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Ironing process optimization for enhanced properties in material extrusion technology using Box–Behnken Design
Material Extrusion (MEX) technology, a prominent process in the field of additive manufacturing (AM), has witnessed significant growth in recent...
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Optimization by Box–Behnken design for environmental contaminants removal using magnetic nanocomposite
In this study, a CoO–Fe 2 O 3 /SiO 2 /TiO 2 (CIST) nanocomposite was synthesized and utilized as an adsorbent to remove methylene blue (MB), malachite green...
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Optimization of microwave-assisted extraction of antioxidant compounds from spring onion leaves using Box–Behnken design
Many studies have explored the extraction of bioactive compounds from different onion solid wastes, such as bulb, skin, and peel. However, onion...
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Condition optimization of eco-friendly RP-HPLC and MCR methods via Box–Behnken design and six sigma approach for detecting antibiotic residues
A precise, Eco-friendly, and highly sensitive RP-HPLC method was employed using quality-by-design principles to concurrently identify cephalexin and...
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Optimization of oil yield of Pelargonium graveolens L'Hér using Box-Behnken design in relation to its antimicrobial activity and in silico study
Pelargonium graveolens L'Hér is an important species of genus Pelargonium with an economic value. The unique rose scent of its oil is used in perfume...
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Optimization of process parameters for trimethoprim and sulfamethoxazole removal by magnetite-chitosan nanoparticles using Box–Behnken design
The contamination of the aquatic environment with antibiotics is among the major and develo** problems worldwide. The present study investigates...
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Application of Box-Behnken design for optimization of phenolics extraction from Leontodon hispidulus in relation to its antioxidant, anti-inflammatory and cytotoxic activities
To the best of our knowledge, there have been no phytochemical studies concerning the wild plant Leontodon hispidulus Boiss. (Asteraceae)....
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Process optimization and modeling of Cd2+ biosorption onto the free and immobilized Turbinaria ornata using Box–Behnken experimental design
The release of effluents containing cadmium ions into aquatic ecosystems is hazardous to humans and marine organisms. In the current investigation,...
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Optimization of the Formulation and Preparation of Andrographolide Microemulsion by Box–Behnken Response Surface Methodology
Andrographis paniculata is a bitter herb used in Asian countries to treat inflammation. Andrographolide (AG) is a diterpenoid compound extracted from...
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Deduction of the operable design space of RP-HPLC technique for the simultaneous estimation of metformin, pioglitazone, and glimepiride
A reversed-phase RP-HPLC method was developed for the simultaneous determination of metformin hydrochloride (MET), pioglitazone (PIO), and...
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Design of experiment-oriented development of solvent-free mixed micellar chromatographic method for concomitant determination of metronidazole and ciprofloxacin hydrochloride
A green, fast and robust solvent-free chromatographic method has been developed for concomitant analysis of ciprofloxacin HCl and metronidazole in...
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Utilizing experimental design and desirability function in optimizing RP-HPLC method for simultaneous determination of some skeletal muscle relaxants and analgesics
An experimental design and response surface methodologies using Plackett–Burman and Box-Behnken designs were applied for selecting and optimizing the...
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Quality by design paradigm for optimization of green stability indicating HPLC method for concomitant determination of fluorescein and benoxinate
A green, robust and fast stability indicating chromatographic method has been developed for concomitant analysis of fluorescein sodium and benoxinate...
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The application of Box-Behnken-Design in the optimization of HPLC separation of fluoroquinolones
Box-Behnken Design is a useful tool for the optimization of the chromatographic analysis. The goal of this study was to select the most significant...
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Agro-waste as a substrate for the production of pullulanase by Penicillium viridicatum under solid-state fermentation
One of the key enzymes utilized in the food industry is pullulanase. But its major drawbacks are its low yield and high production costs. In this...
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Reactive Extraction of Malic Acid using Trioctylamine in 1–Decanol: Equilibrium Studies by Response Surface Methodology Using Box Behnken Optimization Technique
Reactive extraction is a significant technique employed for the removal of organic acids such as carboxylic acid which are usually present in low...
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Optimization, purification, and characterization of xylanase production by a newly isolated Trichoderma harzianum strain by a two-step statistical experimental design strategy
Xylanases are hydrolytic enzymes with a wide range of applications in several industries such as biofuels, paper and pulp, food, and feed. The...
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Bioconversion of waste glycerol into viscosinamide by Pseudomonas fluorescens DR54 and its activity evaluation
Lipopeptides, derived from microorganisms, are promising surface-active compounds known as biosurfactants. However, the high production costs of...
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Preparation, characterization and in vivo pharmacokinetic study of ginsenoside Rb1-PLGA nanoparticles
This study aimed to construct a Ginsenoside Rb1-PLGA nano drug delivery system, optimize its preparation process, characterize and evaluate the...
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Regression analysis on forward modeling of diffuse optical tomography system for carcinoma cell detection
The forward model design was employed in the Diffuse Optical Tomography (DOT) system to determine the optimal photonic flux in soft tissues like the...
