Search
Search Results
-
Functional and morphologic dysfunctions in the airways of rats submitted to an experimental model of obesity-exacerbated asthma
The obesity-exacerbated asthma phenotype is characterized by more severe asthma symptoms and glucocorticoid resistance. The aim of this study was to...
-
Cardiac stress T1-map** response and extracellular volume stability of MOLLI-based T1-map** methods
Stress and rest T1-map** may assess for myocardial ischemia and extracellular volume (ECV). However, the stress T1 response is method-dependent,...
-
Serum metabolomics of hyperbilirubinemia and hyperuricemia in the Tibetan plateau has unique characteristics
Few studies have provided data on the metabolomics characteristics of metabolic diseases such as hyperuricemia and hyperbilirubinemia in the Tibetan...
-
Aminophylline restores glucocorticoid sensitivity in a guinea pig model of sudden sensorineural hearing loss induced by lipopolysaccharide
Glucocorticoids have been used to treat hearing loss and vestibular dysfunction for many years. However, some reports have indicated that a subset of...
-
Association between bronchopulmonary dysplasia and early respiratory morbidity in children with respiratory distress syndrome: a case–control study using nationwide data
Bronchopulmonary dysplasia (BPD) can cause respiratory morbidity beyond the neonatal period. We aimed to analyze the association of BPD on childhood...
-
Aminophylline suppresses stress-induced visceral hypersensitivity and defecation in irritable bowel syndrome
Pharmacological therapy for irritable bowel syndrome (IBS) has not been established. In order to find candidate drugs for IBS with diarrhea (IBS-D),...
-
A2B adenosine receptor inhibition by the dihydropyridine calcium channel blocker nifedipine involves colonic fluid secretion
The adenosine A 2B receptor is a critical protein in intestinal water secretion. In the present study, we screened compound libraries to identify...
-
Trizma as an eco-friendly efficient inhibitor for the acidic corrosion of steel: experimental and computational studies
The inhibition characteristics of Trizma for corrosion of steel in 1 M HCl was investigated using the weight loss, potentiodynamic polarization,...
-
A mixed-methods study on impact of silicosis on tuberculosis treatment outcomes and need for TB-silicosis collaborative activities in India
Globally, silicosis and tuberculosis (TB) have been targeted for elimination by 2030. The study’s objectives were to determine the association of...
-
Morphine versus methylprednisolone or aminophylline for relieving dyspnea in patients with advanced cancer in China: a retrospective study
ContextDyspnea is one of the most common and distressing symptoms that occurs in terminal cancer patients. However, there are no existing treatment...
-
Delayed discharge is associated with higher complement C3 levels and a longer nucleic acid-negative conversion time in patients with COVID-19
To determine factors associated with delayed discharge of hospitalized patients with coronavirus disease (COVID-19). This retrospective cohort study...
-
Prediction of severe adverse events, modes of action and drug treatments for COVID-19’s complications
Following SARS-CoV-2 infection, some COVID-19 patients experience severe host driven adverse events. To treat these complications, their underlying...
-
The clinical value and safety of ECG-gated dipyridamole myocardial perfusion imaging in patients with aortic stenosis
The role of vasodilator myocardial perfusion imaging (MPI) for aortic stenosis (AS) is controversial due to safety and accuracy concerns. In...
-
Examining the impact of inducible ischemia on myocardial fibrosis and exercise capacity in hypertrophic cardiomyopathy
Myocardial ischemia in hypertrophic cardiomyopathy (HCM) is associated with poor outcomes. Vasodilator stress cardiac magnetic resonance (CMR) can...
-
Sweat rate analysis of ivacaftor potentiation of CFTR in non-CF adults
To determine if ivacaftor (Kalydeco) influences non-CF human CFTR function in vivo , we measured CFTR-dependent (C-sweat) and CFTR-independent...
-
Trader as a new optimization algorithm predicts drug-target interactions efficiently
Several machine learning approaches have been proposed for predicting new benefits of the existing drugs. Although these methods have introduced new...
-
Mechanical dyssynchrony and diastolic dysfunction are common in LVH: a pilot correlation study using Doppler echocardiography and CZT gated-SPECT MPI
Hypertrophic cardiomyopathy (HCM) is an often under-diagnosed cause of left ventricular hypertrophy (LVH). It affects 1/500 of the population, is the...
-
Network-Based Approach to Identify Potential Targets and Drugs that Promote Neuroprotection and Neurorepair in Acute Ischemic Stroke
Acute ischemic stroke (AIS) accounts for more than 80% of the approximately 610,000 new stroke cases worldwide every year. Both ischemia and...
-
System biology analysis of long-term effect and mechanism of Bufei Yishen on COPD revealed by system pharmacology and 3-omics profiling
System pharmacology identified 195 potential targets of Bufei Yishen formula (BYF) and BYF was proven to have a short-term therapeutic effect on...
-
A concise drug alerting rule set for Chinese hospitals and its application in computerized physician order entry (CPOE)
BackgroundA minimized and concise drug alerting rule set can be effective in reducing alert fatigue.
ObjectivesThis study aims to develop and...
