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Older adults and individuals with Parkinson’s disease control posture along suborthogonal directions that deviate from the traditional anteroposterior and mediolateral directions
A rich and complex temporal structure of variability in postural sway characterizes healthy and adaptable postural control. However,...
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Autonomic function and motor subtypes in Parkinson’s disease: a multicentre cross-sectional study
Autonomic symptoms (AS) are critical in Parkinson’s disease (PD). We aimed to determine the relative significance of clinical factors allowing...
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Patient-specific models link neurotransmitter receptor mechanisms with motor and visuospatial axes of Parkinson’s disease
Parkinson’s disease involves multiple neurotransmitter systems beyond the classical dopaminergic circuit, but their influence on structural and...
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Prediction of dyskinesia in Parkinson’s disease patients using machine learning algorithms
Dyskinesias are non preventable abnormal involuntary movements that represent the main challenge of the long term treatment of Parkinson’s disease...
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Cervical percutaneous interferential current stimulation improves citric acid cough tests in patients with Parkinson’s disease on medication
Aspiration pneumonia is the leading cause of death in patients with Parkinson’s disease. The incidence of silent aspiration is high in such patients...
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Adaptive neighborhood rough set model for hybrid data processing: a case study on Parkinson’s disease behavioral analysis
Extracting knowledge from hybrid data, comprising both categorical and numerical data, poses significant challenges due to the inherent difficulty in...
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Chronic intracranial recordings in the globus pallidus reveal circadian rhythms in Parkinson’s disease
Circadian rhythms have been shown in the subthalamic nucleus (STN) in Parkinson’s disease (PD), but only a few studies have focused on the globus...
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Numerosity estimation of virtual humans as a digital-robotic marker for hallucinations in Parkinson’s disease
Hallucinations are frequent non-motor symptoms in Parkinson’s disease (PD) associated with dementia and higher mortality. Despite their high clinical...
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Pathological pallidal beta activity in Parkinson’s disease is sustained during sleep and associated with sleep disturbance
Parkinson’s disease (PD) is associated with excessive beta activity in the basal ganglia. Brain sensing implants aim to leverage this biomarker for...
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A reversible state of hypometabolism in a human cellular model of sporadic Parkinson’s disease
Sporadic Parkinson’s Disease (sPD) is a progressive neurodegenerative disorder caused by multiple genetic and environmental factors. Mitochondrial...
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An optimized Nurr1 agonist provides disease-modifying effects in Parkinson’s disease models
The nuclear receptor, Nurr1, is critical for both the development and maintenance of midbrain dopamine neurons, representing a promising molecular...
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The hexosamine biosynthetic pathway rescues lysosomal dysfunction in Parkinson’s disease patient iPSC derived midbrain neurons
Disrupted glucose metabolism and protein misfolding are key characteristics of age-related neurodegenerative disorders including Parkinson’s disease,...
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Neural signatures of indirect pathway activity during subthalamic stimulation in Parkinson’s disease
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) produces an electrophysiological signature called evoked resonant neural activity...
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Gut microbiota of Parkinson’s disease in an appendectomy cohort: a preliminary study
In patients with Parkinson’s disease (PD), α-synuclein pathology is thought to spread to the brain via the dorsal motor nucleus of the vagus nerve....
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Prevalence and characteristics of dry eye disease in Parkinson’s disease: a systematic review and meta-analysis
We investigated and characterized the prevalence of dry eye disease (DED) in Parkinson’s disease (PD). PubMed and EMBASE databases were searched for...
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Eye movement function captured via an electronic tablet informs on cognition and disease severity in Parkinson’s disease
Studying the oculomotor system provides a unique window to assess brain health and function in various clinical populations. Although the use of...
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Prediction of cognitive decline in Parkinson’s disease (PD) patients with electroencephalography (EEG) connectivity characterized by time-between-phase-crossing (TBPC)
The aim of the study is to identify the dynamic change pattern of EEG to predict cognitive decline in patients with Parkinson’s disease. Here we...
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Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease
Soluble α-synuclein aggregates varying in size, structure, and morphology have been closely linked to neuronal death in Parkinson’s disease. However,...
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High risk of develo** dementia in Parkinson’s disease: a Swedish registry-based study
Dementia have substantial negative impact on the affected individual, their care partners and society. Persons living with Parkinson’s disease (PwP)...
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Multi-omics integration of scRNA-seq time series data predicts new intervention points for Parkinson’s disease
Parkinson’s disease (PD) is a complex neurodegenerative disorder without a cure. The onset of PD symptoms corresponds to 50% loss of midbrain...
