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Age- and cell cycle-related expression patterns of transcription factors and cell cycle regulators in Müller glia
Mammalian Müller glia express transcription factors and cell cycle regulators essential for the function of retinal progenitors, indicating the...
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Cell cycle-dependent activation of proneural transcription factor expression and reactive gliosis in rat Müller glia
Retinal Müller glia have a capacity to regenerate neurons in lower vertebrates like zebrafish, but such ability is extremely limited in mammals. In...
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An actin filament branching surveillance system regulates cell cycle progression, cytokinesis and primary ciliogenesis
Dysfunction of cell cycle control and defects of primary ciliogenesis are two features of many cancers. Whether these events are interconnected and...
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Cell cycle gene regulation dynamics revealed by RNA velocity and deep-learning
Despite the fact that the cell cycle is a fundamental process of life, a detailed quantitative understanding of gene regulation dynamics throughout...
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Fibroblast mediated dynamics in diffusively uncoupled myocytes: a simulation study using 2-cell motifs
In healthy hearts myocytes are typically coupled to nearest neighbours through gap junctions. Under pathological conditions such as fibrosis, or in...
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Cell cycle reentry triggers hyperploidization and synaptic dysfunction followed by delayed cell death in differentiated cortical neurons
Cell cycle reentry followed by neuronal hyperploidy and synaptic failure are two early hallmarks of Alzheimer’s disease (AD), however their...
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Cell cycle–dependent localization of the proteasome to chromatin
An integrative understanding of nuclear events including transcription in normal and cancer cells requires comprehensive and quantitative measurement...
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High arrhythmic risk in antero-septal acute myocardial ischemia is explained by increased transmural reentry occurrence
Acute myocardial ischemia is a precursor of sudden arrhythmic death. Variability in its manifestation hampers understanding of arrhythmia mechanisms...
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CPEB1-dependent disruption of the mRNA translation program in oocytes during maternal aging
The molecular causes of deteriorating oocyte quality during aging are poorly defined. Since oocyte developmental competence relies on...
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Effects of different alkylating agents on photoreceptor degeneration and proliferative response of Müller glia
Animal models for retinal degeneration are essential for elucidating its pathogenesis and develo** new therapeutic strategies in humans. N -methyl- N -...
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Specific decreasing of Na+ channel expression on the lateral membrane of cardiomyocytes causes fatal arrhythmias in Brugada syndrome
Reduced cardiac sodium (Na + ) channel current ( I Na ) resulting from the loss-of-function of Na + channel is a major cause of lethal arrhythmias in...
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Phosphatidylserine recognition and Rac1 activation are required for Müller glia proliferation, gliosis and phagocytosis after retinal injury
Müller glia, the principal glial cell type in the retina, have the potential to reenter the cell cycle after retinal injury. In mammals,...
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Death effector domain-containing protein induces vulnerability to cell cycle inhibition in triple-negative breast cancer
Lacking targetable molecular drivers, triple-negative breast cancer (TNBC) is the most clinically challenging subtype of breast cancer. In this...
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Cytoskeletal disarray increases arrhythmogenic vulnerability during sympathetic stimulation in a model of hypertrophic cardiomyopathy
Familial hypertrophic cardiomyopathy (FHC) patients are advised to avoid strenuous exercise due to increased risk of arrhythmias. Mice expressing the...
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New drug discovery of cardiac anti-arrhythmic drugs: insights in animal models
Cardiac rhythm regulated by micro-macroscopic structures of heart. Pacemaker abnormalities or disruptions in electrical conduction, lead to...
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Aging and putative frailty biomarkers are altered by spaceflight
Human space exploration poses inherent risks to astronauts’ health, leading to molecular changes that can significantly impact their well-being....
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Translocation of intracellular CD24 constitutes a triggering event for drug resistance in breast cancer
The capacity of tumor cells to shift dynamically between different states could be responsible for chemoresistance and has been commonly linked to...
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Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo
Differential transcription of identical DNA sequences leads to distinct tissue lineages and then multiple cell types within a lineage, an epigenetic...
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Indispensable role of Galectin-3 in promoting quiescence of hematopoietic stem cells
Hematopoietic stem cells (HSCs) in adult bone marrow (BM) are usually maintained in a state of quiescence. The cellular mechanism coordinating the...
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Structure and mechanism of the alkane-oxidizing enzyme AlkB
Alkanes are the most energy-rich form of carbon and are widely dispersed in the environment. Their transformation by microbes represents a key step...
