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Allele-specific polymerase chain reaction can determine the diplotype of NUDT15 variants in patients with childhood acute lymphoblastic Leukemia
Mercaptopurine intolerance is an adverse effect of mercaptopurine administration in pediatric patients with acute lymphoblastic leukemia (ALL). NUDT15 ...
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A report on the potential of Rac1/pSTAT3 protein levels in T lymphocytes to assess the pharmacodynamic effect of thiopurine therapy in Inflammatory Bowel Disease patients
The thiopurine derivatives azathioprine (AZA), mercaptopurine (MP) and tioguanine (TG) remain standard treatment of inflammatory bowel disease (IBD)....
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Pharmacokinetic–pharmacodynamic modeling of maintenance therapy for childhood acute lymphoblastic leukemia
In the treatment of childhood acute lymphoblastic leukemia (ALL), current protocols combine initial high-dose multiagent chemotherapy with prolonged...
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Loss of Nudt15 thiopurine detoxification increases direct DNA damage in hematopoietic stem cells
Thiopurines, such as 6-mercaptopurine (6-MP), are widely used as cytotoxic agents and immunosuppressants for leukemia and autoimmune or inflammatory...
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Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas
Temozolomide (TMZ) is a standard treatment for glioblastoma (GBM) patients. However, TMZ has moderate therapeutic effects due to chemoresistance of...
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Determination of NUDT15 variants by targeted sequencing can identify compound heterozygosity in pediatric acute lymphoblastic leukemia patients
Mercaptopurine intolerance is an adverse effect of mercaptopurine administration in pediatric acute lymphoblastic leukemia. Recently, NUDT15 variants...
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Interplay between IL6 and CRIM1 in thiopurine intolerance due to hematological toxicity in leukemic patients with wild-type NUDT15 and TPMT
NUDT15 and TPMT variants are strong genetic determinants of thiopurine-induced hematological toxicity. Despite the impact of homozygous CRIM1 on...
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Clinical outcomes of patients with remitting ulcerative colitis after discontinuation of indigo naturalis
Indigo naturalis is an effective treatment for ulcerative colitis. However, long-term use of indigo naturalis causes adverse events, such as...
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Investigation of inherited noncoding genetic variation impacting the pharmacogenomics of childhood acute lymphoblastic leukemia treatment
Defining genetic factors impacting chemotherapy failure can help to better predict response and identify drug resistance mechanisms. However, there...
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Azathioprine promotes intestinal epithelial cell differentiation into Paneth cells and alleviates ileal Crohn’s disease severity
Paneth cells (PCs), a subset of intestinal epithelial cells (IECs) found at the base of small intestinal crypts, play an essential role in...
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Lipid levels and risk of acute pancreatitis using bidirectional Mendelian randomization
Previous studies found lipid levels, especially triglycerides (TG), are associated with acute pancreatitis, but their causalities and bi-directions...
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Longitudinal assessment of sweat-based TNF-alpha in inflammatory bowel disease using a wearable device
Wearable devices can non-invasively monitor patients with chronic diseases. Sweat is an easily accessible biofluid for continuous sampling of...
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Weight loss from diagnosis of Crohn’s disease to one year post-diagnosis results in earlier surgery
Malnutrition might play a key role in the prognosis of patients with Crohn’s disease (CD). The aim of this study was to explore the impact of weight...
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Neuropsychological task outcomes among survivors of childhood acute lymphoblastic leukemia in Malaysia
This study intended to explore the neuropsychological ramifications in childhood acute lymphoblastic leukemia (ALL) survivors in Malaysia and to...
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Identification of purine biosynthesis as an NADH-sensing pathway to mediate energy stress
An enhanced NADH/NAD + ratio, termed reductive stress, is associated with many diseases. However, whether a downstream sensing pathway exists to...
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Cytokine signature in convalescent SARS-CoV-2 patients with inflammatory bowel disease receiving vedolizumab
While differential antibody responses SARS-CoV-2 in patients with inflammatory bowel disease (IBD) receiving infliximab and vedolizumab are...
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Increase in polymorphonuclear myeloid-derived suppressor cells and regulatory T-cells in children with B-cell acute lymphoblastic leukemia
Our study aimed to evaluate the levels of MDSCs and Tregs in pediatric B-cell acute lymphoblastic leukemia (B-ALL), their relation to patients’...
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Genetic landscape of 125 pharmacogenes in Chinese from the Chinese Millionome Database
Inter-individual differences of drug responses could be attributed to genetic variants of pharmacogenes such as cytochrome P450 (CYP), phase 2...
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Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2
The SARS-CoV-2 virus has infected more than 261 million people and has led to more than 5 million deaths in the past year and a half
1 (... 
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Frequency and clinical impact of viraemia in paediatric patients undergoing therapy for cancer
In contrast to transplant recipients, there is a paucity of data regarding frequency and clinical significance of viraemia in children receiving...