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SPRING licenses S1P-mediated cleavage of SREBP2 by displacing an inhibitory pro-domain
Site-one protease (S1P) conducts the first of two cleavage events in the Golgi to activate Sterol regulatory element binding proteins (SREBPs) and...
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MAGinator enables accurate profiling of de novo MAGs with strain-level phylogenies
Metagenomic sequencing has provided great advantages in the characterisation of microbiomes, but currently available analysis tools lack the ability...
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Proteomic profiling of regenerated urinary bladder tissue in a non-human primate augmentation model
Urinary bladder dysfunction can be caused by environmental, genetic, and developmental insults. Depending upon insult severity, the bladder may lose...
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Evolution and subfunctionalization of CIPK6 homologous genes in regulating cotton drought resistance
The occurrence of whole-genome duplication or polyploidy may promote plant adaptability to harsh environments. Here, we clarify the evolutionary...
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Ionic liquid based surfactant-free microemulsion as a new protocol for preparation of visible light active poly(methyl methacrylate)/TiO2 nanocomposite
The practical application of sensitized TiO 2 nanocomposites is very satisfying due to their high photon utilization in visible light, simple recovery...
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Heterogeneity in lung macrophage control of Mycobacterium tuberculosis is modulated by T cells
Following Mycobacterium tuberculosis infection, alveolar macrophages are initially infected but ineffectively restrict bacterial replication. The...
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Lithium-ion battery components are at the nexus of sustainable energy and environmental release of per- and polyfluoroalkyl substances
Lithium-ion batteries (LiBs) are used globally as a key component of clean and sustainable energy infrastructure, and emerging LiB technologies have...
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B-cell hub genes play a cardiovascular pathogenic role of in childhood obesity and Kawasaki disease as revealed by transcriptomics-based analyses
The study aims to explore the central genes that Kawasaki disease (KD) and Obesity (OB) may jointly contribute to coronary artery disease....
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High-resolution elevation models of Larsen B glaciers extracted from 1960s imagery
Accelerated warming since the 1950s has caused dramatic change to ice shelves and outlet glaciers on the Antarctic Peninsula. Long observational...
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Different clinicopathological features between young and older patients with pulmonary adenocarcinoma and ground-glass opacity
After the recommendation of computed tomography as a routine procedure for lung cancer screening, an increasing number of young adults have been...
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Perturbation of METTL1-mediated tRNA N7- methylguanosine modification induces senescence and aging
Cellular senescence is characterized by a decrease in protein synthesis, although the underlying processes are mostly unclear. Chemical modifications...
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Genetically encoded Nδ-vinyl histidine for the evolution of enzyme catalytic center
Genetic code expansion has emerged as a powerful tool for precisely introducing unnatural chemical structures into proteins to improve their...
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Genome wide identification of novel DNA methylation driven prognostic markers in colorectal cancer
Colorectal cancer (CRC) stands as a major contributor to cancer-related fatalities within China. There is an urgent need to identify accurate...
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Multivariate analysis of the summer herbaceous vegetation and environmental factors of the sub-tropical region
Understanding the distribution of the plant species of an unexplored area is the utmost need of the present-day. In order to collect vegetation data,...
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Tracing sources of inorganic suspended particulate matter in the Great Barrier Reef lagoon, Australia
Water clarity on the inshore Great Barrier Reef (GBR) is greatly influenced by terrestrial runoff of suspended particulate matter (SPM). Catchment...
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A dynamic attribute reduction algorithm based on relative neighborhood discernibility degree
This paper addresses the current existence of attribute reduction algorithms for incomplete hybrid decision-making systems, including low attribute...
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Flexible tungsten disulfide superstructure engineering for efficient alkaline hydrogen evolution in anion exchange membrane water electrolysers
Anion exchange membrane (AEM) water electrolysis employing non-precious metal electrocatalysts is a promising strategy for achieving sustainable...
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Multi-objective energy management in a renewable and EV-integrated microgrid using an iterative map-based self-adaptive crystal structure algorithm
The use of plug-in hybrid electric vehicles (PHEVs) provides a way to address energy and environmental issues. Integrating a large number of PHEVs...
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Coherent spin qubit shuttling through germanium quantum dots
Quantum links can interconnect qubit registers and are therefore essential in networked quantum computing. Semiconductor quantum dot qubits have seen...
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Dysregulated gene subnetworks in breast invasive carcinoma reveal novel tumor suppressor genes
Breast invasive carcinoma (BRCA) is the most malignant and leading cause of death in women. Global efforts are ongoing for improvement in early...
