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In vitro replicative potential of an HIV-1/MO intergroup recombinant virus compared to HIV-1/M and HIV-1/O parental viruses
Genetic recombination is one of the major evolution processes of HIV-1. Despite their great genetic divergence, HIV-1 groups M and O can generate...
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Trispecific antibody targeting HIV-1 and T cells activates and eliminates latently-infected cells in HIV/SHIV infections
Agents that can simultaneously activate latent HIV, increase immune activation and enhance the killing of latently-infected cells represent promising...
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The experienced positive and negative influence of HIV on quality of life of people with HIV and vulnerable to HIV in the Netherlands
This qualitative study aimed to explore the experienced influence of HIV on the quality of life (QoL) of people with HIV (PHIV) and key populations...
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CRISPR/Cas9 genome editing of CCR5 combined with C46 HIV-1 fusion inhibitor for cellular resistant to R5 and X4 tropic HIV-1
Hematopoietic stem-cell (HSC) transplantation using a donor with a homozygous mutation in the HIV co-receptor CCR5 (CCR5Δ32/Δ32) holds great promise...
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HIV/AIDS stigma accumulation among people living with HIV: a role of general and relative minority status
The main objective of the study was to investigate the relationship between selected sociodemographic factors (i.e. sexual orientation, gender and...
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Associations between HIV stigma and health-related quality-of-life among people living with HIV: cross-sectional analysis of data from HPTN 071 (PopART)
People living with HIV (PLHIV) report lower health-related quality-of-life (HRQoL) than HIV-negative people. HIV stigma may contribute to this. We...
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RAIN: machine learning-based identification for HIV-1 bNAbs
Broadly neutralizing antibodies (bNAbs) are promising candidates for the treatment and prevention of HIV-1 infections. Despite their critical...
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RPLP1 restricts HIV-1 transcription by disrupting C/EBPβ binding to the LTR
Long-term non-progressors (LTNPs) of HIV-1 infection may provide important insights into mechanisms involved in viral control and pathogenesis. Here,...
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HIV-1 diverts cortical actin for particle assembly and release
Enveloped viruses assemble and bud from the host cell membranes. Any role of cortical actin in these processes have often been a source of debate....
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Syphilis screening coverage and positivity by HIV treatment status among South African pregnant women enrolled in the 2019 antenatal HIV sentinel survey
We describe coverage of maternal syphilis screening, syphilis positivity, coverage of treatment and their association with maternal HIV infection and...
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Distinct cytokine profiles in late pregnancy in Ugandan people with HIV
During pregnancy, multiple immune regulatory mechanisms establish an immune-tolerant environment for the allogeneic fetus, including cellular signals...
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HIV-associated gut microbial alterations are dependent on host and geographic context
HIV-associated changes in intestinal microbiota are believed to be important drivers of disease progression. However, the majority of studies have...
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Spatial–temporal transmission dynamics of HIV-1 CRF01_AE in Indonesia
Human immunodeficiency virus type 1 (HIV-1) remains a serious health threat in Indonesia. In particular, the CRF01_AE viruses were the predominant...
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HIV-1 RNA in extracellular vesicles is associated with neurocognitive outcomes
Human immunodeficiency virus type-1 (HIV-1) is responsible for significant mortality and morbidity worldwide. Despite complete control of viral...
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Prevalence of malaria infection and factors associated among HIV-infected adult patients attending HIV care and treatment clinic at Kitete regional referral hospital in Tabora region, Tanzania: a cross-sectional study
BackgroundHIV and malaria are serious public health concerns, particularly in Tanzania. HIV-infected individuals are more likely to get malaria and...
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The HIV capsid mimics karyopherin engagement of FG-nucleoporins
HIV can infect non-dividing cells because the viral capsid can overcome the selective barrier of the nuclear pore complex and deliver the genome...
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HIV transmission dynamics and population-wide drug resistance in rural South Africa
Despite expanded antiretroviral therapy (ART) in South Africa, HIV-1 transmission persists. Integrase strand transfer inhibitors (INSTI) and...
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The role of resilience in daily experiences of posttraumatic growth, affect, and HIV/AIDS stigma among people living with HIV
This study investigated the intraindividual variability in daily posttraumatic growth (PTG) versus posttraumatic depreciation (PTD), positive and...
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CoPoP liposomes displaying stabilized clade C HIV-1 Env elicit tier 2 multiclade neutralization in rabbits
One of the strategies towards an effective HIV-1 vaccine is to elicit broadly neutralizing antibody responses that target the high HIV-1 Env...
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Trend and principal components of HIV/AIDS among adults in SSA
This study aimed to identify the most important principal components (PCs) that contribute to the prevalence and change of HIV/AIDS in 44 SSA and...
