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Evaluation of drug-induced liver toxicity of trovafloxacin and levofloxacin in a human microphysiological liver model
Drug-induced liver injury induced by already approved substances is a major threat to human patients, potentially resulting in drug withdrawal and...
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High methionine diet mediated oxidative stress and proteasome impairment causes toxicity in liver
Methionine (Met) rich diet inducing oxidative stress is reported to alter many organs. Proteasome as a regulator of oxidative stress can be targeted....
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The mitochondrial fusion protein OPA1 is dispensable in the liver and its absence induces mitohormesis to protect liver from drug-induced injury
Mitochondria are critical for metabolic homeostasis of the liver, and their dysfunction is a major cause of liver diseases. Optic atrophy 1 (OPA1) is...
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Biological toxicity of sulfamethoxazole in aquatic ecosystem on adult zebrafish (Danio rerio)
This study evaluated the impacts of sulfamethoxazole (SMX) on antioxidant, immune, histopathological dynamic changes, and gut microbiota of...
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Heavy metal toxicity arising from the industrial effluents repercussions on oxidative stress, liver enzymes and antioxidant activity in brain homogenates of Oreochromis niloticus
Industrial effluents reaching to the aquatic ecosystem is one of the major causes of environmental pollution and exposure to industrial effluents...
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Toxicity mechanisms of aflatoxin M1 assisted with molecular docking and the toxicity-limiting role of trans-resveratrol
In this study, AFM 1 toxicity and the protective role of trans-resveratrol (t-rsv) against this toxicity were investigated with the help of multiple...
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Hepa-ToxMOA: a pathway-screening method for evaluating cellular stress and hepatic metabolic-dependent toxicity of natural products
In the field of drug discovery, natural products have emerged as therapeutic agents for diseases such as cancer. However, their potential toxicity...
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Lambda-cyhalothrin-induced pancreatic toxicity in adult albino rats
Lambda-cyhalothrin (LCT) is one of the most frequently utilized pyrethroids. This study aimed to explore the toxic effects of subacute exposure to...
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Genetic polymorphisms and clinical parameters associated with renal toxicity in Thai hematologic malignancy patients receiving high dose methotrexate
High-dose methotrexate (HD-MTX) is a widely used chemotherapy regimen for hematologic malignancies such as lymphomas and acute lymphoblastic...
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Interactions of anti-COVID-19 drug candidates with hepatic transporters may cause liver toxicity and affect pharmacokinetics
Transporters in the human liver play a major role in the clearance of endo- and xenobiotics. Apical (canalicular) transporters extrude compounds to...
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Oxidative stress mediates end-organ damage in a novel model of acetaminophen-toxicity in Drosophila
Acetaminophen is the most common cause of acute drug-induced liver injury in the United States. However, research into the mechanisms of...
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Multimodal decoding of human liver regeneration
The liver has a unique ability to regenerate
1 ,2 ; however, in the setting of acute liver failure (ALF), this regenerative capacity is often...
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In vivo toxicity evaluation of a polyoxotungstate nanocluster as a promising contrast agent for computed tomography
In this study, we demonstrate for the first time, that a discrete metal-oxo cluster α-/β-K 6 P 2 W 18 O 62 (WD-POM) exhibits superior performance as a...
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The “Green Liver” Concept: Green Liver Systems as Low-Impact Systems for Bioremediation Using Aquatic Macrophytes
Systems with aquatic macrophytes have been developed as low-impact, low-energy, and low-cost solutions for the remediation of water pollutants. As...
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Oxidative stress, inflammation, and steatosis elucidate the complex dynamics of HgCl2 induced liver damage in Channa punctata
Water bodies are highly pollution-prone areas in which mercury (Hg) is considered as a major menace to aquatic organisms. However, the information...
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Biocompatibility and sub-chronic toxicity studies of phlorotannin/polycaprolactone coated trachea tube for advancing medical device applications
The phlorotannin-polycaprolactone-coated endotracheal tube (PP tube) has been developed with the aim of preventing tracheal stenosis that can result...
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Lysyl oxidase-like 3 restrains mitochondrial ferroptosis to promote liver cancer chemoresistance by stabilizing dihydroorotate dehydrogenase
To overcome chemotherapy resistance, novel strategies sensitizing cancer cells to chemotherapy are required. Here, we screen the lysyl-oxidase (LOX)...
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A comparative multi-level toxicity assessment of carbon-based Gd-free dots and Gd-doped nanohybrids from coffee waste: hematology, biochemistry, histopathology and neurobiology study
Here, a comparative toxicity assessment of precursor carbon dots from coffee waste (cofCDs) obtained using green chemistry principles and Gd-doped...
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Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity
Fasting exerts beneficial effects in mice and humans, including protection from chemotherapy toxicity. To explore the involved mechanisms, we collect...
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Micropatterned primary hepatocyte co-culture (HEPATOPAC) for fatty liver disease modeling and drug screening
Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent, progressive disorder and growing public health concern. To address this issue...
