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LSD1 drives intestinal epithelial maturation and controls small intestinal immune cell composition independent of microbiota in a murine model
Postnatal development of the gastrointestinal tract involves the establishment of the commensal microbiota, the acquisition of immune tolerance via a...
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Establishment of a novel obesity mouse model: the induction of intestinal microbiota dysbiosis
To establish and evaluate an intestinal microbiota dysbiosis-induced obesity mouse model. 50 C57BL/6 J male healthy mice were randomly divided into...
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Ribonuclease 4 functions as an intestinal antimicrobial protein to maintain gut microbiota and metabolite homeostasis
Antimicrobial proteins contribute to host-microbiota interactions and are associated with inflammatory bowel disease (IBD), but our understanding on...
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Metagenomic comparison of intestinal microbiota between normal and liver fibrotic rhesus macaques (Macaca mulatta)
Liver fibrosis is an important pathological process in chronic liver disease and cirrhosis. Recent studies have found a close association between...
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Glucose-fed microbiota alters C. elegans intestinal epithelium and increases susceptibility to multiple bacterial pathogens
Overconsumption of dietary sugar can lead to many negative health effects including the development of Type 2 diabetes, metabolic syndrome,...
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Regulation of psoriasis, colitis, and the intestinal microbiota by clusterin
Psoriasis, a chronic and systemic inflammatory disorder characterized by activation of the interleukin (IL)-23/IL-17 axis, may be associated with the...
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Study on intestinal parasitic infections and gut microbiota in cancer patients at a tertiary teaching hospital in Malaysia
Intestinal parasitic infections (IPIs) can lead to significant morbidity and mortality in cancer patients. While they are unlikely to cause severe...
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Apple polysaccharide improves age-matched cognitive impairment and intestinal aging through microbiota-gut-brain axis
The Apple polysaccharides (AP), extracted from the fruit of apple, has been used to treat multiple pathological diseases. In this study, we evaluated...
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Systems biology approaches to identify potential targets and inhibitors of the intestinal microbiota to treat depression
Depression is a common mental disease, with some patients exhibiting ideas and behaviors such as self-harm and suicide. The drugs currently used to...
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Diet replacement with whole insect larvae affects intestinal morphology and microbiota of broiler chickens
Insect-based diets are gaining interest as potential ingredients in improving poultry gut health. This study assessed the dietary treatment with...
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Effects of plant-based proteins and handling stress on intestinal mucus microbiota in rainbow trout
Via 16S rRNA gene amplicon sequencing, this study explores whether the gut mucus microbiota of rainbow trout is affected by the interaction of a...
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Small intestinal microbiota composition altered in obesity-T2DM mice with high salt fed
Obesity has become a global concern because of increasing the risk of many diseases. Alterations in human gut microbiota have been proven to be...
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Alterations in intestinal microbiota in ultramarathon runners
To date, only one study has reported changes in the gut microbiome of an ultramarathon runner before and after competing in the race. Herein we aimed...
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A neurotherapeutic approach with Lacticaseibacillus rhamnosus E9 on gut microbiota and intestinal barrier in MPTP-induced mouse model of Parkinson’s disease
The gut microbiota plays a crucial role in neural development and progression of neural disorders like Parkinson’s disease (PD). Probiotics have been...
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Enterohaemorrhagic E. coli utilizes host- and microbiota-derived L-malate as a signaling molecule for intestinal colonization
The mammalian gastrointestinal tract is a complex environment that hosts a diverse microbial community. To establish infection, bacterial pathogens...
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Severe, short-term sleep restriction reduces gut microbiota community richness but does not alter intestinal permeability in healthy young men
Sleep restriction alters gut microbiota composition and intestinal barrier function in rodents, but whether similar effects occur in humans is...
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Colitis-associated intestinal microbiota regulates brain glycine and host behavior in mice
Inflammatory bowel diseases (IBD) are chronic and relapsing inflammatory disorders of the gastrointestinal tract with complex etiology and no...
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A diet rich in fermentable fiber promotes robust changes in the intestinal microbiota, mitigates intestinal permeability, and attenuates autoimmune uveitis
Therapeutic approaches for noninfectious uveitis have expanded greatly over the past 10 years, but are limited by potential side effects and limited...
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Bacillus coagulans MZY531 alleviates intestinal mucosal injury in immunosuppressive mice via modulating intestinal barrier, inflammatory response, and gut microbiota
Bacillus coagulans has a potential role in improving intestinal injury. However, the specific mechanism is still unclear. In this study, the...
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Gut microbiota regulates acute myeloid leukaemia via alteration of intestinal barrier function mediated by butyrate
The gut microbiota has been linked to many cancers, yet its role in acute myeloid leukaemia (AML) progression remains unclear. Here, we show...
