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Single-cell RNA sequencing identifies shared differentiation paths of mouse thymic innate T cells
Invariant natural killer T (iNKT), mucosal-associated invariant T (MAIT), and γδ T cells are innate T cells that acquire memory phenotype in the...
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Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells
Most T lymphocytes leave the thymus as naïve cells with limited functionality. However, unique populations of innate-like T cells differentiate into...
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Immunoprofiling reveals cell subsets associated with the trajectory of cytomegalovirus reactivation post stem cell transplantation
Human cytomegalovirus reactivation is a major opportunistic infection after allogeneic haematopoietic stem cell transplantation and has a complex...
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A multilayered immune system through the lens of unconventional T cells
The unconventional T cell compartment encompasses a variety of cell subsets that straddle the line between innate and adaptive immunity, often reside...
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Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection
Mucosa-associated invariant T (MAIT) cell loss in chronic HIV-1 infection is a significant insult to antimicrobial immune defenses. Here we...
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Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells
MR1-restricted T (MR1T) cells recognize microbial small molecule metabolites presented on the MHC Class I-like molecule MR1 and have been implicated...
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CAR+ and CAR− T cells share a differentiation trajectory into an NK-like subset after CD19 CAR T cell infusion in patients with B cell malignancies
Chimeric antigen receptor (CAR) T cell therapy is effective in treating B cell malignancies, but factors influencing the persistence of functional CAR
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NBEAL2 deficiency in humans leads to low CTLA-4 expression in activated conventional T cells
Loss of NBEAL2 function leads to grey platelet syndrome (GPS), a bleeding disorder characterized by macro-thrombocytopenia and α-granule-deficient...
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A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice
Interactions with commensal microbes shape host immunity on multiple levels and play a pivotal role in human health and disease. Tissue-dwelling,...
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Artificially induced MAIT cells inhibit M. bovis BCG but not M. tuberculosis during in vivo pulmonary infection
There is significant interest in targeting MAIT cells with immunostimulatory agents to enhance immune responses. Mycobacterium tuberculosis ( M. tb .)...
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Rab6 regulates recycling and retrograde trafficking of MR1 molecules
Mucosal-associated invariant T (MAIT) cells are an innate-like T cell subset important in the early response to bacterial and viral lung pathogens....
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Single-cell RNA sequencing of immune cells in patients with acute gout
Cell subpopulations in the blood and joint fluid of patients with gout are poorly understood. Single-cell RNA sequencing and bioinformatic tools were...
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Pre-T cell receptor self-MHC sampling restricts thymocyte dedifferentiation
Programming T cells to distinguish self from non-self is a vital, multi-step process that occurs in the thymus
1 –4 . Signalling through the pre-T cell...
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MarsGT: Multi-omics analysis for rare population inference using single-cell graph transformer
Rare cell populations are key in neoplastic progression and therapeutic response, offering potential intervention targets. However, their...
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Single cell T cell landscape and T cell receptor repertoire profiling of AML in context of PD-1 blockade therapy
In contrast to the curative effect of allogenic stem cell transplantation in acute myeloid leukemia via T cell activity, only modest responses are...
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Secondary bone marrow graft loss after third-party virus-specific T cell infusion: Case report of a rare complication
Virus-specific T cells (VST) from partially-HLA matched donors have been effective for treatment of refractory viral infections in immunocompromised...
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Clonal dynamics of alloreactive T cells in kidney allograft rejection after anti-PD-1 therapy
Kidney transplant recipients are at particular risk for develo** tumors, many of which are now routinely treated with immune checkpoint inhibitors...
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Classical MHC expression by DP thymocytes impairs the selection of non-classical MHC restricted innate-like T cells
Conventional T cells are selected by peptide-MHC expressed by cortical epithelial cells in the thymus, and not by cortical thymocytes themselves that...
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Single-cell gene fusion detection by scFusion
Gene fusions can play important roles in tumor initiation and progression. While fusion detection so far has been from bulk samples, full-length...
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Enhanced CD95 and interleukin 18 signalling accompany T cell receptor Vβ21.3+ activation in multi-inflammatory syndrome in children
Multisystem inflammatory syndrome in children is a post-infectious presentation SARS-CoV-2 associated with expansion of the T cell receptor Vβ21.3+...
