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Endonucleosis mediates internalization of cytoplasm into the nucleus
Setd8 regulates transcription elongation, mitotic DNA condensation, DNA damage response and replication licensing. Here we show that, in...
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Acute deletion of TET enzymes results in aneuploidy in mouse embryonic stem cells through decreased expression of Khdc3
TET (Ten-Eleven Translocation) dioxygenases effect DNA demethylation through successive oxidation of the methyl group of 5-methylcytosine (5mC) in...
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Cell cycle reentry triggers hyperploidization and synaptic dysfunction followed by delayed cell death in differentiated cortical neurons
Cell cycle reentry followed by neuronal hyperploidy and synaptic failure are two early hallmarks of Alzheimer’s disease (AD), however their...
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Nanoformulated rosemary extract impact on oral cancer: in vitro study
BackgroundTreating cancer is challenging for both the patient and the physician. This may be explained by the fact that treatment regimens rely on...
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Cytomorphological Evaluation of Cultivated and Wild Bitter Gourds (Momordica charantia L.) of Jammu Province
Two forms of wild bitter gourd i.e. Momordica charantia var. muricata from Palli and Purmandal and three forms of cultivated bitter gourd viz. Momordic...
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Evolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling
Although melanoma is initiated by acquisition of point mutations and limited focal copy number alterations in melanocytes-of-origin, the nature of...
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HER2, chromosome 17 polysomy and DNA ploidy status in breast cancer; a translational study
Breast cancer treatment depends on human epidermal growth factor receptor-2 (HER2) status, which is often determined using dual probe fluorescence in...
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An actin filament branching surveillance system regulates cell cycle progression, cytokinesis and primary ciliogenesis
Dysfunction of cell cycle control and defects of primary ciliogenesis are two features of many cancers. Whether these events are interconnected and...
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Establishment and genomic characterization of gingivobuccal carcinoma cell lines with smokeless tobacco associated genetic alterations and oncogenic PIK3CA mutation
Smokeless tobacco associated Gingivobuccal squamous cell carcinoma (GB-SCC) is a major public health problem but available oral cancer cell lines are...
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Occurrence of the Two Cytotypes of Ferula jaeschkeana Vatke in Kashmir Himalaya
The information regarding chromosome counts and meiotic behavior is important to understand the plant evolution and diversification. Kee** in view...
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Re-enforcing hypoxia-induced polyploid cardiomyocytes enter cytokinesis through activation of β-catenin
Cardiomyocyte (CM) loss is a characteristic of various heart diseases, including ischaemic heart disease. Cardiac regeneration has been suggested as...
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Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model
Transformation of castration-resistant prostate cancer (CRPC) into an aggressive neuroendocrine disease (CRPC-NE) represents a major clinical...
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Steroid Receptor Coactivator-2 Controls the Pentose Phosphate Pathway through RPIA in Human Endometrial Cancer Cells
Steroid receptor coactivator-2 (SRC-2) is a transcriptional coregulator that modulates the activity of many transcription factors. Levels of SRC-2...
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A lack of coordination between sister-chromatids segregation and cytokinesis in the oocytes of B6.YTIR (XY) sex-reversed female mice
The B6.Y TIR (XY) mouse develops bilateral ovaries despite the expression of the testis-determining gene Sry during gonadal differentiation. We...
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Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors
Colorectal carcinoma represents a heterogeneous entity, with only a fraction of the tumours responding to available therapies, requiring a better...
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Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors
It has been postulated that imprinting aberrations are common in tumors. To understand the role of imprinting in cancer, we have characterized...
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The whole-genome landscape of medulloblastoma subtypes
Current therapies for medulloblastoma, a highly malignant childhood brain tumour, impose debilitating effects on the develo** child, and highlight...
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A network of genes connects polyglutamine toxicity to ploidy control in yeast
Neurodegeneration is linked to protein aggregation in several human disorders. In Huntington’s disease, the length of a polyglutamine stretch in...
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ALKBH4-dependent demethylation of actin regulates actomyosin dynamics
Regulation of actomyosin dynamics by post-transcriptional modifications in cytoplasmic actin is still poorly understood. Here we demonstrate that...
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Oncogenic mutations of ALK kinase in neuroblastoma
Neuroblastoma in advanced stages is one of the most intractable paediatric cancers, even with recent therapeutic advances
1 . Neuroblastoma harbours a...