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Structure of human drug transporters OATP1B1 and OATP1B3
The organic anion transporting polypeptides OATP1B1 and OATP1B3 are membrane proteins that mediate uptake of drugs into the liver for subsequent...
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The ubiquitin ligase Cullin-1 associates with chromatin and regulates transcription of specific c-MYC target genes
Transcription is regulated through a dynamic interplay of DNA-associated proteins, and the composition of gene-regulatory complexes is subject to...
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Translation factor eIF5a is essential for IFNγ production and cell cycle regulation in primary CD8+ T lymphocytes
Control of mRNA translation adjusts protein production rapidly and facilitates local cellular responses to environmental conditions. Traditionally...
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Diversity of selected toll-like receptor genes in cheetahs (Acinonyx jubatus) and African leopards (Panthera pardus pardus)
The anthropogenic impact on wildlife is ever increasing. With shrinking habitats, wild populations are being pushed to co-exist in proximity to...
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Modulating hierarchical self-assembly in thermoresponsive intrinsically disordered proteins through high-temperature incubation time
The cornerstone of structural biology is the unique relationship between protein sequence and the 3D structure at equilibrium. Although intrinsically...
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Fabrication of fluorescent nanospheres by heating PEGylated tetratyrosine nanofibers
Aromatic polypeptides have recently drawn the interest of the research community for their capability to self-assemble into a variety of functional...
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Low frequency electrical waves in ensembles of proteinoid microspheres
Proteinoids (thermal proteins) are produced by heating amino acids to their melting point and initiation of polymerisation to produce polymeric...
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Chp1 is a dedicated chaperone at the ribosome that safeguards eEF1A biogenesis
Cotranslational protein folding depends on general chaperones that engage highly diverse nascent chains at the ribosomes. Here we discover a...
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Biomarker selection and a prospective metabolite-based machine learning diagnostic for lyme disease
We provide a pipeline for data preprocessing, biomarker selection, and classification of liquid chromatography–mass spectrometry (LCMS) serum samples...
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Structural heterogeneity of the ion and lipid channel TMEM16F
Transmembrane protein 16 F (TMEM16F) is a Ca 2+ -activated homodimer which functions as an ion channel and a phospholipid scramblase. Despite the...
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Production of IgG1-based bispecific antibody without extra cysteine residue via intein-mediated protein trans-splicing
A major class of bispecific antibodies (BsAbs) utilizes heterodimeric Fc to produce the native immunoglobulin G (IgG) structure. Because appropriate...
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Cryo-electron microscopy of IgM-VAR2CSA complex reveals IgM inhibits binding of Plasmodium falciparum to Chondroitin Sulfate A
Placental malaria is caused by Plasmodium falciparum -infected erythrocytes (IEs) adhering to chondroitin sulfate proteoglycans in placenta via...
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The 20S as a stand-alone proteasome in cells can degrade the ubiquitin tag
The proteasome, the primary protease for ubiquitin-dependent proteolysis in eukaryotes, is usually found as a mixture of 30S, 26S, and 20S complexes....
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Acetyl-CoA flux from the cytosol to the ER regulates engagement and quality of the secretory pathway
Nε-lysine acetylation in the ER is an essential component of the quality control machinery. ER acetylation is ensured by a membrane transporter,...
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sUPRa is a dual-color reporter for unbiased quantification of the unfolded protein response with cellular resolution
The unfolded protein response (UPR) maintains proteostasis upon endoplasmic reticulum (ER) stress, and is initiated by a range of physiological and...
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Nascent peptide-induced translation discontinuation in eukaryotes impacts biased amino acid usage in proteomes
Robust translation elongation of any given amino acid sequence is required to shape proteomes. Nevertheless, nascent peptides occasionally...
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Fast and selective organocatalytic ring-opening polymerization by fluorinated alcohol without a cocatalyst
Organocatalysis is an important branch of catalysis for various organic transformations and materials preparation. Polymerizations promoted by...
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Physiological and productivity responses of fenugreek to foliar spraying with molybdenum and cysteine
BackgroundFenugreek ( Trigonella foenum-graecum L.) is one of the oldest cultivated medicinal plants, as well as it is rich with medicinal...
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The lysosomal transporter TAPL has a dual role as peptide translocator and phosphatidylserine floppase
TAPL is a lysosomal ATP-binding cassette transporter that translocates a broad spectrum of polypeptides from the cytoplasm into the lysosomal lumen....
