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Influence of variant-specific mutations, temperature and pH on conformations of a large set of SARS-CoV-2 spike trimer vaccine antigen candidates
SARS-CoV-2 subunit vaccines continue to be the focus of intense clinical development worldwide. Protein antigens in these vaccines most commonly...
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Automated quantification of avian influenza virus antigen in different organs
As immunohistochemistry is valuable for determining tissue and cell tropism of avian influenza viruses (AIV), but time-consuming, an artificial...
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Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma
Despite advancements in cancer immunotherapy, solid tumors remain formidable challenges. In glioma, profound inter- and intra-tumoral heterogeneity...
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Antigen presentation by B cells enables epitope spreading across an MHC barrier
Circumstantial evidence suggests that B cells may instruct T cells to break tolerance. Here, to test this hypothesis, we used a murine model in which...
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Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting
Chimeric antigen receptor (CAR) T cell therapeutic responses are hampered by limited T cell trafficking, persistence, and durable anti-tumor activity...
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TOFIMS mass spectrometry-based immunopeptidomics refines tumor antigen identification
T cell recognition of human leukocyte antigen (HLA)-presented tumor-associated peptides is central for cancer immune surveillance. Mass spectrometry...
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Antigen test swabs are comparable to nasopharyngeal swabs for sequencing of SARS-CoV-2
Viral genomic surveillance has been integral in the global response to the SARS-CoV-2 pandemic. Surveillance efforts rely on the availability of...
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Immunosenescence and vaccine efficacy revealed by immunometabolic analysis of SARS-CoV-2-specific cells in multiple sclerosis patients
Disease-modifying therapies (DMT) administered to patients with multiple sclerosis (MS) can influence immune responses to SARS-CoV-2 and vaccine...
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Catch bond models may explain how force amplifies TCR signaling and antigen discrimination
The TCR integrates forces in its triggering process upon interaction with pMHC. Force elicits TCR catch-slip bonds with strong pMHCs but slip-only...
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Discrete LAT condensates encode antigen information from single pMHC:TCR binding events
LAT assembly into a two-dimensional protein condensate is a prominent feature of antigen discrimination by T cells. Here, we use single-molecule...
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HER2-antigen-specific humoral immune response in breast cancer lymphocytes transplanted in hu-PBL hIL-4 NOG mice
The status of humoral immunity of cancer patients is not clear compared to cellular immunity because the ability of specific antibody production is...
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Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors
The success of cancer immunotherapy depends in part on the strength of antigen recognition by T cells. Here, we characterize the T cell receptor...
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Antigen discrimination by T cells relies on size-constrained microvillar contact
T cells use finger-like protrusions called ‘microvilli’ to interrogate their targets, but why they do so is unknown. To form contacts, T cells must...
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Usefulness of MRI targeted prostate biopsy for detecting clinically significant prostate cancer in men with low prostate-specific antigen levels
We aimed to evaluate the detection rates of prostate cancer (PCa) and clinically significant PCa (csPCa) using magnetic resonance imaging-targeted...
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The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing
Dendritic cells play a key role in processing and presenting antigens to naïve T cells to prime adaptive immunity. Circadian rhythms are known to...
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Public health-focused use of COVID-19 rapid antigen and PCR tests
During the Covid-19 pandemic, accurate PCR tests were augmented by the cheap, rapid, and logistically convenient, yet less sensitive antigen tests....
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A prostate-specific membrane antigen (PSMA)-targeted prodrug with a favorable in vivo toxicity profile
Prostate-specific membrane antigen (PSMA) is a promising target for the treatment of advanced prostate cancer (PC) and various solid tumors. Although...
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Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma
Allogeneic natural killer (NK) cell adoptive transfer is a promising treatment for several cancers but is less effective for the treatment of...
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Dengue NS1 antigen kit shows high sensitivity for detection of recombinant dengue virus-2 NS1 antigen spiked with Aedes aegypti mosquitoes
Dengue, caused by the dengue virus (DENV) is a significant vector-borne disease. In absence of a specific treatment and vaccine, dengue is becoming a...
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Impact of antigen test target failure and testing strategies on the transmission of SARS-CoV-2 variants
Population testing remains central to COVID-19 control and surveillance, with countries increasingly using antigen tests rather than molecular tests....
