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Engineering the lymph node environment promotes antigen-specific efficacy in type 1 diabetes and islet transplantation
Antigen-specific tolerance is a key goal of experimental immunotherapies for autoimmune disease and allograft rejection. This outcome could...
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Evolution and modulation of antigen-specific T cell responses in melanoma patients
Analyzing antigen-specific T cell responses at scale has been challenging. Here, we analyze three types of T cell receptor (TCR) repertoire data...
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Chimeric antigen receptor T cells targeting FcRH5 provide robust tumour-specific responses in murine xenograft models of multiple myeloma
BCMA-targeting chimeric antigen receptor (CAR) T cell therapy demonstrates impressive clinical response in multiple myeloma (MM). However, some...
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Single-cell profiling of the antigen-specific response to BNT162b2 SARS-CoV-2 RNA vaccine
RNA-based vaccines against SARS-CoV-2 have proven critical to limiting COVID-19 disease severity and spread. Cellular mechanisms driving...
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Microfluidic-based prostate cancer model for investigating the secretion of prostate-specific antigen and microRNAs in vitro
The study of prostate cancer in vitro relies on established cell lines that lack important physiological characteristics, such as proper polarization...
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Validation of novel conditional ligands and large-scale detection of antigen-specific T cells for H-2Dd and H-2Kd
The UV-mediated peptide exchange has enabled the generation of multiple different MHC multimer specificities in parallel, surpassing tedious...
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Antigen-specific Fab profiling achieves molecular-resolution analysis of human autoantibody repertoires in rheumatoid arthritis
The presence of autoantibodies is a defining feature of many autoimmune diseases. The number of unique autoantibody clones is conceivably limited by...
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Adjuvant effects of combination monophosphoryl lipid A and poly I:C on antigen-specific immune responses and protective efficacy of influenza vaccines
Toll-like receptor (TLR) agonists improve vaccine immunogenicity and efficacy, but they are currently unlicensed as adjuvants in influenza vaccines....
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Emergence of an erythroid cell-specific regulatory region in ABO intron 1 attributable to A- or B-antigen expression on erythrocytes in Hominoidea
A- and B-antigens are present on red blood cells (RBCs) as well as other cells and secretions in Hominoidea including humans and apes such as...
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Development of a quantitative NS1 antigen enzyme-linked immunosorbent assay (ELISA) for Zika virus detection using a novel virus-specific mAb
Viruses from the Flaviviridae family, such as Dengue virus (DENV), Yellow fever virus (YFV), and Zika virus (ZIKV) are notorious global public health...
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Novel tumor marker index using carcinoembryonic antigen and carbohydrate antigen 19-9 is a significant prognostic factor for resectable colorectal cancer
We evaluated the usefulness of a newly devised tumor marker index (TMI), namely, the geometric mean of normalized carcinoembryonic antigen (CEA) and...
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Mast cells link immune sensing to antigen-avoidance behaviour
The physiological functions of mast cells remain largely an enigma. In the context of barrier damage, mast cells are integrated in type 2 immunity...
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Epithelial IFNγ signalling and compartmentalized antigen presentation orchestrate gut immunity
All nucleated cells express major histocompatibility complex I and interferon‐γ (IFNγ) receptor
1 , but an epithelial cell-specific function of IFNγ...
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Anti-TACI single and dual-targeting CAR T cells overcome BCMA antigen loss in multiple myeloma
Chimeric Antigen Receptor (CAR) T cells directed to B cell maturation antigen (BCMA) mediate profound responses in patients with multiple myeloma,...
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Site-specific antigen-adjuvant conjugation using cell-free protein synthesis enhances antigen presentation and CD8+ T-cell response
Antigen-adjuvant conjugation is known to enhance antigen-specific T-cell production in vaccine models, but scalable methods are required to generate...
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Mortality reduction and cumulative excess incidence (CEI) in the prostate-specific antigen (PSA) screening era
The extent to which PSA screening is related to prostate cancer mortality reduction in the United States (US) is controversial. US Surveillance,...
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Peptide-HLA-based immunotherapeutics platforms for direct modulation of antigen-specific T cells
Targeted pharmacologic activation of antigen-specific (AgS) T cells may bypass limitations inherent in current T cell-based cancer therapies. We...
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Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds
Protein-based virus-like particles (P-VLPs) are commonly used to spatially organize antigens and enhance humoral immunity through multivalent antigen...
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Antigen recognition reinforces regulatory T cell mediated Leishmania major persistence
Cutaneous Leishmania major infection elicits a rapid T cell response that is insufficient to clear residually infected cells, possibly due to the...
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Antigen presentation plays positive roles in the regenerative response to cardiac injury in zebrafish
In contrast to adult mammals, adult zebrafish can fully regenerate injured cardiac tissue, and this regeneration process requires an adequate and...
