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Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells
CRISPR knockout fitness screens in cancer cell lines reveal many genes whose loss of function causes cell death or loss of fitness or, more rarely,...
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Inferring mitochondrial and cytosolic metabolism by coupling isotope tracing and deconvolution
The inability to inspect metabolic activities within distinct subcellular compartments has been a major barrier to our understanding of eukaryotic...
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RNA modification regulator DDC in endometrial cancer affects the tumor microenvironment and patient prognosis
Uterine corpus endometrial carcinoma (UCEC) is infiltrated by immune cells, which are involved in the growth and proliferation of malignant tumors...
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Resveratrol attenuates high glucose-induced inflammation and improves glucose metabolism in HepG2 cells
Diabetes mellitus (DM) is characterized by impaired glucose and insulin metabolism, resulting in chronic hyperglycemia. Hyperglycemia-induced...
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Contribution of serum lipids and cholesterol cellular metabolism in lung cancer development and progression
Neoplasms of the lungs are the leading cause of cancer incidence and mortality worldwide. Although immunotherapy has increased the overall survival...
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A novel tumor-associated neutrophil gene signature for predicting prognosis, tumor immune microenvironment, and therapeutic response in breast cancer
Tumor-associated neutrophils (TANs) can promote tumor progression. This study aimed to investigate the molecular signature that predict the prognosis...
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Chaga mushroom extract suppresses oral cancer cell growth via inhibition of energy metabolism
Oral cancer stands as a prevalent maligancy worldwide; however, its therapeutic potential is limited by undesired effects and complications. As a...
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Tumor phylogeography reveals block-shaped spatial heterogeneity and the mode of evolution in Hepatocellular Carcinoma
Solid tumors are complex ecosystems with heterogeneous 3D structures, but the spatial intra-tumor heterogeneity (sITH) at the macroscopic (i.e.,...
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CD276-dependent efferocytosis by tumor-associated macrophages promotes immune evasion in bladder cancer
Interplay between innate and adaptive immune cells is important for the antitumor immune response. However, the tumor microenvironment may turn...
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m5C regulator-mediated methylation modification phenotypes characterized by distinct tumor microenvironment immune heterogenicity in colorectal cancer
The RNA 5-methylcytosine (m5C) modification has been demonstrated to be an important epigenetic regulator and to impact colorectal cancer (CRC)...
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Probabilistic model checking of cancer metabolism
Cancer cell metabolism is often deregulated as a result of adaption to meeting energy and biosynthesis demands of rapid growth or direct mutation of...
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Dysfunctional adipocytes promote tumor progression through YAP/TAZ-dependent cancer-associated adipocyte transformation
Obesity has emerged as a prominent risk factor for the development of malignant tumors. However, the existing literature on the role of adipocytes in...
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CircRREB1 mediates lipid metabolism related senescent phenotypes in chondrocytes through FASN post-translational modifications
Osteoarthritis is a prevalent age-related disease characterized by dysregulation of extracellular matrix metabolism, lipid metabolism, and...
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Effect of CHST11, a novel biomarker, on the biological functionalities of clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is a common malignant tumor, and the role of carbohydrate sulfotransferase 11 (CHST11) in this cancer remains...
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Characteristics of brain glucose metabolism and metabolic connectivity in noise-induced hearing loss
The purpose of this study was to evaluate the differences in cerebral glucose metabolism and metabolic connectivity between noise-induced hearing...
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Single cell deciphering of progression trajectories of the tumor ecosystem in head and neck cancer
Head and neck squamous cell carcinoma is the sixth most common cancer worldwide and has high heterogeneity and unsatisfactory outcomes. To better...
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Prodrug-conjugated tumor-seeking commensals for targeted cancer therapy
Prodrugs have been explored as an alternative to conventional chemotherapy; however, their target specificity remains limited. The tumor...
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Stroma-associated FSTL3 is a factor of calcium channel-derived tumor fibrosis
Hepatocellular carcinoma (HCC) is the most widespread histological form of primary liver cancer, and it faces great diagnostic and therapeutic...
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Mitofusin 1 silencing decreases the senescent associated secretory phenotype, promotes immune cell recruitment and delays melanoma tumor growth after chemotherapy
Cellular senescence is a therapy endpoint in melanoma, and the senescence-associated secretory phenotype (SASP) can affect tumor growth and...
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Mitochondrial genome transfer drives metabolic reprogramming in adjacent colonic epithelial cells promoting TGFβ1-mediated tumor progression
Although nontumor components play an essential role in colon cancer (CC) progression, the intercellular communication between CC cells and adjacent...
