Search
Search Results
-
Human archetypal pluripotent stem cells differentiate into trophoblast stem cells via endogenous BMP5/7 induction without transitioning through naive state
Primary human trophoblast stem cells (TSCs) and TSCs derived from human pluripotent stem cells (hPSCs) can potentially model placental processes in...
-
Hypoblast from human pluripotent stem cells regulates epiblast development
Recently, several studies using cultures of human embryos together with single-cell RNA-seq analyses have revealed differences between humans and...
-
ZBTB12 is a molecular barrier to dedifferentiation in human pluripotent stem cells
Development is generally viewed as one-way traffic of cell state transition from primitive to developmentally advanced states. However, molecular...
-
In vitro induction of patterned branchial arch-like aggregate from human pluripotent stem cells
Early patterning of neural crest cells (NCCs) in the craniofacial primordium is important for subsequent development of proper craniofacial...
-
Efficient generation of a self-organizing neuromuscular junction model from human pluripotent stem cells
The complex neuromuscular network that controls body movements is the target of severe diseases that result in paralysis and death. Here, we report...
-
Maturation of human cardiomyocytes derived from induced pluripotent stem cells (iPSC-CMs) on polycaprolactone and polyurethane nanofibrous mats
Investigating the potential of human cardiomyocytes derived from induced pluripotent stem cells (iPSC-CMs) in in vitro heart models is essential to...
-
Estimating residual undifferentiated cells in human chemically induced pluripotent stem cell derived islets using lncRNA as biomarkers
Human pluripotent stem cells (hPSCs) can generate insulin-producing beta cells for diabetes treatment, but residual undifferentiated cells may cause...
-
Self-renewing human naïve pluripotent stem cells dedifferentiate in 3D culture and form blastoids spontaneously
Human naïve pluripotent stem cells (hnPSCs) can generate integrated models of blastocysts termed blastoids upon switch to inductive medium. However,...
-
Machine learning discriminates P2X7-mediated intracellular calcium sparks in human-induced pluripotent stem cell-derived neural stem cells
Adenosine triphosphate (ATP) is an extracellular signaling molecule that mainly affects the pathophysiological situation in the body and can be...
-
A novel efficient strategy to generate liver sinusoidal endothelial cells from human pluripotent stem cells
Liver sinusoidal endothelial cells (LSECs) are highly specialized endothelial cells (ECs) that play an important role in liver development and...
-
Modeling cardiac fibroblast heterogeneity from human pluripotent stem cell-derived epicardial cells
Cardiac fibroblasts play an essential role in the development of the heart and are implicated in disease progression in the context of fibrosis and...
-
Simulated microgravity improves maturation of cardiomyocytes derived from human induced pluripotent stem cells
Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) possess tremendous potential for basic research and translational...
-
Laminin fragments conjugated with perlecan’s growth factor-binding domain differentiate human induced pluripotent stem cells into skin-derived precursor cells
Deriving stem cells to regenerate full-thickness human skin is important for treating skin disorders without invasive surgical procedures. Our...
-
Chemical reprogramming of human somatic cells to pluripotent stem cells
Cellular reprogramming can manipulate the identity of cells to generate the desired cell types
1 –3 . The use of cell intrinsic components, including...
-
Unsupervised analysis of whole transcriptome data from human pluripotent stem cells cardiac differentiation
The main objective of the present work was to highlight differences and similarities in gene expression patterns between different pluripotent stem...
-
Effective SARS-CoV-2 replication of monolayers of intestinal epithelial cells differentiated from human induced pluripotent stem cells
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes severe acute respiratory symptoms in humans. Controlling the coronavirus disease...
-
Integration-free induced pluripotent stem cells from three endangered Southeast Asian non-human primate species
Advanced molecular and cellular technologies provide promising tools for wildlife and biodiversity conservation. Induced pluripotent stem cell (iPSC)...
-
ROR2 expression predicts human induced pluripotent stem cell differentiation into neural stem/progenitor cells and GABAergic neurons
Despite the development of various in vitro differentiation protocols for the efficient derivation of specific cell types, human induced pluripotent...
-
Tau tubulin kinase 1 and 2 regulate ciliogenesis and human pluripotent stem cells–derived neural rosettes
Primary cilia are key regulators of embryo development and tissue homeostasis. However, their mechanisms and functions, particularly in the context...
-
Role of UPF1-LIN28A interaction during early differentiation of pluripotent stem cells
UPF1 and LIN28A are RNA-binding proteins involved in post-transcriptional regulation and stem cell differentiation. Most studies on UPF1 and LIN28A...
