-associated invariant T...
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Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection
Mucosal-associated Invariant T (MAIT) cells are recognized for their antibacterial functions. The protective capacity of MAIT cells has been...
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Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals
Mucosal-associated invariant T (MAIT) cells have important functions in immune responses against pathogens and in diseases, but mechanisms...
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Intrinsic factors and CD1d1 but not CD1d2 expression levels control invariant natural killer T cell subset differentiation
Invariant natural killer T (NKT) cell subsets are defined based on their cytokine-production profiles and transcription factors. Their distribution...
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In vitro Interleukin-7 treatment partially rescues MAIT cell dysfunction caused by SARS-CoV-2 infection
MAIT cells have been shown to be activated upon several viral infections in a TCR-independent manner by responding to inflammatory cytokines secreted...
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Activation of mucosal-associated invariant T cells in the lungs of sarcoidosis patients
Although the pathogenesis of sarcoidosis is not fully understood, immunological characterization has elucidated highly polarized expression of the...
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Alternative splicing of MR1 regulates antigen presentation to MAIT cells
Mucosal Associated Invariant T (MAIT) cells can sense intracellular infection by a broad array of pathogens. These cells are activated upon...
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Distinct gene expression signatures comparing latent tuberculosis infection with different routes of Bacillus Calmette-Guérin vaccination
Tuberculosis remains an international health threat partly because of limited protection from pulmonary tuberculosis provided by standard intradermal...
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Low-dose IL-2 reduces IL-21+ T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes
Despite early clinical successes, the mechanisms of action of low-dose interleukin-2 (LD-IL-2) immunotherapy remain only partly understood. Here we...
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Differences in the molecular signatures of mucosal-associated invariant T cells and conventional T cells
Mucosal-associated invariant T (MAIT) cells exhibit different characteristics from those of TCRα7.2 − conventional T cells. They play important roles...
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Immune phenotypes that are associated with subsequent COVID-19 severity inferred from post-recovery samples
Severe COVID-19 causes profound immune perturbations, but pre-infection immune signatures contributing to severe COVID-19 remain unknown. Genome-wide...
