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Downregulation of Roundabout guidance receptor 2 suppresses hepatocellular carcinoma progression by interacting with Y-box binding protein 1
Roundabout guidance receptor 2 (Robo2) is closely related to malignant tumors such as pancreatic cancer and liver fibrosis, but there is no relevant...
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Guidance landscapes unveiled by quantitative proteomics to control reinnervation in adult visual system
In the injured adult central nervous system (CNS), activation of pro-growth molecular pathways in neurons leads to long-distance regeneration....
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Predictive model for cytoneme guidance in Hedgehog signaling based on Ihog- Glypicans interaction
During embryonic development, cell-cell communication is crucial to coordinate cell behavior, especially in the generation of differentiation...
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Repulsive guidance molecule acts in axon branching in Caenorhabditis elegans
Repulsive guidance molecules (RGMs) are evolutionarily conserved proteins implicated in repulsive axon guidance. Here we report the function of the Cae...
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Multiomics analysis reveals that hepatocyte nuclear factor 1β regulates axon guidance genes in the develo** mouse kidney
The transcription factor hepatocyte nuclear factor 1β (HNF-1β) is essential for normal development of the kidney and other epithelial organs. In the...
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Binding kinetics drive G protein subtype selectivity at the β1-adrenergic receptor
G protein-coupled receptors (GPCRs) bind to different G protein α-subtypes with varying degrees of selectivity. The mechanism by which GPCRs achieve...
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Structural basis of amine odorant perception by a mammal olfactory receptor
Odorants are detected as smell in the nasal epithelium of mammals by two G-protein-coupled receptor families, the odorant receptors and the trace...
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Intermediate-state-trapped mutants pinpoint G protein-coupled receptor conformational allostery
Understanding the roles of intermediate states in signaling is pivotal to unraveling the activation processes of G protein-coupled receptors (GPCRs)....
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Design of a water-soluble transmembrane receptor kinase with intact molecular function by QTY code
Membrane proteins are critical to biological processes and central to life sciences and modern medicine. However, membrane proteins are notoriously...
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Molecular mechanism of biased signaling at the kappa opioid receptor
The κ-opioid receptor (KOR) has emerged as an attractive drug target for pain management without addiction, and biased signaling through particular...
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NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance
Axon pathfinding is critical for nervous system development, and it is orchestrated by molecular cues that activate receptors on the axonal growth...
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Targeting the transmembrane cytokine co-receptor neuropilin-1 in distal tubules improves renal injury and fibrosis
Neuropilin-1 (NRP1), a co-receptor for various cytokines, including TGF-β, has been identified as a potential therapeutic target for fibrosis....
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Enhanced CD95 and interleukin 18 signalling accompany T cell receptor Vβ21.3+ activation in multi-inflammatory syndrome in children
Multisystem inflammatory syndrome in children is a post-infectious presentation SARS-CoV-2 associated with expansion of the T cell receptor Vβ21.3+...
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The guidance receptor plexin D1 is a mechanosensor in endothelial cells
Shear stress on arteries produced by blood flow is important for vascular development and homeostasis but can also initiate atherosclerosis
1 ....
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Chemokine- and chemokine receptor-based signature predicts immunotherapy response in female colorectal adenocarcinoma patients
The clinical significance and comprehensive characteristics of chemokines and chemokine receptors in female patients with advanced colorectal...
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A receptor–channel trio conducts Ca2+ signalling for pollen tube reception
Precise signalling between pollen tubes and synergid cells in the ovule initiates fertilization in flowering plants
1 . Contact of the pollen tube with...
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RHOA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex
Patients with Tuberous Sclerosis Complex (TSC) show aberrant wiring of neuronal connections formed during development which may contribute to...
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Spatial organization of olfactory receptor gene choice in the complete V1R-related ORA family of zebrafish
The vertebrate sense of smell employs four main receptor families for detection of odors, among them the V1R/ORA family, which is unusually small and...
