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Traceless native chemical ligation of lipid-modified peptide surfactants by mixed micelle formation
Biology utilizes multiple strategies, including sequestration in lipid vesicles, to raise the rate and specificity of chemical reactions through...
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Polypeptide formation in clusters of β-alanine amino acids by single ion impact
The formation of peptide bonds by energetic processing of amino acids is an important step towards the formation of biologically relevant molecules....
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Structural insights into N-terminal methionine cleavage by the human mitochondrial methionine aminopeptidase, MetAP1D
Isozymes are enzymes that catalyze identical biological reactions, yet exhibit slight variations in structures and catalytic efficiency, which...
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Design of a methotrexate-controlled chemical dimerization system and its use in bio-electronic devices
Natural evolution produced polypeptides that selectively recognize chemical entities and their polymers, ranging from ions to proteins and nucleic...
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Enhancing the performance of a mutant pyrrolysyl-tRNA synthetase to create a highly versatile eukaryotic cell-free protein synthesis tool
Modification of proteins with a broad range of chemical functionalities enables the investigation of protein structure and activity by manipulating...
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An alternative domain-swapped structure of the Pyrococcus horikoshii PolII mini-intein
Protein splicing is a post-translational process by which an intein catalyzes its own excision from flanking polypeptides, or exteins, concomitant...
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Recognition and reprogramming of E3 ubiquitin ligase surfaces by α-helical peptides
Molecules that induce novel interactions between proteins hold great promise for the study of biological systems and the development of therapeutics,...
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The impact of hydroxyapatite crystal structures and protein interactions on bone's mechanical properties
Hydroxyapatite (HAP) constitutes the primary mineral component of bones, and its crystal structure, along with the surface interaction with proteins,...
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A break in mitochondrial endosymbiosis as a basis for inflammatory diseases
Mitochondria retain bacterial traits due to their endosymbiotic origin, but host cells do not recognize them as foreign because the organelles are...
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DNA binding and RAD51 engagement by the BRCA2 C-terminus orchestrate DNA repair and replication fork preservation
The tumor suppressor BRCA2 participates in DNA double-strand break repair by RAD51-dependent homologous recombination and protects stressed DNA...
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The coding capacity of SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing coronavirus disease 2019 (COVID-19) pandemic
1 . To understand...
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Synthetic intrinsically disordered protein fusion tags that enhance protein solubility
We report the de novo design of small (<20 kDa) and highly soluble synthetic intrinsically disordered proteins (SynIDPs) that confer solubility to a...
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Inducing an LCST in hydrophilic polysaccharides via engineered macromolecular hydrophobicity
Thermoresponsive polysaccharide-based materials with tunable transition temperatures regulating phase-separated microdomains offer substantial...
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The carbonyl-lock mechanism underlying non-aromatic fluorescence in biological matter
Challenging the basis of our chemical intuition, recent experimental evidence reveals the presence of a new type of intrinsic fluorescence in...
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Application of Bld-1-Embedded Elastin-Like Polypeptides in Tumor Targeting
Expression of various molecules on the surface of cancer cells compared to normal cells creates a platform for the generation of various drug...
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De novo emergence of adaptive membrane proteins from thymine-rich genomic sequences
Recent evidence demonstrates that novel protein-coding genes can arise de novo from non-genic loci. This evolutionary innovation is thought to be...
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An in vitro platform for engineering and harnessing modular polyketide synthases
To harness the synthetic power of modular polyketide synthases (PKSs), many aspects of their biochemistry must be elucidated. A robust platform to...
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Polymorphic amyloid nanostructures of hormone peptides involved in glucose homeostasis display reversible amyloid formation
A large group of hormones are stored as amyloid fibrils in acidic secretion vesicles before they are released into the bloodstream and readopt their...
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Cytosolic N-terminal formyl-methionine deformylation derives cancer stem cell features and tumor progression
Eukaryotic cells can synthesize formyl-methionine (fMet)-containing proteins not only in mitochondria but also in the cytosol to some extent. Our...
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Transient disome complex formation in native polysomes during ongoing protein synthesis captured by cryo-EM
Structural studies of translating ribosomes traditionally rely on in vitro assembly and stalling of ribosomes in defined states. To comprehensively...
