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Precise dating of large flank collapses by single-grain 40Ar/39Ar on pyroclastic deposits from the example of Flores Island (Azores)
Large-scale flank collapses are one of the main hazards associated with the evolution of volcanic islands. Precisely dating such events is critical...
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Cistrome and transcriptome analysis identifies unique androgen receptor (AR) and AR-V7 splice variant chromatin binding and transcriptional activities
The constitutively active androgen receptor (AR) splice variant, AR-V7, plays an important role in resistance to androgen deprivation therapy in...
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Progressive crushing 40Ar/39Ar dating of a gold-bearing quartz vein from the Liaotun Carlin-type gold deposit, Guangxi, southern China
Carlin-type gold deposits are among the largest hydrothermal gold deposits in the world. However, direct dating the metallogenic age of these...
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Cryo-EM structures of adenosine receptor A3AR bound to selective agonists
The adenosine A 3 receptor (A 3 AR), a key member of the G protein-coupled receptor family, is a promising therapeutic target for inflammatory and...
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Timescale of a magmatic-hydrothermal system revealed by 40Ar–39Ar geochronology: the Mio-Pliocene Campiglia Marittima system (Tuscany, Italy)
Petrology and timing of magmatic-hydrothermal systems and the linkage between plutonic and volcanic domains are central topics in geosciences,...
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The PAD-US-AR dataset: Measuring accessible and recreational parks in the contiguous United States
Most spatial epidemiological studies of nature-health relationships use generalized greenspace measures. For instance, coarse-resolution spatial data...
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Reformation of the chondroitin sulfate glycocalyx enables progression of AR-independent prostate cancer
Lineage plasticity of prostate cancer is associated with resistance to androgen receptor (AR) pathway inhibition (ARPI) and supported by a reactive...
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Imaging the state-to-state charge-transfer dynamics between the spin-orbit excited Ar+(2P1/2) ion and N2
Ar + +N 2 → Ar+N 2 + has served as a paradigm for charge-transfer dynamics studies during the last several decades. Despite significant experimental and...
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Noradrenaline depresses facial stimulation-evoked cerebellar MLI-PC synaptic transmission via α2-AR/PKA signaling cascade in vivo in mice
The noradrenergic fibers of the locus coeruleus, together with mossy fibers and climbing fibers, comprise the three types of cerebellar afferents...
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Comparison of circulating tumor cells and AR-V7 as clinical biomarker in metastatic castration-resistant prostate cancer patients
Biomarker in metastatic castration resistant prostate cancer (mCRPC) treatment are rare. We aimed to compare the clinical value of circulating tumor...
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Constrained catecholamines gain β2AR selectivity through allosteric effects on pocket dynamics
G protein-coupled receptors (GPCRs) within the same subfamily often share high homology in their orthosteric pocket and therefore pose challenges to...
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Molecular insights on ar-turmerone as a structural, functional and pharmacophoric analogue of synthetic mosquito repellent DEET by comprehensive computational assessment
Mosquitoes are vectors for a variety of infectious illnesses, and chemical synthetic insecticides have made it possible to control them effectively....
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Integrating Data Directly into Publications with Augmented Reality and Web-Based Technologies – Schol-AR
Scientific research has become highly intertwined with digital information, however scientific publication remains based on the static text and...
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Previously reported CCDC26 risk variant and novel germline variants in GALNT13, AR, and MYO10 associated with familial glioma in Finland
Predisposing factors underlying familial aggregation of non-syndromic gliomas are still to be uncovered. Whole-exome sequencing was performed in four...
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Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer
Endocrine therapies for prostate cancer inhibit the androgen receptor (AR) transcription factor. In most cases, AR activity resumes during therapy...
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G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer
SPOP, an E3 ubiquitin ligase, acts as a prostate-specific tumor suppressor with several key substrates mediating oncogenic function. However, the...
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Enantioselective organocatalytic synthesis of axially chiral aldehyde-containing styrenes via SNAr reaction-guided dynamic kinetic resolution
The precise and efficient construction of axially chiral scaffolds, particularly toward the aryl-alkene atropoisomers with impeccably full...
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Transcriptional network involving ERG and AR orchestrates Distal-less homeobox-1 mediated prostate cancer progression
Distal-less homeobox-1 (DLX1) is a well-established non-invasive biomarker for prostate cancer (PCa) diagnosis, however, its mechanistic...
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Activation of nitrogen species mixed with Ar and H2S plasma for directly N-doped TMD films synthesis
Among the transition metal dichalcogenides (TMD), tungsten disulfide (WS 2 ) and molybdenum disulfide (MoS 2 ) are promising sulfides for replacing noble...
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Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer
Despite advances in the development of highly effective androgen receptor (AR)-directed therapies for the treatment of men with advanced prostate...
