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Simulation Modeling of Glutamate Cysteine Ligase Activity
AbstractGlutathione (γ-glutamyl-cysteinyl-glycine) is one of the main intracellular antioxidants that play an important role in cellular metabolism....
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Accuracy in readout of glutamate concentrations by neuronal cells
AbstractGlutamate and glycine are important neurotransmitters in the brain. An action potential propagating in the terminal of a presynaptic neuron...
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Functional Magnetic Resonance Spectroscopy Study of Total Glutamate and Glutamine in the Human Visual Cortex Activated by a Short Stimulus
Abstract —Glutamate+glutamine (Glx) dynamics with 2s time resolution in the human occipital cortex in response to short visual stimulation was studied...
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Secondary Metabolites and Amino Acids in the Neocortex of the Long-Tailed Ground Squirrel Urocitellus undulatus at Different Stages of Hibernation
This study continues our previous research aimed at investigating changes in the pools of amino acids in the myocardium of the ground squirrel during...
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Meconic Acid Is a Possible Neuroprotector: Justification Based on in vitro Experiments and Its Physicochemical Properties
AbstractMeconic, comenic, chelidonic, and kojic acids are the main representatives of gamma-pyronic acids. It was found that comenic acid has a...
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Monitoring Metabolism with NMR
The self-assembly of living systems is first and foremost based on structure, but function is also essential for life. At the cellular level, the...
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Terahertz Photons Enhance the Transmission of Calcium Ions Through NMDA Receptor
N-Methyl-D-aspartate (NMDA) receptors, also glutamate-gated calcium ion channels, play essential roles in synaptic transmission and plasticity and...
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Analysis of the Effect of Exogenous Nicotinamide on Bioenergetic Processes in the Brain During Acute Hypoxia
AbstractPotential mechanisms for the realization of the neuroprotective action of nicotinamide during acute lethal short-term hypoxia were evaluated...
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Chemical shift assignments of calmodulin bound to a cytosolic domain of GluN2A (residues 1004–1024) from the NMDA receptor
N-methyl-D-aspartate receptors (NMDARs) consist of glycine-binding GluN1 and glutamate-binding GluN2 subunits that form tetrameric ion channels....
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X-ray Tomography Study of 3D Hydrogel Structure
The optic nerve exhibits a hierarchical aligned structure with functional performances. Tissue engineering has emerged as a potential technique to...
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A Model of Glutamate Neurotoxicity and Mechanisms of the Development of the Typical Pathological Process
AbstractA glutamate model of stroke was analyzed from the standpoint of the development of a typical pathological process that is thought to occur...
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Chemical shift assignments of calmodulin bound to the GluN1 C0 domain (residues 841–865) of the NMDA receptor
Neuroplasticity and synaptic transmission in the brain are regulated by N-methyl-D-aspartate receptors (NMDARs) that consist of hetero-tetrameric...
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Chemical shift assignments of the N-terminal domain of PSD95 (PSD95-NT)
Postsynaptic density protein-95 (PSD95) contributes to the postsynaptic architecture of neuronal synapses and plays an important role in controlling...
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Monosodium glutamate for accidental, retrospective, and medical dosimetry using electron spin resonance
The risk of a radiation episode has increased in the last years due to several reasons. In case of a nuclear incident, as with the use of an...
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Effects of Terahertz Wave Irradiation on ATP Synthase
Energy metabolism is a necessary process to maintain life processes. Observing the cellular energy metabolism process reveals the pivotal roles of...
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The Molecular Mechanism of Neural Signal Transduction Based on Terahertz Irradiation
With the development of terahertz sources and detection devices, an increasing number of terahertz irradiation biological effects have been...
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Disturbances of Cerebral Metabolism of Aspartate, Glutamate, and N-Acetylaspartate after Traumatic Brain Injury According to 1H Magnetic Resonance Spectroscopy
AbstractCerebral concentrations of N-acetylaspartate, aspartate, and glutamate were determined for the first time simultaneously in patients with...
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Site-specific resolution of anionic residues in proteins using solid-state NMR spectroscopy
NMR spectroscopy is commonly used to infer site-specific acid dissociation constants (p K a ) since the chemical shift is sensitive to the protonation...
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Bioinformatics Analysis of Terahertz Photons on Breast Cancer Cells
Although it has been shown that terahertz (THz) waves can lead to epigenetic changes in cancer cells, little is known about the therapeutic effects...