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Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization
Cortical spreading depolarization (CSD) is a propagating wave of tissue depolarization characterized by a large increase of extracellular potassium...
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Astroglial Kir4.1 potassium channel deficit drives neuronal hyperexcitability and behavioral defects in Fragile X syndrome mouse model
Fragile X syndrome (FXS) is an inherited form of intellectual disability caused by the loss of the mRNA-binding fragile X mental retardation protein...
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Klotho is highly expressed in the chief sites of regulated potassium secretion, and it is stimulated by potassium intake
Klotho regulates many pathways in the aging process, but it remains unclear how it is physiologically regulated. Because Klotho is synthesized,...
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Probing intracellular potassium dynamics in neurons with the genetically encoded sensor lc-LysM GEPII 1.0 in vitro and in vivo
Neuronal activity is accompanied by a net outflow of potassium ions (K + ) from the intra- to the extracellular space. While extracellular [K + ] changes...
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Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1
Tandem pore domain (K2P) potassium channels modulate resting membrane potentials and shape cellular excitability. For the mechanosensitive subfamily...
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Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation
Potassium channels of the Two-Pore Domain (K2P) subfamily, KCNK1-KCNK18 , play crucial roles in controlling the electrical activity of many different...
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Low potassium activation of proximal mTOR/AKT signaling is mediated by Kir4.2
The renal epithelium is sensitive to changes in blood potassium (K + ). We identify the basolateral K + channel, Kir4.2, as a mediator of the proximal...
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Central cavity dehydration as a gating mechanism of potassium channels
The hydrophobic gating model, in which ion permeation is inhibited by the hydrophobicity, rather than a physical occlusion of the nanopore, functions...
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Cloning, functional expression, and pharmacological characterization of inwardly rectifying potassium channels (Kir) from Apis mellifera
Potassium channels belong to the super family of ion channels and play a fundamental role in cell excitability. Kir channels are potassium channels...
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Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators
The Kv1.3 potassium channel is expressed abundantly on activated T cells and mediates the cellular immune response. This role has made the channel a...
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Cryo-EM structures of recombinant human sodium-potassium pump determined in three different states
Sodium-Potassium Pump (Na + /K + -ATPase, NKA) is an ion pump that generates an electrochemical gradient of sodium and potassium ions across the plasma...
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Extracellular DNA traps in a ctenophore demonstrate immune cell behaviors in a non-bilaterian
The formation of extracellular DNA traps (ETosis) is a first response mechanism by specific immune cells following exposure to microbes. Initially...
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Neutrophil extracellular traps promote immunopathogenesis of virus-induced COPD exacerbations
Respiratory viruses are a major trigger of exacerbations in chronic obstructive pulmonary disease (COPD). Airway neutrophilia is a hallmark feature...
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Machine learning models for early prediction of potassium lowering effectiveness and adverse events in patients with hyperkalemia
The aim of this study was to develop a model for early prediction of adverse events and treatment effectiveness in patients with hyperkalemia. We...
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Differential proteomics of tobacco seedling roots at high and low potassium concentrations
The effects of high potassium and normal potassium treatments on protein expression in roots of flue-cured tobacco plant HKDN-5 at the seedling stage...
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Native American ataxia medicines rescue ataxia-linked mutant potassium channel activity via binding to the voltage sensing domain
There are currently no drugs known to rescue the function of Kv1.1 voltage-gated potassium channels carrying loss-of-function sequence variants...
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Effect of hypercholesterolemia on circulating and cardiomyocyte-derived extracellular vesicles
Hypercholesterolemia (HC) induces, propagates and exacerbates cardiovascular diseases via various mechanisms that are yet not properly understood....
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Comparison of goat and cow milk-derived extracellular vesicle miRNomes
miRNAs present in milk are mainly found in extracellular vesicles (EVs), which are nanosized membrane vesicles released by most of the cell types to...
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N-hydroxypipecolic acid triggers systemic acquired resistance through extracellular NAD(P)
Systemic acquired resistance (SAR) is a long-lasting broad-spectrum plant defense mechanism induced in distal systemic tissues by mobile signals...
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Widespread extracellular electron transfer pathways for charging microbial cytochrome OmcS nanowires via periplasmic cytochromes PpcABCDE
Extracellular electron transfer (EET) via microbial nanowires drives globally-important environmental processes and biotechnological applications for...
